8,156 research outputs found
Are you serious? From fist bumping to hand hygiene: considering culture, context and complexity in infection prevention intervention research
Infection prevention is an under-resourced research and development topic, with limited evidence for practice in the most basic of measures. A survey of IPS R&D members indicated that what might appear to be simple interactions and interventions in healthcare, such as hand shaking and hand hygiene, should be considered complex interventions taking account of behaviour at the individual and social level as well as contextual factors. Future studies need to be designed utilising comprehensive approaches, for example, the Medical Research Council complex interventions framework, tailored to the country and more local cultural context, if we are to be serious about evidence for infection prevention and control practice
Variational formulas of higher order mean curvatures
In this paper, we establish the first variational formula and its
Euler-Lagrange equation for the total -th mean curvature functional
of a submanifold in a general Riemannian manifold
for . As an example, we prove that closed
complex submanifolds in complex projective spaces are critical points of the
functional , called relatively -minimal submanifolds,
for all . At last, we discuss the relations between relatively -minimal
submanifolds and austere submanifolds in real space forms, as well as a special
variational problem.Comment: 13 pages, to appear in SCIENCE CHINA Mathematics 201
Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada.
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia. We conducted a statistical analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) and the Canada Vigilance Adverse Reaction Database (CVARD) concerning the side effects of cholinesterase inhibitors. The statistics calculated for each adverse event were the frequency and the reporting odds ratios (ROR). A total of 9877 and 2247 reports were extracted from the FAERS and CVARD databases, respectively. A disproportionately higher frequency of reports of death as an adverse event for rivastigmine, compared to the other acetylcholinesterase inhibiting drugs, was observed in both the FAERS (ROR = 3.42; CI95% = 2.94-3.98; P<0.0001) and CVARD (ROR = 3.67; CI95% = 1.92-7.00; P = 0.001) databases. While cholinesterase inhibitors remain to be an important therapeutic tool against Alzheimer's disease, the disproportionate prevalence of fatal outcomes with rivastigmine compared with alternatives should be taken into consideration
The impact of inocula carryover and inoculum dilution on the methane yields in batch methane potential tests
Batch studies are used to benchmark biohydrogen potential (BHP) and biomethane potential (BMP) yields from feed substrates, digestates residues and different process configurations. This study shows that BMP yields using cellulose can be biased positively by not diluting the initial sewage sludge inoculum and the bias is independent of starting inoculum volatile solids (VS) concentration. The carryover of BHP inoculum also increased the BMP yields when using cellulose as a substrate by up to 18.8%. Furthermore it was also observed that the dilution of BMP inoculum with deionised H2O reduced methane yields from cellulose by up to 132 ± 26 N mL-CH4 g-VS−1. Therefore it is proposed that inoculum and standard substrate controls (as used in this study) should be included in methane batch methodologies, particularly when using a pre-fermentation stage such as dark fermentation
Radio-frequency operation of a double-island single-electron transistor
We present results on a double-island single-electron transistor (DISET)
operated at radio-frequency (rf) for fast and highly sensitive detection of
charge motion in the solid state. Using an intuitive definition for the charge
sensitivity, we compare a DISET to a conventional single-electron transistor
(SET). We find that a DISET can be more sensitive than a SET for identical,
minimum device resistances in the Coulomb blockade regime. This is of
particular importance for rf operation where ideal impedance matching to 50 Ohm
transmission lines is only possible for a limited range of device resistances.
We report a charge sensitivity of 5.6E-6 e/sqrt(Hz) for a rf-DISET, together
with a demonstration of single-shot detection of small (<=0.1e) charge signals
on microsecond timescales.Comment: 6 pages, 6 figure
Local origins impart conserved bone type-related differences in human osteoblast behaviour
Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; alkaline phosphatase (TNAP) mRNA and activity, Runt-related transcription factor-2 (RUNX2), SP7-transcription factor (SP7), bone sialoprotein-II (BSP-II), osteocalcin/bone gamma-carboxyglutamate (BGLAP), osteoprotegerin (OPG, TNFRSF11B), receptor activator of nuclear factor-κβ ligand (RANKL, TNFSF11) mRNA levels and proangiogenic vascular endothelial growth factor-A (VEGF-A) mRNA and protein release were assessed in osteoblasts from paired humeral head samples from age-matched, human OA/OP (n = 5/4) patients. Initial outgrowth and increase in cell number were significantly faster (p < 0.01) in subchondral and cortical than trabecular osteoblasts, in OA and OP, and this bone type-related differences were conserved despite consistently faster growth in OA. RUNX2/SP7 levels and TNAP mRNA and protein activity were, however, greater in trabecular than subchondral and cortical osteoblasts in OA and OP. BSP-II levels were significantly greater in trabecular and lowest in cortical osteoblasts in both OA and OP. In contrast, BGLAP levels showed divergent bone type-selective behaviour; highest in osteoblasts from subchondral origins in OA and trabecular origins in OP. We found virtually identical bone type-related differences, however, in TNFRSF11B:TNFSF11 in OA and OP, consistent with greater potential for paracrine effects on osteoclasts in trabecular osteoblasts. Subchondral osteoblasts (OA) exhibited highest VEGF-A mRNA levels and release. Our data indicate that human osteoblasts in trabecular, subchondral and cortical bone have inherent, programmed diversity, with specific bone type-related differences in growth, differentiation and pro-angiogenic potential in vitro
Observing sub-microsecond telegraph noise with the radio frequency single electron transistor
Telegraph noise, which originates from the switching of charge between
meta-stable trapping sites, becomes increasingly important as device sizes
approach the nano-scale. For charge-based quantum computing, this noise may
lead to decoherence and loss of read out fidelity. Here we use a radio
frequency single electron transistor (rf-SET) to probe the telegraph noise
present in a typical semiconductor-based quantum computer architecture. We
frequently observe micro-second telegraph noise, which is a strong function of
the local electrostatic potential defined by surface gate biases. We present a
method for studying telegraph noise using the rf-SET and show results for a
charge trap in which the capture and emission of a single electron is
controlled by the bias applied to a surface gate.Comment: Accepted for publication in Journal of Applied Physics. Comments
always welcome, email [email protected], [email protected]
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