7 research outputs found
A Prospective Randomized Controlled Trial of the Effects of Vitamin D Supplementation on Cardiovascular Disease Risk
Vitamin D (VitD) supplementation has been advocated for cardiovascular risk reduction; however, supporting data are sparse. The objective of this study was to determine whether VitD supplementation reduces cardiovascular risk. Subjects in this prospective, randomized, double-blind, placebo-controlled trial of post-menopausal women with serum 25-hydroxyvitamin D concentrations >10 and <60 ng/mL were randomized to Vitamin D3 2500 IU or placebo, daily for 4 months. Primary endpoints were changes in brachial artery flow-mediated vasodilation (FMD), carotid-femoral pulse wave velocity (PWV), and aortic augmentation index (AIx). The 114 subjects were mean (standard deviation) 63.9 (3.0) years old with a 25-hydroxyvitamin D level of 31.3 (10.6) ng/mL. Low VitD (<30 ng/mL) was present in 47% and was associated with higher body-mass index, systolic blood pressure, glucose, CRP, and lower FMD (all p<0.05). After 4 months, 25-hydroxyvitamin D levels increased by 15.7 (9.3) ng/mL on vitamin D3 vs. β0.2 (6.1) ng/mL on placebo (p<0.001). There were no significant differences between groups in changes in FMD (0.3 [3.4] vs. 0.3 [2.6] %, pβ=β0.77), PWV (0.00 [1.06] vs. 0.05 [0.92] m/s, pβ=β0.65), AIx (2.7 [6.3] vs. 0.9 [5.6] %, pβ=β0.10), or CRP (0.3 [1.9] vs. 0.3 [4.2] mg/L, pβ=β0.97). Multivariable models showed no significant interactions between treatment group and low VitD status (<30 ng/mL) for changes in FMD (pβ=β0.65), PWV (pβ=β0.93), AIx (pβ=β0.97), or CRP (pβ=β0.26).In conclusion, VitD supplementation did not improve endothelial function, arterial stiffness, or inflammation. These observations do not support use of VitD supplementation to reduce cardiovascular disease risk
N-[2-Naphthyl]-glycine hydrazide, a potent inhibitor of DNA-dependent RNA polymerase ofMycobacterium tuberculosis H37RV
CONSORT 2010 Flow Diagram.
<p>The first 34 subjects were part of a pilot study performed under NCT 00690417. The remainder of the subjects were performed under NCT 01049048.</p
Baseline Subject Characteristics.
<p>All values are means (standard deviations).</p>*<p>Central blood pressures and stiffness measurements were obtained from 37 subjects in the placebo and 38 subjects in the vitamin D arms, respectively.</p><p>25OH Vitamin Dβ=β25-hydroxyvitamin D.</p><p>DBP β=β diastolic blood pressure.</p><p>FMD β=β flow-mediated dilation.</p><p>HDL β=β high density lipoprotein.</p><p>LDL β=β low density lipoprotein.</p><p>SBP β=β systolic blood pressure.</p