Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?

Carbon nanotubes (CNTs), the product of new technology, may be used in a wide range of applications. Because they present similarities to asbestos fibres in terms of their shape and size, it is legitimate to raise the question of their safety for human health. Recent animal and cellular studies suggest that CNTs elicit tissue and cell responses similar to those observed with asbestos fibres, which increases concern about the adverse biological effects of CNTs. While asbestos fibres' mechanisms of action are not fully understood, sufficient results are available to develop hypotheses about the significant factors underlying their damaging effects. This review will summarize the current state of knowledge about the biological effects of CNTs and will discuss to what extent they present similarities to those of asbestos fibres. Finally, the characteristics of asbestos known to be associated with toxicity will be analyzed to address the possible impact of CNTs

Colonization of meat by enterohaemorrhagic Escherichia coli O157

International audienceEnterohemorrhagic Escherichia coli (EHEC) are anthropozoonotic agent responsible for recurrent foodpoisoning often caused by contaminated burgers. EHEC infection is essentially a pediatric illness, which can lead to life-threatening pathologies. Runimants are the main natural reservoir for EHEC and primary bacterial contamination occurs of meat at the dehiding stage of slaughtering.The extracellular matrix (ECM) is the most exposed part of the skeletal muscles in beef carcasses. This study aimed at investigating bacterial colonization to the skeletal-muscle extracellular matrix (ECM) proteins and muscle tissue, it appeared that environmental factors influenced specific and non-specific bacterial adhesion of O157 and non-O157 EHEC as well as biofilm formation

La colonisation de la viande par Escherichia coli O157:H7 : Rôle clé de la matrice extracellulaire

National audienc

Colonisation of meat by Escherichia coli O157:H7: bacterial tropism respective to the different types of skeletal muscles, subtypes of myofibers and postmortem time

International audienc

Contamination de la viande par Escherichia coli O157:H7 : Rôle clé de la matrice extracellulaire dans l’adhésion au tissu musculaire

National audienc

Colonisation of meat by escherichia coli O157:H7: Investigating bacterial tropism with respect to the different types of skeletal mMuscles, Subtypes of mMyofibres, and postmortem time

Escherichia coli O157:H7 is an enterohaemorrhagic E. coli (EHEC) responsible for serious diseases, especially pediatric, and of great concern for the meat industry.Meat contamination by EHEC occurs at slaughtering, especially at dehiding stage, where bacteria can be transferred from hides to carcasses. The skeletal muscle tissues comprise four major types of myofibres, which differ in their contraction velocity and metabolism. Myofibres are surrounded by the extracellular matrix (ECM). Adhesion of E. coli O157:H7 to meat was investigated considering well-defined types of skeletal muscle and their constituent myofibres as well as postmortem changes in muscle, using fluorescence microscopy and immunohistochemical analyses. By analysing the adhesion of E. coli O157:H7 to model oxidative (soleus) and glycolytic [extensor digitorum longus (EDL)] skeletal muscles, it first appeared that differential adhesion occurred at the surface of these extreme skeletal muscle types. At a cellular level, bacterial adhesion appeared to occur essentially at the ECM. Considering the different constituent myofibres of types I, IIA, IIX and IIB, no significant differences were observed for adhering bacteria. However, bacterial adhesion to the ECM was significantly influenced by postmortem structural modifications of muscle tissues. By providing information on spatial localisation of E. coli O157:H7 on meat, this investigation clearly demonstrated their ability to adhere to skeletal muscle, especially at the ECM, which consequently resulted in their heterogeneous distribution in meat. As discussed, these new findings should help in reassessing and mitigating the risk of contamination of meat, the food chain and ultimately human infection by EHEC

Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours

International audienc

Similar Tumor Suppressor Gene Alteration Profiles in Asbestos-Induced Murine and Human Mesothelioma

International audienc