Current Performance and Future Strength of Political Science

The article and its five propositions question the current performance and future strength of political science as a discipline. Its empirics are based on the book series ‘The World of Political Science’, published between 2006 and 2012, on the development and current state of the various sub-disciplines, asking the question of ‘why we are where we are’ in political science. The topics discussed in the first section on the discipline’s actual strength are the relationship between the United States, Europe and the rest of the world, the advances and challenges of the discipline, and the issue of fragmentation and specialization. The second section addresses the relevance of political science to society and politics and the third the impact of current politics on the discipline. The text was presented at a preparatory conference in Helsinki in December 2013 and will be further discussed during a special round-table session at the International Political Science Association’s world congress in Montreal in July 2014. The propositions are intended to trigger debate among political scientists

What’s new? A first appraisal of the Juncker Commission

Although still in its early phases, the Juncker Commission has already broken new ground. Not only is Jean-Claude Juncker the first Commission President to be selected by the Spitzenkandidaten process, an extra-constitutional system that has reconfigured the European Union’s institutional balance, but he has transformed the structure and operation of the College in order to create a more political, and therefore more effective, Commission, and made good – so far – on his promise ‘to do better on the bigger things and be small on the small things’. This article examines this three-fold transformation. It looks at the innovations and change associated with the Juncker Commission. It considers what motivated them and how they were achieved, sets them in historical perspective, and discusses their implications for the institutions and for the EU more broadly

Strategi komunikasi rumah kreatif sleman dalam upaya pengembangan UMKM di era ekonomi digital

Penelitian ini membahas tentang strategi komunikasi Rumah Kreatif Sleman dalam upaya mengembangkan UMKM di Era ekonomi digital. Strategi meliputi komunikator, pesan, media, komunikan serta efek. Era revolusi industri 4.0. telah mendistraksi banyak hal salah satunya pola perdagangan konvensional menjadi online atau yang biasa disebut dengan ekonomi digital. Oleh karena itu Rumah Kreatif Sleman hadir sebagai wadah yang memfasilitasi dan membantu pengembangan UMKM di era ekonomi digital.Metode penelitian yang digunakan adalah metode penelitian kualitatif. Teori yang digunakan adalah teori Harold D. Laswell tentang strategi komunikasi yang mencakup lima komponen yakni komunikator, pesan, komunikan, media serta efek. Pengambilan data menggunakan teknik wawancara dan dokumentasi. Lokasi penelitian dilakukan di Rumah Kreatif Sleman, Roeby House, Lien’s Snack and Cookies dan Pawiro Chocolate.Hasil penelitian tersebut adalah komunikator dipilih melalui rapat bersama, sedangkan pesan disusun dengan tujuan menarik perhatian UMKM untuk bergabung serta memberi pemahaman. Komunikan ditentukan dari usaha yang berdiri di Sleman. Media yang digunakan terbagi menjadi dua yakni media eksternal dan internal. Capaian dari proses strategi komunikasi tersebut cukup positif, terbukti dengan selalu bertambahnya anggota UMKM yang bergabung. Selain itu UMKM mampu mengembangkan usahanya baik secara online maupun offline

Explaining variation in the effectiveness of transnational energy partnerships

This article analyzes the effectiveness of transnational multi-stakeholder partnerships for sustainable development-also known as "Type II outcomes" of the 2002 World Summit on Sustainable Development-in the sustainable energy sector. We combine quantitative and qualitative research. Quantitatively, we use a database of 340 partnerships, including 46 partnerships that focus on energy. Our qualitative analysis includes case studies of five partnerships that appear as the most effective and five that are operational but only with modest degrees of effectiveness. We study two competing hypotheses. The first, rooted in institutionalism, assumes that variation in effectiveness is related to organizational structures and procedures. The competing hypothesis emphasizes the power of actors and expects partnerships that involve key business actors and powerful Northern states to perform better. We conclude that the level of institutionalization is most important in explaining effectiveness, while powerful partners and the type of internal organization may further enhance effectiveness

De operatieve behandeling van de schuine onderbeensfractuur met behulp van de schuifplaat volgens Eggers

In hoofdstuk I wordt een historisch overzicht gegeven van de behandeling van onderbeensfracturen. Het blijkt dat de onstabiele schuine schachtfracturen steeds moeilijk te behandelen zijn geweest. Lang geleden heeft men al zijn heil in een operatieve behandeling gezocht. In hoofdstuk II wordt, na een korte bespreking van de chirurgische anatomie, de symptomatologie van de schachtfracturen van het onderbeen besproken. Het meest frequent is de schuine fractuur, die in het onderste derde deel van de schacht is gelocaliseerd. De symptomatologie van deze fractuur wordt eigenlijk geheel beheerst door de steeds weer optredende verkorting en door de verschuiving van de fractuurvlakken ten opzichte van elkaar. Ten gevolge van deze frequent voorkomende dislocatie is de schuine onderbeensfractuur, vooral wanneer tibia en fibula gelijktijdig gebroken zijn, een zo moeilijk te behandelen fractuur. De eindconclusie luidt: Primaire operatieve repositie en fixatie met een schuifplaat volgens Eggers (,,Internal contact splint" ) geeft bij schuine onderbeensfracturen de beste kansen op een goede en snelle genezing.... Zie: Conclusi

Design and synthesis of click lipids as tools to study immune cell metabolism

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids. Traditional lipid-tracking techniques using bulky fluorophores can distort natural uptake. To overcome this, the study introduces bioorthogonal chemical modifications, especially small cyclopropene groups, to label fatty acids (FAs), cholesterol, and triglycerides without disrupting their structure or function. The research outlines the synthesis of clickable monounsaturated and saturated FAs and demonstrates their uptake in various immune cells, including T cells, B cells, and macrophages. Furthermore, live-cell compatible analogues of monounsaturated, saturated, and polyunsaturated FAs were synthesized to study lipid uptake in a complex mixture of primary immune cells. They proved non-toxic, accurately mimicked natural lipids, and enabled precise single-cell analysis and revealed remarkable differences between different immune cell types. Clickable triglyceride-rich lipoprotein-like particles were synthesized and injected into mice, revealing lipid uptake dynamics in organs and immune cells at single-cell resolution. These tools provide insights into lipid metabolism under physiological conditions. Future work will explore lipid uptake mechanisms, essential FA metabolism, and signaling lipids, with implications for immunology and therapy. This study advances lipid tracking and functional analysis in immune cells.Bio-organic Synthesi