Epstein–Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: a review

In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified—virus detection is required for the diagnosis, while in others its detection is not necessary for diagnosis. EBV infection has three main latency patterns (types III, II, and I). Different latency patterns are found in different LPD types and are related to the host immune system status. For each of the LPDs/lymphomas, we discuss the clinical presentation, epidemiology, pathology, immunophenotype, and genetic or molecular basis. We provide data for a better understanding of the relationships among the discussed diseases and other information that can be useful in differential diagnosis. Not included in this review are classic Hodgkin lymphoma and some specific variants of DLBCL, as these entities are discussed in separate reviews in this issue

Constraints on the KS0→μ+μ−K^0_S \rightarrow \mu^+ \mu^- Branching Fraction

International audienceA search for the decay KS0→μ+μ- is performed using proton-proton collision data, corresponding to an integrated luminosity of 5.6  fb-1 and collected with the LHCb experiment during 2016, 2017, and 2018 at a center-of-mass energy of 13 TeV. The observed signal yield is consistent with zero, yielding an upper limit of B(KS0→μ+μ-)<2.2×10-10 at 90% C.L.. The limit reduces to B(KS0→μ+μ-)<2.1×10-10 at 90% C.L. once combined with the result from data taken in 2011 and 2012

Observation of the Λb0→χc1(3872)pK−\Lambda_b^0\rightarrow \chi_{c1}(3872)pK^- decay

International audienceUsing proton-proton collision data, collected with the LHCb detector and corresponding to 1.0, 2.0 and 1.9 fb$^{−1}$ of integrated luminosity at the centre-of-mass energies of 7, 8, and 13 TeV, respectively, the decay {\Lambda}_{\mathrm{b}}^0\to {\upchi}_{\mathrm{c}1} (3872)pK$^{−}$ with χ$_{c1}$(3872) → J/ψ π$^{+}$π$^{−}$ is observed for the first time. The significance of the observed signal is in excess of seven standard deviations. It is found that (58 ± 15)% of the decays proceed via the two-body intermediate state χ$_{c1}$(3872)Λ(1520). The branching fraction with respect to that of the ${\Lambda}_{\mathrm{b}}^0$ → ψ(2S)pK$^{−}$ decay mode, where the ψ(2S) meson is reconstructed in the J/ψ π$^{+}$π$^{−}$ final state, is measured to be: $ \frac{\beta \left({\Lambda}_{\mathrm{b}}^0\to {\upchi}_{\mathrm{c}1}(3872){\mathrm{pK}}^{-}\right)}{\beta \left({\Lambda}_{\mathrm{b}}^0\to \uppsi \left(2\mathrm{S}\right){\mathrm{pK}}^{-}\right)}\times \frac{\beta \left({\upchi}_{\mathrm{c}1}(3872)\to \mathrm{J}/\uppsi {\uppi}^{+}{\uppi}^{-}\right)}{\beta \left(\uppsi \left(2\mathrm{S}\right)\to \mathrm{J}/\uppsi {\uppi}^{+}{\uppi}^{-}\right)}=\left(5.4\pm 1.1\pm 0.2\right)\times {10}^{-2},

Measurement of fs/fuf_s / f_u Variation with Proton-Proton Collision Energy and BB-Meson Kinematics

International audienceThe ratio of the Bs0 and B+ fragmentation fractions fs and fu is studied with Bs0→J/ψϕ and B+→J/ψK+ decays using data collected by the LHCb experiment in proton-proton collisions at 7, 8, and 13 TeV center-of-mass energies. The analysis is performed in bins of B-meson momentum, longitudinal momentum, transverse momentum, pseudorapidity, and rapidity. The fragmentation-fraction ratio fs/fu is observed to depend on the B-meson transverse momentum with a significance of 6.0σ. This dependency is driven by the 13 TeV sample (8.7σ), while the results for the other collision energies are not significant when considered separately. Furthermore, the results show a 4.8σ evidence for an increase of fs/fu as a function of collision energy

Measurement of the branching fraction of the decay Bs0→KS0KS0B_s^0\to K_S^0 K_S^0

International audienceA measurement of the branching fraction of the decay Bs0→KS0KS0 is performed using proton–proton collision data corresponding to an integrated luminosity of 5  fb-1 collected by the LHCb experiment between 2011 and 2016. The branching fraction is determined to be B(Bs0→KS0KS0)=[8.3±1.6(stat)±0.9(syst)±0.8(norm)±0.3(fs/fd)]×10-6, where the first uncertainty is statistical, the second is systematic, and the third and fourth are due to uncertainties on the branching fraction of the normalization mode B0→ϕKS0 and the ratio of hadronization fractions fs/fd. This is the most precise measurement of this branching fraction to date. Furthermore, a measurement of the branching fraction of the decay B0→KS0KS0 is performed relative to that of the Bs0→KS0KS0 channel, and is found to be B(B0→KS0KS0)B(Bs0→KS0KS0)=[7.5±3.1(stat)±0.5(syst)±0.3(fs/fd)]×10-2

Test of lepton universality with Λb0→pK−ℓ+ℓ− {\Lambda}_b^0\to {pK}^{-}{\mathrm{\ell}}^{+}{\mathrm{\ell}}^{-} decays

International audienceThe ratio of branching fractions of the decays ${\Lambda}_b^0$ → pK$^{−}$e$^{+}$e$^{−}$ and ${\Lambda}_b^0$ → pK$^{−}$μ$^{+}$μ$^{−}$,${R}_{pK}^{-1}$, is measured for the first time using proton-proton collision data corresponding to an integrated luminosity of 4.7 fb$^{−1}$ recorded with the LHCb experiment at center-of-mass energies of 7, 8 and 13 TeV. In the dilepton mass-squared range 0.1 < q$^{2}$< 6.0 GeV$^{2}$/c$^{4}$ and the pK$^{−}$ mass range m(pK$^{−}$) < 2600 MeV/c$^{2}$, the ratio of branching fractions is measured to be ${R}_{pK}^{-1}={1.17}_{-0.16}^{+0.18}\pm 0.07$, where the first uncertainty is statistical and the second systematic. This is the first test of lepton universality with b baryons and the first observation of the decay ${\Lambda}_b^0$ → pK$^{−}$e$^{+}$e$^{−}$.[graphic not available: see fulltext

Updated measurement of time-dependent CP-violating observables in Bs0→J/ψK+K−B^{0}_{s}\to J/\psi K^+ K^- decays

International audienceThe decay-time-dependent $CP$ asymmetry in ${{B} ^0_{s}} \rightarrow J/\psi {{K} ^+} {{K} ^-}$ decays is measured using proton–proton collision data, corresponding to an integrated luminosity of $1.9\,\mathrm{fb}^{-1}$ , collected with the LHCb detector at a centre-of-mass energy of $13\,\mathrm {TeV}$ in 2015 and 2016. Using a sample of approximately 117 000 signal decays with an invariant ${{K} ^+} {{K} ^-}$ mass in the vicinity of the $\phi (1020)$ resonance, the $CP$ -violating phase $\phi _s$ is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the ${{B} ^0_{s}}$ - ${{\overline{B}{}} {}^0_{s}}$ system, $\Delta \Gamma _s$ . The difference of the average ${{B} ^0_{s}}$ and ${{B} ^0}$ meson decay widths, $\Gamma _s-\Gamma _d$ , is determined using in addition a sample of ${{B} ^0} \rightarrow J/\psi {{K} ^+} {{\pi } ^-}$ decays. The values obtained are $\phi _s = -0.083\pm 0.041\pm 0.006\mathrm { \,rad}$ , $\Delta \Gamma _s = 0.077 \pm 0.008 \pm 0.003 {\mathrm { \,ps^{-1}}}$ and $\Gamma _s-\Gamma _d = -0.0041 \pm 0.0024 \pm 0.0015{\mathrm { \,ps^{-1}}}$ , where the first uncertainty is statistical and the second systematic. These are the most precise single measurements of these quantities to date and are consistent with expectations based on the Standard Model and with a previous LHCb analysis of this decay using data recorded at centre-of-mass energies 7 and 8 TeV. Finally, the results are combined with recent results from ${{B} ^0_{s}} \rightarrow J/\psi {{\pi } ^+} {{\pi } ^-}$ decays obtained using the same dataset as this analysis, and with previous independent LHCb results

Measurement of the Λb0→J/ψΛ\Lambda^0_b\rightarrow J/\psi\Lambda angular distribution and the Λb0\Lambda^0_b polarisation in pppp collisions

International audienceThis paper presents an analysis of the ${\Lambda}_b^0$→ J/ψΛ angular distribution and the transverse production polarisation of ${\Lambda}_b^0$ baryons in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV. The measurements are performed using data corresponding to an integrated luminosity of 4.9 fb$^{−1}$, collected with the LHCb experiment. The polarisation is determined in a fiducial region of ${\Lambda}_b^0$ transverse momentum and pseudorapidity of 1 < p$_{T}$< 20 GeV/c and 2 < η < 5, respectively. The data are consistent with ${\Lambda}_b^0$ baryons being produced unpolarised in this region. The parity-violating asymmetry parameter of the Λ → pπ$^{−}$ decay is also determined from the data and its value is found to be consistent with a recent measurement by the BES III collaboration.[graphic not available: see fulltext