An exploration into the client at the heart of therapy : a qualitative perspective

Over 50 years ago Eysenck challenged the existing base of research into psychotherapy. Since that time, a large number of investigations have been conducted to verify the efficacy of therapy. Recently however, an increasing number of studies have cast new doubts on this research base. Instead of therapy being a function of the therapist, it is now becoming ever more apparent that the client plays a prime role in the therapeutic process. The qualitative studies presented in this paper provide some examples of research that demonstrates that clients are actively involved in their therapy, even making counselling work despite their counsellor. These studies suggest that clients may not experience therapy as beneficially as traditional outcome studies indicate. This raises a new challenge to researchers to more fully explore the client's experience of therapy, a challenge to which qualitative methods of inquiry would appear well suited

Utilizing ERTS imagery to detect plant diseases and nutrient deficiencies, soil types and soil moisture levels

The author has identified the following significant results. ERTS-1 imagery may be used to delineate soil associations. It does have the capacity to divide soils into groups such that their land use and management would be similar. It offers definite potential for making grass flood-plain, wetland, river shoreline, and land use change surveys. Production of volume strata and forest type from the two usable bands of ERTS-1 imagery were of questionable value. No imagery was received for evaluation during the time of year when maine dwarf mosaic virus and southern corn leaf blight were active

Utilizing ERTS imagery to detect plant diseases and nutrient deficiencies, soil types and soil moisture levels

There are no author-identified significant results in this report

Regional and Developmental Differences in Na+ Currents in Vestibular Primary Afferent Neurons

The vestibular system relays information about head position via afferent nerve fibers to the brain in the form of action potentials. Voltage-gated Na+ channels in vestibular afferents drive the initiation and propagation of action potentials, but their expression during postnatal development and their contributions to firing in diverse mature afferent populations are unknown. Electrophysiological techniques were used to determine Na+ channel subunit types in vestibular calyx-bearing afferents at different stages of postnatal development. We used whole cell patch clamp recordings in thin slices of gerbil crista neuroepithelium to investigate Na+ channels and firing patterns in central zone (CZ) and peripheral zone (PZ) afferents. PZ afferents are exclusively dimorphic, innervating type I and type II hair cells, whereas CZ afferents can form dimorphs or calyx-only terminals which innervate type I hair cells alone. All afferents expressed tetrodotoxin (TTX)-sensitive Na+ currents, but TTX-sensitivity varied with age. During the fourth postnatal week, 200–300 nM TTX completely blocked sodium currents in PZ and CZ calyces. By contrast, in immature calyces [postnatal day (P) 5–11], a small component of peak sodium current remained in 200 nM TTX. Application of 1 μM TTX, or Jingzhaotoxin-III plus 200 nM TTX, abolished sodium current in immature calyces, suggesting the transient expression of voltage-gated sodium channel 1.5 (Nav1.5) during development. A similar TTX-insensitive current was found in early postnatal crista hair cells (P5–9) and constituted approximately one third of the total sodium current. The Nav1.6 channel blocker, 4,9-anhydrotetrodotoxin, reduced a component of sodium current in immature and mature calyces. At 100 nM 4,9-anhydrotetrodotoxin, peak sodium current was reduced on average by 20% in P5–14 calyces, by 37% in mature dimorphic PZ calyces, but by less than 15% in mature CZ calyx-only terminals. In mature PZ calyces, action potentials became shorter and broader in the presence of 4,9-anhydrotetrodotoxin implicating a role for Nav1.6 channels in firing in dimorphic afferents

Families of type III KMS states on a class of C-algebras containing On and QN

We construct a family of purely infinite C¤-algebras, Q¸ for ¸ 2 (0, 1) that are classified by their K-groups. There is an action of the circle T with a unique KMS state à on each Q¸. For ¸ = 1/n, Q1/n »= On, with its usual T action and KMS state. For ¸ = p/q, rational in lowest terms, Q¸ »= On (n = q − p + 1) with UHF fixed point algebra of type (pq)1. For any n \u3e 1, Q¸ »= On for infinitely many ¸ with distinct KMS states and UHF fixed-point algebras. For any ¸ 2 (0, 1), Q¸ 6= O1. For ¸ irrational the fixed point algebras, are NOT AF and the Q¸ are usually NOT Cuntz algebras. For ¸ transcendental, K1(Q¸) »= K0(Q¸) »= Z1, so that Q¸ is Cuntz\u27 QN, [Cu1]. If ¸ and ¸−1 are both algebraic integers, the only On which appear are those for which n ´ 3(mod 4). For each ¸, the representation of Q¸ defined by the KMS state à generates a type III¸ factor. These algebras fit into the framework of modular index theory / twisted cyclic theory of [CPR2, CRT] and [CNNR]

Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Original article can be found at: http://journals.cambridge.org/action/displayJournal?jid=PHN Copyright The Authors. DOI: 10.1079/PHN2002439Peer reviewe

Tamoxifen, 17beta-oestradiol and the calmodulin antagonist J8 inhibit human melanoma cell invasion through fibronectin.

Invasion through stromal extracellular matrix (ECM) is part of the complex, multistep process of tumour cell invasion and metastasis. Our group has previously demonstrated that calcium and calmodulin are important in another step in the metastatic cascade - that of attachment of cells to ECM. Interestingly, the non-steroidal anti-oestrogen tamoxifen (which also has calmodulin antagonist activity), used in the treatment of breast cancer and now in metastatic cutaneous melanoma, can inhibit the attachment of normal and neoplastic cells to ECM. In this study, we investigated whether such drugs, known to inhibit cell attachment, could also subsequently reduce their invasion through a layer of human fibronectin. We examined the ability of the specific calmodulin antagonist J8, tamoxifen and its two major metabolites, N-desmethyltamoxifen (N-des) and 4-hydroxytamoxifen (4-OH), as well as the pure anti-oestrogen ICI 182,780 and 17beta-oestradiol to inhibit invasion of the human cutaneous melanoma cell line, A375-SM, uveal melanoma cells and uveal melanocytes. A375-SM cells and uveal melanoma cells showed a high level of invasion (15.2% and 33.7% respectively) compared with melanocytes (around 5%) under the experimental conditions used. Submicromolar concentrations of N-des, tamoxifen, J8 and 17beta-oestradiol significantly reduced the invasiveness of the A375-SM cell line. The uveal melanoma cells also showed similar inhibition, although at higher concentrations of these agents. 4-OH and ICI 182, 780 had little or no effect on invasion of A375-SM cells (these were not tested on uveal melanoma cells). All cells used in this study were found to be negative for type I nuclear oestrogen receptors, reinforcing the possibility that tamoxifen and 17beta-oestradiol can act via mechanisms unrelated to binding to classical oestrogen receptors to inhibit tumour cell invasion

Housing system, milk production, and zero-grazing effects on lameness and leg injury in dairy cows

The aim of this study was to assess the effect of grazing (G) vs. zero-grazing (ZG), level of milk production,and quality and type of housing system [free stalls (FS)and straw yards (SY)] on the prevalence of lamenessand leg injuries in dairy cows. Observations were madeon 37 commercial dairy farms across Great Britain. Asingle visit of 5 d duration was made to each farm.During this visit, lameness scores and the incidence ofswellings, rubs, and injuries to hocks and knees wererecorded on all the peak- or mid-lactation cows. Aspectsof the quality of housing and management that werelikely to affect foot and leg health were recorded. Therewere more lame cows on ZG farms (39 ± 0.02%) thanon grazing (G) farms (15 ± 0.01%), and lameness scoreswere higher on FS farms compared with SY farms (0.25± 0.01 vs. 0.05 ± 0.01). Cows on SY farms had fewerhock and knee injuries compared with FS farms. The frequency of knee swellings was higher on ZG farms(0.31 ± 0.02) than on G farms (0.15 ± 0.01). Aspects of the free-stall design affected foot and leg health. The number of hock swellings increased with increasing stall gradient (0.16 ± 0.01 with no slope vs. 0.39 ± 0.02at a 0 to 1.5% slope). There was an interaction between the length of the free-stall lunging space and the hip width of the cow, indicating that the incidence of lameness is generally highest on farms with small free stalls and heavy cows. High levels of milk production did not affect lameness or leg injury. The results indicate that housing cows throughout the year potentially has adetrimental effect on foot and leg health. However, good free-stall design may reduce lameness and leg lesion