Investigating Methyl And Nitro Substituents Affect In Para Position On N-Benzoyl-N'- Phenylthiourea Compounds As Potential Treatments For Breast Cancer

The primary challenge in chemotherapy for breast cancer stems from the limited effectiveness of existing drugs due to the diverse mutations, each requiring specific treatment. Consequently, it is essential to focus on the development of drugs specifically designed for anti-breast cancer therapy. In this investigation, we synthesized and evaluated compounds with methyl and nitro substituents on the para position in N-benzoyl- N'-phenylthiourea to examine their efficacy against breast cancer cells (MCF-7). Computational analyses demonstrated favorable interactions with EGFR, and experimental tests revealed IC50 values of 0.42 mM for the first compound and 0.07 mM for the second compound. Remarkably, the second molecule showed enhanced selectivity and cytotoxicity (SI value of 937.57) in comparison to the first compound, suggesting that it could be a promising drug for the treatment of breast cancer

The African hind's (Cephalopholis taeniops, serranidae) use of artificial reefs off Sal Island (Cape Verde): a preliminary study based on acoustic telemetry

The African hind Cephalopholis taeniops (Valenciennes, 1828) is one of the most important commercial demersal species caught in the Cape Verde archipelago. The species is closely associated with hard substrate and is one of the main attractions for SCUBA divers. In January 2006 a former Soviet fishing vessel - the Kwarcit - was sunk off Santa Maria Bay (Sal Island). Young C. taeniops are commonly observed in this artificial reef (AR). In order to investigate the species' use of the AR, 4 specimens were captured and surgically implanted underwater with Vemco brand acoustic transmitters. The fish were monitored daily with an active telemetry receiver for one week after release. Simultaneously, an array of 3 passive VR2 / VR2W receivers was set for 63 days, registering data that allowed an analysis of spatial, daily and short term temporal activity patterns. The results showed site fidelity to the AR, with no migrations to the nearby natural reef. The method used allowed to register a consistent higher activity during daytime and a preference for the area opposite the dominant current

New integrable extension of the Hubbard chain with variable range hopping

New integrable variant of the one-dimensional Hubbard model with variable-range correlated hopping is studied. The Hamiltonian is constructed by applying the quantum inverse scattering method on the infinite interval at zero density to the one-parameter deformation of the L-matrix of the Hubbard model. By construction, this model has Y(su(2))$\oplus$Y(su(2)) symmetry in the infinite chain limit. Multiparticle eigenstates of the model are investigated through this method.Comment: 25 pages, LaTeX, no figure

Contamination Control and Assay Results for the Majorana Demonstrator Ultra Clean Components

The MAJORANA DEMONSTRATOR is a neutrinoless double beta decay experiment utilizing enriched Ge-76 detectors in 2 separate modules inside of a common solid shield at the Sanford Underground Research Facility. The DEMONSTRATOR has utilized world leading assay sensitivities to develop clean materials and processes for producing ultra-pure copper and plastic components. This experiment is now operating, and initial data provide new insights into the success of cleaning and processing. Post production copper assays after the completion of Module 1 showed an increase in U and Th contamination in finished parts compared to starting bulk material. A revised cleaning method and additional round of surface contamination studies prior to Module 2 construction have provided evidence that more rigorous process control can reduce surface contamination. This article describes the assay results and discuss further studies to take advantage of assay capabilities for the purpose of maintaining ultra clean fabrication and process design.Comment: Proceedings of Low Radioactivity Techniques (LRT May 2017, Seoul