α,γ-Peptide nanotube templating of one-dimensional parallel fullerene arrangements

(Figure Presented) The formation and full characterization of single self-assembling α,γ-peptide nanotubes (α,γ-SPNs) is described. The introduction of C60 into cyclic peptides allows the preparation of supramolecular 1D fullerene arrangements induced by peptide nanotube formation under appropriate conditions. © 2009 American Chemical Society.This work was supported by the Spanish Ministry of Education and Science and the ERDF [SAF2007-61015 and Consolider Ingenio 2010 (CSD2007-00006)] and the Xunta de Galicia (GRC2006/ 132, PGIDIT06PXIB209018PR, PGIDIT08CSA047209PR, and R2006/ 124). The work by J.M.V. and J.L.C. was supported by Grants BFU2007- 62382/BMC from the Spanish MEC (J.M.V.) and S-0505/MAT/0283 from the Madrid Regional Government (J.M.V. and J.L.C.). C.R. and R.J.B. thank the Spanish MEC for their FPU Fellowships. We also thank Dr. Carmen Serra (Nanotechnology and Surface Analysis Service at C.A.C.T.I., University of Vigo) for her help with STM. We also thank Dowpharma for their kind gift of ENZA enzymes used in the preparation of D-Boc-γ-Acp-OH.Peer reviewe

Alfa, gamma-nanotubos peptídicos: diseño y síntesis

En los últimos años se han realizado grandes avances en el campo de la nanotecnología, el desarrollo de materiales nanométricos con novedosas propiedades ha sido el objetivo de muchos grupos de investigación.1 El Prof. Ghadiri y colaboradores descubrieron los nanotubos peptídicos formados mediante el autoensamblaje de D,L-α-ciclopéptidos, estos compuestos demostraron tener múltiples aplicaciones en los campos de la biotecnología, y la nanotecnología.2 En esta tesis doctoral se estudia una nueva familia de nanotubos peptídicos formados mediante el autoensamblaje molecular de α,γ- ciclopéptidos. Esto se realizó mediante varios proyectos diferentes: en el primero de ellos se estudió la capacidad de dimerización para ciclopéptidos en los que se alternaban γ-aminoácidos y α-aminoácidos-α,α-disustituidos. El segundo era demostrar la formación de nanotubos mediante el autoensamblaje molecular de los α,γ-ciclopéptidos, esta nueva familia de compuestos fue caracterizada mediante difracción de Rayos-X, FT-IR, TEM, AFM y STM

Chemometric modeling of organic contaminant sources in surface waters of a mediterranean river basin (Catalonia) district

Chemometric methods are applied to the analysis and interpretation of large multivariate data sets obtained in environmental monitoring studies. Concentrations of multiple organic compounds were measured in river samples taken from several sampling sites, at various geographical locations, during a number of campaigns and/or sampling time periods. Samples were collected and analyzed as part of an extensive multi-annual monitoring program from a mediterranean river basin (in Catalonia, at the northeast of Spain) by the Water Catalan Agency. Due to the great amount of multivariate data stored in environmental databases and to their complexity, chemometric modeling methods like Principal Components Analysis (PCA) and Multivariate Curve Resolution with Alternating Least-Squares (MCR-ALS) coupled to appropriate mapping representations are proposed for the evaluation of the environmental quality of the studied rivers. Results achieved in this study are intended to be a contribution to water quality assessment and evaluation of contamination of surface waters in Catalonia, and to support public policies of environmental control and management in the region under study.Fil: García Reiriz, Alejandro Gabriel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Analítica. Instituto de Química Rosario (IQUIR-CONICET); Argentina.Fil: Olivieri, Alejandro César. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Analítica. Instituto de Química Rosario (IQUIR-CONICET); Argentina.Fil: Teixidó, Elisabeth. Agència Catalana de l'Aigua; España.Fil: Ginebreda, Antoni. Instituto de Diagnóstico Ambiental y Estudios del Agua. Departamento de Química Ambiental (IDAEA-CSIC); España.Fil: Tauler, Romà. Instituto de Diagnóstico Ambiental y Estudios del Agua. Departamento de Química Ambiental (IDAEA-CSIC); España