Psychological impact and health-related quality-of-life outcomes of Mayer-Rokitansky-Küster-Hauser syndrome : A systematic review and narrative synthesis

Mayer-Rokitansky-K\ufcster-Hauser syndrome causes absence or underdevelopment of uterus and vagina, but women's subjective experience remains understudied. This systematic review was conducted to examine the psychological and health-related quality-of-life outcomes of Mayer-Rokitansky-K\ufcster-Hauser syndrome. In total, 22 articles identified through electronic search matched the inclusion criteria and were included in our review. Mayer-Rokitansky-K\ufcster-Hauser syndrome may be associated with psychological symptoms and impaired quality of life, but especially with poor sexual esteem and genital image. Women may experience difficulties managing intimacy and disclosing to partners. Mothers may be perceived as overinvolved, with consequent negative emotions in women with the disease

The static and time-dependent signature of ocean–continent and ocean–ocean subduction: the case studies of Sumatra and Mariana complexes

SUMMARY The anomalous density structure at subduction zones, both in the wedge and in the upper mantle, is analysed to shed light on the processes that are responsible for the characteristic gravity fingerprints of two types of subduction: ocean–continent and ocean–ocean. Our modelling is then performed within the frame of the EIGEN-6C4 gravitational disturbance pattern of two subductions representative of the above two types, the Sumatra and Mariana complexes, finally enabling the different characteristics of the two patterns to be observed and understood on a physical basis, including some small-scale details. A 2-D viscous modelling perpendicular to the trench accounts for the effects on the gravity pattern caused by a wide range of parameters in terms of convergence velocity, subduction dip angle and lateral variability of the crustal thickness of the overriding plate, as well as compositional differentiation, phase changes and hydration of the mantle. Plate coupling, modelled within a new scheme where the relative velocity at the plate contact results self-consistently from the thermomechanical evolution of the system, is shown to have an important impact on the gravity signature. Beyond the already understood general bipolar fingerprint of subduction, perpendicular to the trench, we obtain the density and gravity signatures of the processes occurring within the wedge and mantle that are responsible for the two different gravity patterns. To be compliant with the geodetic EIGEN-6C4 gravitational disturbance and to compare our predictions with the gravity at Sumatra and Mariana, we define a model normal Earth. Although the peak-to-peak gravitational disturbance is comparable for the two types of subductions, approximately 250 mGal, from both observations and modelling, encompassing the highest positive maximum on the overriding plates and the negative minimum on the trench, the trough is wider for the ocean–ocean subduction: approximately 300 km compared to approximately 180 km for the ocean–continent subduction. Furthermore, the gravitational disturbance pattern is more symmetric for the ocean–ocean subduction compared to the ocean–continent subduction in terms of the amplitudes of the two positive maxima over the overriding and subducting plates. Their difference is, for the ocean–ocean type, approximately one half of the ocean–continent one. These different characteristics of the two types of subductions are exploited herein in terms of the different crustal thicknesses of the overriding plate and of the different dynamics in the wedge and in the mantle for the two types of subduction, in close agreement with the gravity data

The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols

The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum

Assessing opportunities and weaknesses of green hydrogen transport via LOHC through a detailed techno-economic analysis

In the transition towards a more sustainable energy system, hydrogen is seen as the key low-emission energy source. However, the limited H2 volumetric density hinders its transportation. To overcome this issue, liquid organic hydrogen carriers (LOHCs), molecules that can be hydrogenated and, upon arrival, dehydrogenated for H2 release, have been proposed as hydrogen transport media. Considering toluene and dibenzyltoluene as representative carriers, this work offers a systematic methodology for the analysis and the comparison of LOHCs, in view of identifying cost-drivers of the overall value-chain. A detailed Aspen Plus process simulation is provided for hydrogenation and dehydrogenation sections. Simulation results are used as input data for the economic assessment. The process economics reveals that dehydrogenation is the most impactful cost-item, together with the carrier initial loading, the latter related to the LOHC transport distance. The choice of the most suitable molecule as H2 carrier, ultimately, is a trade-off between its hydrogenation enthalpy and cost.(c) 2023 The Author(s). Published by Elsevier Ltd on behalf of Hydrogen Energy Publications LLC. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)