Consumption of a high-salt diet by ewes during pregnancy alters nephrogenesis in 5-month-old offspring

Maternal nutrition during pregnancy can affect kidney development in the foetus, which may lead to adverse consequences in the mature kidney. It was expected that high-salt intake by pregnant ewes would lead to a reduction in foetal glomerular number but that the ovine kidney would adapt to maintain homoeostasis, in part by increasing the size of each glomerulus. Merino ewes that were fed either a control (1.5% NaCl) or high-salt (10.5% NaCl) diet during pregnancy, as well as their 5-month-old offspring, were subjected to a dietary salt challenge, and glomerular number and size and sodium excretion were measured. The high-salt offspring had 20% fewer glomeruli compared with the control offspring ( P,0.001), but they also had larger glomerular radii compared with the control offspring ( P,0.001). Consequently, the cross-sectional area of glomeruli was 18% larger in the high-salt offspring than in the control offspring ( P,0.05). There was no difference in the daily urinary sodium excretion between the two offspring groups ( P.0.05), although the high-salt offspring produced urine with a higher concentration of sodium. Our results demonstrated that maternal high-salt intake during pregnancy affected foetal nephrogenesis, altering glomerular number at birth. However, the ability to concentrate and excrete salt was not compromised, which indicates that the kidney was able to adapt to the reduction in the number of glomeruli

Scale-adaptive simulation (SAS) of dynamic stall on a wind turbine

Scale-adaptive simulation (SAS) approach is employed to investigate the complex dynamic stall phenomena occurring on a wind turbine blade. The results are com-pared with the more popular less computationally-expensive unsteady Reynolds-averaged Navier-Stokes (URANS) approach where the latter is validated using three sets of experimental data. The comparison reveals that the two approaches have similar predictions of the instant of the formation/bursting/shedding of the laminar separation bubble (LSB) and dynamic stall vortex (DSV), the size of the LSB and aerodynamic loads during the upstroke. This is while the two approach-es exhibit dissimilar predictions of the trailing-edge vortex characteristics, its in-teraction with the DSV, number of secondary vortices and aerodynamic loads during the downstroke