Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography

Chantier qualité GAInternational audienceRecurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In ~50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of mammalian reproduction. Indeed, fertility can be considered as a quantitative feature resulting from the interaction of genetic, epigenetic and environmental factors. Herein, we identified Quantitative Trait Loci (QTL) associated with diverse embryonic lethality phenotypes and the subsequent embryonic resorption in 39 inter-specific recombinant congenic mice strains, using in vivo ultrasound bio-microscopy. The short chromosomal intervals related to the phenotypes will facilitate the study of a restricted number of candidate genes which are potentially dysregulated in patients affected by RSA

The Giant Radio Array for Neutrino Detection

High-energy neutrino astronomy will probe the working of the most violent phenomena in the Universe. The Giant Radio Array for Neutrino Detection (GRAND) project consists of an array of ∼ 105 radio antennas deployed over ∼ 200 000 km2 in a mountainous site. It aims at detecting high-energy neutrinos via the measurement of air showers induced by the decay in the atmosphere of τ leptons produced by the interaction of cosmic neutrinos under the Earth surface. Our objective with GRAND is to reach a neutrino sensitivity of 5 × 10−11E−2 GeV−1 cm−2 s−1 sr−1 above 3 × 1016 eV. This sensitivity ensures the detection of cosmogenic neutrinos in the most pessimistic source models, and up to 100 events per year are expected for the standard models. GRAND would also probe the neutrino signals produced at the potential sources of UHECRs

Genomic Characterization of the Taylorella Genus

The Taylorella genus comprises two species: Taylorella equigenitalis, which causes contagious equine metritis, and Taylorella asinigenitalis, a closely-related species mainly found in donkeys. We herein report on the first genome sequence of T. asinigenitalis, analyzing and comparing it with the recently-sequenced T. equigenitalis genome. The T. asinigenitalis genome contains a single circular chromosome of 1,638,559 bp with a 38.3% GC content and 1,534 coding sequences (CDS). While 212 CDSs were T. asinigenitalis-specific, 1,322 had orthologs in T. equigenitalis. Two hundred and thirty-four T. equigenitalis CDSs had no orthologs in T. asinigenitalis. Analysis of the basic nutrition metabolism of both Taylorella species showed that malate, glutamate and alpha-ketoglutarate may be their main carbon and energy sources. For both species, we identified four different secretion systems and several proteins potentially involved in binding and colonization of host cells, suggesting a strong potential for interaction with their host. T. equigenitalis seems better-equipped than T. asinigenitalis in terms of virulence since we identified numerous proteins potentially involved in pathogenicity, including hemagluttinin-related proteins, a type IV secretion system, TonB-dependent lactoferrin and transferrin receptors, and YadA and Hep_Hag domains containing proteins. This is the first molecular characterization of Taylorella genus members, and the first molecular identification of factors potentially involved in T. asinigenitalis and T. equigenitalis pathogenicity and host colonization. This study facilitates a genetic understanding of growth phenotypes, animal host preference and pathogenic capacity, paving the way for future functional investigations into this largely unknown genus

ETUDE DE LA PHOTOACTIVITE DU DIOXYDE DE TITANE TIO 2 (APPORT DE LA RESONANCE PARAMAGNETIQUE ELECTRONIQUE)

PARIS-BIUSJ-Physique recherche (751052113) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF

Questões atuais sobre as posições do Ministério Público no Processo Civil

- Disponível também na Revista de Processo: RePro, São Paulo, v. 39, n. 237, p. 45-87, nov. 2014