Effects of exercise upon the incidence and development of cancer

Cancer is a disease responsible for millions of deaths annually around the world. Several studies with animals and human beings suggest that the practice of exercises is related to a reduction in the incidence of this disease. The objective of this work was to review the literature about the effects of exercise of different intensities upon the incidence and development of cancer. The review of literature demonstrated that in spite of considerable evidences about a possible benefit effect of physical exercise (mainly moderate) in relationship to cancer, like the reduction of its evidence, there are yet, many controversial features about this subject. This problem occurs mainly due to the fact that the major part of studies are of a epidemiological type. Finally, we concluded that more precise knowledge will only be obtained with the conduction of studies that control factors like intensity and duration of exerciseO câncer é uma doença responsável por milhões de mortes anualmente no mundo. Diversos estudos realizados em animais e em seres humanos sugerem que a prática de exercícios pode estar relacionada a redução da incidência dessa doença. O objetivo desse trabalho foi revisar a literatura sobre os efeitos do exercício de diferentes intensidades sobre o surgimento e o desenvolvimento do câncer. A revisão cuidadosa da literatura demonstrou que embora existam evidências consideráveis sobre um possível efeito benéfico do exercício físico (principalmente moderado) sobre o câncer, como a redução de sua incidência, ainda há inúmeras controvérsias quanto ao assunto. Tais controvérsias ocorrem principalmente devido ao fato de que a maior parte dos estudos sobre o assunto ser do tipo epidemiológico. Finalmente, concluiu-se que conhecimentos mais precisos só serão obtidos a partir da realização de estudos que apresentem controle rigoroso de fatores como a intensidade e a duração do exercíci

Avaliação da dieta, crescimento, maturação sexual e treinamento de crianças e adolescentes atletas de ginástica rítmica

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Endurance exercise bout does not interfere in strength performance of upper limbs

OBJETIVO: O presente estudo avaliou o efeito do exercício de endurance (corrida) sobre o subseqüente desempenho de força de músculos dos membros superiores e do tronco. METODOLOGIA: A amostra foi composta por 13 universitárias, saudáveis e fisicamente ativas. A primeira fase do experimento consistiu na realização de um teste de corrida, simulando uma sessão de treino, com duração de 45 minutos a 70% da FC MAX. Imediatamente após a corrida, foram aplicados testes de força (dinamometria - preensão palmar, teste de 1-RM e teste de repetições máximas a 70%-1RM no supino). A glicemia foi mensurada no início do experimento e imediatamente antes dos testes de força. RESULTADOS: Não foi observada diferença significativa no desempenho dos testes de força após o treino de corrida (dinamometria, 1-RM e REPMAX - sem a prévia execução do treino de corrida - 29,9 ± 3,8 kgf; 34,4 ± 3,1 kg; 1ºset: 12,5 ± 3,3 reps e 2ºset: 11,7 ± 2,7 reps vs. com a prévia execução do treino de corrida - 29,2 ± 3,1 kgf; 33,9 ± 2,5 kg; 1ºset: 13,2 ± 2,1 reps e 2ºset: 12,2 ± 2,8 reps). Com relação à glicemia, não foi detectada alteração significativa durante o experimento. CONCLUSÃO: A execução do treino de corrida não afetou o subseqüente desempenho de força dos membros superiores e do tronco. Esse dado sugere que a interferência, freqüentemente, observada no exercício concorrente, é dependente do grupo muscular treinado. Possivelmente, o efeito adverso induzido pelo treino concorrente, realizado, exclusivamente, com membros inferiores, é decorrente da fadiga residual instalada nos músculos recrutados na atividade anterior. É importante ressaltar que a atividade de endurance não promoveu alteração na concentração plasmática de glicose. A manutenção da glicemia associada à ausência de interferência sobre o desempenho dos testes de força reforça, mais ainda, a hipótese de que o efeito adverso do treinamento concorrente é, provavelmente, causado por alterações periféricas músculo-específicas.AIM: the present study evaluated the effect of endurance exercise (running) on the subsequent strength performance of muscles of upper limbs and trunk. METHODOLOGY: Thirteen healthy female, university students, physically active were selected to compose the sample. The first phase of the experiment the subjects were submitted to an endurance exercise bout (treadmill), simulating a training session, with duration of 45 minutes at 70% of the HRmax. Immediately after the endurance exercise bout, the subjects performed strength tests (Dynamometry test - handgrip, 1RM test and maximal repetitions test at 70%-1RM in the bench press). Glycemia was measured in the beginning of the experiment and immediately before the strength tests. RESULTS: No significant difference was observed in the strength tests performance after the endurance exercise bout (Dynamometry, 1-RM and REPMAX - with no previous endurance exercise - 29.9 ± 3.8 kgf; 34.4 ± 3.1 kg; 1st set 12.5 ± 3.3 reps and 2nd set 11.7 ± 2.7 reps vs. with previous endurance exercise - 29.2 ± 3.1 kgf; 33.9 ± 2.5 kg; 1st set 13.2 ± 2.1 reps and 2nd set 12.2 ± 2.8 reps). Regarding glycemia, no significant alteration was observed during the experiment. CONCLUSION: the endurance exercise bout did not affect the subsequent strength performance of the upper limbs and trunk. This data suggests that the common interference observed in the concurrent training is dependent on which muscular group has been recruited. Possibly, the adverse effect induced by the concurrent training, exclusively performed with lower extremities, is due to the residual fatigue installed in the muscles recruited in the previous activity. It is important to highlight that endurance exercise did not promote alteration in the glucose plasma concentration. The glycemia maintenance associated with the lack of interference on the performance of the strength tests reinforces even more the hypothesis that the adverse effect of the concurrent training is probably caused by muscle-specific peripheral alterations

Protein supplementation does not increase nitric oxide plasmatic concentration in healthy men

Suplementos nutricionais, supostamente, capazes de potencializar a produção endógena de óxido nítrico (NO) têm experimentado crescente popularidade entre os indivíduos fisicamente ativos. Diante da carência de informações sobre o assunto, o objetivo do presente estudo foi avaliar o efeito de um suplemento comercial à base de proteínas e aminoácidos sobre a produção endógena de NO. MÉTODOS: A amostra foi constituída de 12 homens sedentários, mas sem fatores de risco para doenças cardiovasculares. O protocolo de suplementação foi conduzido conforme o arranjo experimental duplo-cego cruzado. Os participantes receberam, aleatoriamente, placebo (PLA) ou suplemento proteico (SP), em dois momentos diferentes, separados por uma semana. Com o intuito de determinar a concentração plasmática de NO, amostras de sangue foram coletadas antes (24h e imediatamente antes) e depois (30 e 60 minutos) do consumo da substância PLA ou do SP. RESULTADOS: Não foi observada alteração na concentração plasmática de NO após a ingestão do SP em comparação com o PLA (pós-suplementação 30min - PLA: 19,3 ± 4,7µmol.L- 1 vs. SP: 18,9 ± 4,4µmol.L-1 e pós-suplementação 60min - PLA: 21,3 ± 6,5µmol.L-1 vs. SP: 20,3 ± 4,9µmol.L-1). Também não foi verificada alteração da pressão arterial. CONCLUSÃO: O suplemento nutricional à base de proteínas e aminoácidos, testado no presente estudo, não potencializou a produção endógena de NO.Nutritional supplements, theoretically able to increase endogenous nitric oxide (NO) production have experienced great popularity among physically active individuals. AIM: scientific evidence available regarding this issue is scarce. Therefore, the purpose of this study was to evaluate the effect of a dietary supplement commercialized as a nitric oxide booster. MATERIALS AND METHODS: twelve sedentary men with no risk factors for cardiovascular diseases were supplemented with placebo or protein in two different occasions. The present study was conducted in a cross double-blind design. In order to assess plasmatic NO concentration, blood samples were obtained before (24hs and immediately before) and after (30 and 60 minutes) consumption of placebo (PLA) or protein supplement (SP). RESULTS: there was no difference in plasmatic nitric oxide concentration between both trails (Post-supplementation 30 min - PLA: 19.3±4.7 µmol.L-1 vs. SP: 18.9±4.4 µmol.L-1 and Post-supplementation 60 min - PLA: 21.3±6.5 µmol.L-1 vs. SP: 20.3±4.9 µmol.L-1). In addition, no difference was detected for arterial blood pressure. CONCLUSION: the dietary supplement analyzed in the present study failed to increase nitric oxide endogenous production

Salivary IL-21 and IgA responses to a competitive match in elite basketball players

Athletes engaged in strenuous training might experience transient immune suppression that could lead to greater incidence of upper respiratory tract infections (URTI). Since interleukin 21 (IL-21) stimulates immunoglobulin A (IgA) secreting cells and a low level of this immunoglobulin is associated with increased incidence of URTI, the aim of the present study was to investigate the effect of a basketball match on salivary cortisol (sC), salivary IL-21 (sIL-21) and salivary IgA (sIgA) levels. Twenty male basketball players participated in an official game in two teams (10 players in each team). The saliva samples were collected before the warm-up and approximately 10-15 min after the end of the match and were analysed by ELISA methods. sC concentration increased significantly after the match while sIL-21 level was reduced (p < 0.05). In opposition to the study’s hypothesis, sIgA level did not change in response to the match. The present findings suggest that a basketball match is sufficiently stressful to elevate sC concentration and attenuates the sIL-21 output without compromising the sIgA level. It is reasonable to speculate that the stability of sIgA acute responses to the match, despite the decrement in sIL-21, indicates that other mechanisms rather than IL-21 stimulating B cell proliferation/differentiation might modulate IgA concentration and secretion rate.FAPESP 2008/10404-

Resistance Training in Spontaneously Hypertensive Rats with Severe Hypertension

Background: Resistance training (RT) has been recommended as a non-pharmacological treatment for moderate hypertension. In spite of the important role of exercise intensity on training prescription, there is still no data regarding the effects of RT intensity on severe hypertension (SH). Objective: This study examined the effects of two RT protocols (vertical ladder climbing), performed at different overloads of maximal weight carried (MWC), on blood pressure (BP) and muscle strength of spontaneously hypertensive rats (SHR) with SH. Methods: Fifteen male SHR [206 +/- 10 mmHg of systolic BP (SBP)] and five Wistar Kyoto rats (WKY; 119 +/- 10 mmHg of SBP) were divided into 4 groups: sedentary (SED-WKY) and SHR (SED-SHR); RT1-SHR training relative to body weight (similar to 40% of MWC); and RT2-SHR training relative to MWC test (similar to 70% of MWC). Systolic BP and heart rate (HR) were measured weekly using the tail-cuff method. The progression of muscle strength was determined once every fifteen days. The RT consisted of 3 weekly sessions on non-consecutive days for 12-weeks. Results: Both RT protocols prevented the increase in SBP (delta -5 and -7 mmHg, respectively; p > 0.05), whereas SBP of the SED-SHR group increased by 19 mmHg (p 0.05). Conclusions: Our data indicated that both RT protocols were effective in preventing chronic elevation of SBP in SH. Additionally, a higher RT overload induced a greater increase in muscle strength.Fundamentos: O treinamento de força (TF) tem sido recomendado como tratamento não farmacológico para hipertensão arterial moderada. Apesar do papel importante que a intensidade do exercício desempenha sobre a prescrição do treinamento, ainda não há nenhum dado avaliando os efeitos da intensidade do TF sobre a hipertensão arterial grave (HAG). Objetivo: Este estudo analisou os efeitos de dois protocolos do TF(subida em escada vertical), realizados com diferentes sobrecargas do peso máximo carregado (PMC), sobre a pressão arterial (PA) e a força muscular de ratos espontaneamente hipertensos (SHR) com HAG. Métodos: Quinze SHR machos (206 ± 10 mmHg de PA sistólica (PAS)) e cinco ratos Wistar Kyoto (WKY; 119 ± 10 mmHg de PAS) foram divididos em 4grupos:sedentários: (SED-WKY) e SHR (SED-SHR); treinados: TF1-SHR conforme o peso corporal (~40% do PMC); e TF2-SHR conforme o teste de PMC (~70% do PMC). Foram coletadas medidas de PAS e a frequência cardíaca (FC) semanalmente usando o método de pressão arterial caudal. A progressão da força muscular foi determinada a cada 15 dias. O TF consistiu de 3 sessões semanais em dias não consecutivos durante 12 semanas. Resultados: Os dois protocolos de TF preveniram o aumento da PAS(respectivamente, delta - 5 e -7 mmHg; p > 0, 05), enquanto que a PAS do grupo SED-SHR aumentou em 19 mmHg (p 0, 05). Conclusões: Nossos dados indicam que ambos os protocolos de TF foram efetivos na prevenção da elevação crônica da PAS na HAG. Além disso, sobrecargas maiores de TF induziram a um maior aumento de força muscular.CapesCNPqUniv Catolica Brasilia, Programa Posgrad Educ Fis, Brasilia, DF, BrazilUniv Fed Sao Paulo, Programa Posgrad Med Translac, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Div Nefrol, Lab Imunol Clin & Expt, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Med, Div Nefrol, Sao Paulo, SP, BrazilUniv Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, SP, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Fisiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Programa Posgrad Med Translac, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Div Nefrol, Lab Imunol Clin & Expt, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Med, Div Nefrol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Fisiol, Sao Paulo, SP, BrazilWeb of Scienc

Isometric handgrip does not elicit cardiovascular overload or post-exercise hypotension in hypertensive older women

Background: Arterial hypertension is a serious health problem affecting mainly the elderly population. Recent studies have considered both aerobic and resistance exercises as a non-pharmacological aid for arterial hypertension treatment. However, the cardiovascular responses of the elderly to isometric resistance exercise (eg, isometric handgrip [IHG]) have not yet been documented. Objective: The purpose of this study was to investigate cardiovascular responses to different intensities of isometric exercise, as well as the occurrence of post-isometric exercise hypotension in hypertensive elderly people under antihypertensive medication treatment. Patients and methods: Twelve women volunteered to participate in the study after a maximal voluntary contraction test (MVC) and standardization of the intervention workload consisting of two sessions of IHG exercise performed in four sets of five contractions of a 10-second duration. Sessions were performed both at 30% of the MVC and 50% of the MVC, using a unilateral IHG protocol.\ud Both intensities were compared with a control session without exercise. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) at rest (R), during peak exercise (PE), and after 5, 10, 15, 30, 45, and 60 minutes of post-exercise recovery were evaluated. Results: No significant changes were observed after isometric exercise corresponding to 30% MVC for either SBP (R: 121 ± 10; PE: 127 ± 14; 5 min: 125 ± 13; 10 min: 123 ± 12; 15 min: 122 ± 11; 30 min: 124 ± 11; 45 min: 124 ± 10; 60 min: 121 ± 10 mmHg) or DBP (R: 74 ± 9; PE: 76 ± 6; 5 min: 74 ± 5; 10 min: 72 ± 8; 15 min: 72 ± 5; 30 min: 72 ± 8; 45 min: 73 ± 6; 60 min: 75 ± 7 mmHg). Similarly, the 50% MVC did not promote post-isometric exercise hypotension for either SBP (R: 120 ± 7; PE: 125 ± 11; 5 min: 120 ± 9; 10 min: 122 ± 9; 15 min: 121 ± 11; 30 min: 121 ± 9; 45 min: 121 ± 9; 60 min: 120 ± 7 mmHg) or DBP (R: 72 ± 8; PE: 78 ± 7; 5 min: 72 ± 7; 10 min: 72 ± 8; 15 min: 71 ± 7; 30 min: 72 ± 8; 45 min: 75 ± 10; 60 min: 75 ± 7 mmHg). Conclusion: Our data reveal that cardiovascular overload or post-exercise hypotension did not occur in elderly women with controlled hypertension when they undertook an IHG session. Thus this type of resistance exercise, with mild to moderate intensity, with short time of contraction appears to be safe for this populationFAPESP 2011/03528-0CAPE

Effect of swimming training on the cardiovascular system in normotensive rats

Resting bradycardia is considered to be a good marker of exercise training (ET) adaptation. However, the time course to heart rate (HR) and blood pressure (BP) responses occur during the exercise training period has not been clarified yet. Therefore, we studied 16 male normotensive Wistar rats. Eight rats were exercise trained (T) for 8 weeks, at a low intensity swimming protocol and 8 were kept sedentary (S). Systolic blood pressure and heart rate were measured two times per week during ET period by caudal measurements. The signal was recorded on a beat-to-beat basis (AT/CODAS) at a frequency of 100 Hz for 30 min in quiet and conscious rats. After ET, an arterial cannula was implanted for direct BP measurements and resting HR was studied using subcutaneously implanted electrodes. After BP and HR measurements, the rats were sacrificed and cardiac chambers were weighed in order to evaluate the cardiac hypertrophy. Maximal citrate synthase activity was measured in the soleus muscle to evaluate the oxidative muscle adaptation. Blood pressure was not changed by swimming training in normotensive rats. As expected, the resting HR was lower in T than in S rats (355±16 vs. 330±20 bpm). We observed increased left ventricle weight/body weight ratio in T rats (1.95 vs. 2.20 g/gBW) which represented 13% of left ventricle hypertrophy in T rats. The maximal citrate synthase activity increased 52% in the T rats. It was concluded that the swimming training for rats is a good experimental model to study the cardiovascular adaptations to dynamic exercise trainin

Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet

As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators. Exercise and caloric restriction are two important, nonpharmacological tools against body mass increase. To date, their effects on the immune cells of adipose tissue in obese organisms, specifically when a high-fat diet is consumed, have been poorly investigated. Thus, after consuming a high-fat diet, mice were submitted to chronic swimming training or a 30% caloric restriction in order to investigate the effects of both interventions on resident immune cells in adipose tissue. These strategies were able to reduce body mass and resulted in changes in the number of resident immune cells in the adipose tissue and levels of cytokines/chemokines in serum. While exercise increased the number of NK cells in adipose tissue and serum levels of IL-6 and RANTES, caloric restriction increased the CD4+/CD8+ cell ratio and MCP-1 levels. Together, these data demonstrated that exercise and caloric restriction modulate resident immune cells in adipose tissues differently in spite of an equivalent body weight reduction. Additionally, the results also reinforce the idea that a combination of both strategies is better than either individually for combating obesity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, BrazilUniv São Paulo, Sch Arts Sci & Humanities, BR-03828000 São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, Lab Transplantat Immunobiol, Dept Immunol, BR-05508900 São Paulo, BrazilUniv Fed Pelotas, Sch Nutr, Dept Nutr, BR-96010610 Pelotas, RS, BrazilUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, BrazilFAPESP: 2011/03528-0Web of Scienc