Production of polymer filament-shaped piezoelectric sensors for e-textiles applications

This work aims at the development of piezoelectric materials for flexible sensors produced with various geometries, at low cost and high production rates, adequate for the industrial scale. In particular the filament form, appropriate for integration into textiles, is described, but other geometries, such as tape, are also being studied. The filaments are produced by co-extrusion of multiple layers with piezoelectric and electrically conductive polymer composites.Fundação para a Ciência e a Tecnologia (FCT) - PTDC/CTM/108801/200

Piezoelectric filaments produced by coextrusion

Considering the significant interest of both the academic and industrial communities in the fields of i/e-textiles (interactive/electronic textiles), the number of developed applications is far below the expected. This fact is mainly related to the difficulties on the development of production methodologies adequate to industrial scale processes. In this areas the integration of piezoelectric materials, that possess sensing/actuating capabilities, such as poly(vinylidene fluoride), PVDF, and can be processed using conventional processing techniques, is very promising and has encouraged a large number of research works. However, until now, most of the developed production methodologies are difficult to adapt to the industrial scale. This work reports recent developments achieved, in the framework of a research project, on the production of piezoelectric filament by coextrusion of PVDF and electrical conductive layers. The developed production methodology involves a conventional coextrusion line, for which a coextrusion die was designed to produce a multilayer filament. This filament comprises an inner layer of an electrically conductive Polypropylene grade and a middle layer of PVDF and is coated with an electrical conductive ink. The piezoelectric response of the produced filaments will be also presentedFundação para a Ciência e a Tecnologia (FCT)- FCT PTDC/CTM/108801/200

Coextrusion of polymeric piezoelectric filaments

The difficulties related to the development of industrial scalable production methodologies have limited the number of applications currently available in the field of interactive/electronic textiles, which are far below the anticipated a few years ago. In these areas the integration of piezoelectric materials, that possess sensing/actuating capabilities, such as poly(vinylidene fluoride), PVDF, and can be processed using conventional processing techniques, is very promising and has encouraged a large number of research works. However, until now, most of the developed production methodologies are difficult to adapt to the industrial scale. This work reports recent developments achieved in the framework of a research project, on the production of piezoelectric filament by coextrusion of PVDF and an electrically conductive thermoplastic. The developed production methodology is based on a conventional coextrusion line, for which a coextrusion die was designed to produce a multilayer filament, which comprises an inner layer of an electrically conductive Polypropylene grade and a middle layer of PVDF and is coated with an electrical conductive ink. The sensing capabilities of the produced filaments are also characterized.Fundação para a Ciência e a Tecnologia (FCT)- FCT PTDC/CTM/108801/200

Distribuição de oligoquetas em um riacho da mata atlântica, sudestedo brasi

The oligochaetes are considered good indicators of ecological conditions and specific types of habitats. Among the factors that influence the distribution of these invertebrates are the water flow and the nature of the substrate. The aim of this study is to describe the composition and distribution of oligochaete species in a first-order stream in Atlantic Forest and try to identify if some species are associated with characteristics of particular types of habitats. In the dry season and in the rainy season, sand and litter samples in two riffle areas and two pool areas were collected in different parts along the stream using a hand net. The greatest observed richness and abundance occurred in sand in the pool, however the greatest estimated richness was obtained for litter in the pool. The Kruskal-Wallis analysis showed effect of the different types of habitat on the abundance and richness of oligochaetes. The Nonmetric Multidimensional Scaling (NMDS) and Multiresponse Permutation Procedure analysis (MRPP) indicated that the variation in the fauna composition had relation with different types of substrates. The indicator species analysis showed that Limnodrilus. hoffmeisteri was an indicator species in both the riffle sand and pool sand and Pristina americana was only an indicator in the pool sand. The high organic matter content in both sandy habitats probably favored the greater abundance of oligochaetes. The results showed that the substrate constitutes an important factor for the local distribution of these invertebrates in streams. The variation of the community structure among mesohabitats and the presence of indicator species of specific types of habitats in the stream demonstrate the importance of environmental heterogeneity for the oligochaetes fauna in forested streams. © 2015 Instituto Internacional de Ecologia. All Right reserved

Opinion Dynamics of Learning Agents: Does Seeking Consensus Lead to Disagreement?

We study opinion dynamics in a population of interacting adaptive agents voting on a set of complex multidimensional issues. We consider agents which can classify issues into for or against. The agents arrive at the opinions about each issue in question using an adaptive algorithm. Adaptation comes from learning and the information for the learning process comes from interacting with other neighboring agents and trying to change the internal state in order to concur with their opinions. The change in the internal state is driven by the information contained in the issue and in the opinion of the other agent. We present results in a simple yet rich context where each agent uses a Boolean Perceptron to state its opinion. If there is no internal clock, so the update occurs with asynchronously exchanged information among pairs of agents, then the typical case, if the number of issues is kept small, is the evolution into a society thorn by the emergence of factions with extreme opposite beliefs. This occurs even when seeking consensus with agents with opposite opinions. The curious result is that it is learning from those that hold the same opinions that drives the emergence of factions. This results follows from the fact that factions are prevented by not learning at all from those agents that hold the same opinion. If the number of issues is large, the dynamics becomes trapped and the society does not evolve into factions and a distribution of moderate opinions is observed. We also study the less realistic, but technically simpler synchronous case showing that global consensus is a fixed point. However, the approach to this consensus is glassy in the limit of large societies if agents adapt even in the case of agreement.Comment: 16 pages, 10 figures, revised versio

A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancer

BACKGROUND: In non-small cell lung cancer (NSCLC), interstitial hypertension is a barrier to chemotherapy delivery, and is mediated by platelet derived growth factor receptor (PDGFR). Antagonizing PDGFR with imatinib may improve intra-tumoral delivery of paclitaxel, increasing response rate (RR). METHODS: This single-stage, open-label phase II study evaluated pulse dose imatinib and weekly paclitaxel in elderly patients with advanced NSCLC. Eligible patients were aged ≥ 70 with untreated, stage IIIB-IV NSCLC and ECOG performance status 0-2. Primary endpoint was RR. Secondary endpoints included median progression free and overall survival (PFS, OS) and correlatives of PDGFR pathway activation. Baseline Charlson Comorbidity Index (CCI) and Vulnerable Elder Survey-13 (VES-13) were correlated with outcomes. RESULTS: Thirty-four patients with median age 75 enrolled. Eleven of 29 (38%) were frail by VES-13 score. Overall RR was 11/34 (32%; 95% CI 17%-51%), meeting the primary endpoint. Median PFS and OS were 3.6 and 7.3 months, respectively. High tumoral PDGF-B expression predicted inferior PFS. Frail patients by VES-13 had significantly worse median PFS (3.2 vs. 4.5 months; p=0.02) and OS (4.8 vs. 12 months; p=0.02) than non-frail. CONCLUSIONS: The combination of imatinib and paclitaxel had encouraging activity as measured by the primary endpoint of RR. However, PFS and OS were typical for elderly patients treated with single agent chemotherapy and the regimen is not recommended for further study. Adjunct imatinib did not overcome the established association of tumoral PDGF-B expression with inferior PFS. VES-13 was a powerful predictor of poor survival outcomes. Frailty should be further studied as a predictor of non-benefit from chemotherapy. TRIAL REGISTRATION: ClinicalTrials.gov NCT01011075

Co-axial piezoelectric sensors for e-textiles applications

This work reports on the development of piezoelectric filaments for flexible sensors produced at high production rates, adequate for the industrial scale.Fundação para a Ciência e a Tecnologia (FCT) - FCT PTDC/CTM/108801/200

Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases

Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.CNPq [300546/2012-2, 304465/2012-7, 476877/2012-1]FAPESP [2010/14831-3, 2011/15817-7, 2008/55359-5]Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, BrazilSchool of Medicine, University of São Paulo, São Paulo-SP 01246903, BrazilInstituto de Saúde e Sociedade, Federal University of São Paulo, Santos-SP 11015-020, BrazilInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, BrazilInstituto de Saúde e Sociedade, Federal University of São Paulo, Santos-SP 11015-020, BrazilCNPq: 300546/2012-2CNPq: 304465/2012-7CNPq: 476877/2012-1FAPESP: 2010/14831-3FAPESP: 2011/15817-7FAPESP: 2008/55359-5Web of Scienc

It Takes Two to Tango, Part II : Synthesis of A-Ring Functionalised Quinones Containing Two Redox-Active Centres with Antitumour Activities

In 2021, our research group published the prominent anticancer activity achieved through the successful combination of two redox centres (ortho-quinone/para-quinone or quinone/seleniumcontaining triazole) through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The combination of two naphthoquinoidal substrates towards a synergetic product was indicated, but not fully explored. Herein, we report the synthesis of 15 new quinone-based derivatives prepared from click chemistry reactions and their subsequent evaluation against nine cancer cell lines and the murine fibroblast line L929. Our strategy was based on the modification of the A-ring of paranaphthoquinones and subsequent conjugation with different ortho-quinoidal moieties. As anticipated, our study identified several compounds with IC50 values below 0.5 µM in tumour cell lines. Some of the compounds described here also exhibited an excellent selectivity index and low cytotoxicity on L929, the control cell line. The antitumour evaluation of the compounds separately and in their conjugated form proved that the activity is strongly enhanced in the derivatives containing two redox centres. Thus, our study confirms the efficiency of using A-ring functionalized para-quinones coupled with ortho-quinones to obtain a diverse range of two redox centre compounds with potential applications against cancer cell lines. Here as well, it literally takes two for an efficient tango