The Project Management of Investigating Dowel Laminated Timber

During the Winter Quarter of 2020, three Architectural Engineering students investigated a new type of timber product, dowel laminated timber, for their senior project. Dowel laminated timber (DLT) is a specialty product typically associated with sustainable design and is a form of mass timber. The three students had little knowledge about mass timber outside of a timber design course; their knowledge was primarily in wood framing design. Therefore, the topic was chosen because dowel laminated timber is a topic that holds a large learning opportunity not only for the students but also for the profession. The purpose of the senior project was to investigate dowel laminated timber through fabricating specimens, analyze the performance of the specimens, and improve professional standards

What Happens in the Field Stays in the Field: Exploring Whether Professionals Play Minimax in Laboratory Experiments

The minimax argument represents game theory in its most elegant form: simple but with stark predictions. Although some of these predictions have been met with reasonable success in the field, experimental data have generally not provided results close to the theoretical predictions. In a striking study, Palacios-Huerta and Volij (2007) present evidence that potentially resolves this puzzle: both amateur and professional soccer players play nearly exact minimax strategies in laboratory experiments. In this paper, we establish important bounds on these results by examining the behavior of four distinct subject pools: college students, bridge professionals, world-class poker players, who have vast experience with high-stakes randomization in card games, and American professional soccer players. In contrast to Palacios-Huerta and Volij’s results, we find little evidence that real-world experience transfers to the lab in these games—indeed, similar to previous experimental results, all four subject pools provide choices that are generally not close to minimax predictions. We use two additional pieces of evidence to explore why professionals do not perform well in the lab: (1) complementary experimental treatments that pit professionals against preprogrammed computers, and (2) post-experiment questionnaires. The most likely explanation is that these professionals are unable to transfer their skills at randomization from the familiar context of the field to the unfamiliar context of the lab.

Are Subjects Making Financial Decisions in Lab Auctions or Are They Just Gambling?

Optimal bidding strategies in first-price and Dutch auctions are theoretically isomorphic but depend on bidder risk attitudes. However, laboratory experiments consistently find different behaviour between auction formats. This article explores whether the notion in psychology that financial and gambling risks are viewed differently can explain the discrepancy. Ultimately, the evidence does not support this hypothesis, but a bidder\u27s propensity to gamble is associated with how much risk he takes in both auctions whereas his propensity to take financial risks is not. The results suggest that subjects may view themselves as gambling in laboratory auctions rather than making financial decisions

Progress with the Prime Focus Spectrograph for the Subaru Telescope: a massively multiplexed optical and near-infrared fiber spectrograph

The Prime Focus Spectrograph (PFS) is an optical/near-infrared multi-fiber spectrograph with 2394 science fibers, which are distributed in 1.3 degree diameter field of view at Subaru 8.2-meter telescope. The simultaneous wide wavelength coverage from 0.38 μm to 1.26 μm, with the resolving power of 3000, strengthens its ability to target three main survey programs: cosmology, Galactic archaeology, and galaxy/AGN evolution. A medium resolution mode with resolving power of 5000 for 0.71 μm to 0.89 μm also will be available by simply exchanging dispersers. PFS takes the role for the spectroscopic part of the Subaru Measurement of Images and Redshifts (SuMIRe) project, while Hyper Suprime-Cam (HSC) works on the imaging part. HSC’s excellent image qualities have proven the high quality of the Wide Field Corrector (WFC), which PFS shares with HSC. The PFS collaboration has succeeded in the project Preliminary Design Review and is now in a phase of subsystem Critical Design Reviews and construction. To transform the telescope plus WFC focal ratio, a 3-mm thick broad-band coated microlens is glued to each fiber tip. The microlenses are molded glass, providing uniform lens dimensions and a variety of refractive-index selection. After successful production of mechanical and optical samples, mass production is now complete. Following careful investigations including Focal Ratio Degradation (FRD) measurements, a higher transmission fiber is selected for the longest part of cable system, while one with a better FRD performance is selected for the fiber-positioner and fiber-slit components, given the more frequent fiber movements and tightly curved structure. Each Fiber positioner consists of two stages of piezo-electric rotary motors. Its engineering model has been produced and tested. After evaluating the statistics of positioning accuracies, collision avoidance software, and interferences (if any) within/between electronics boards, mass production will commence. Fiber positioning will be performed iteratively by taking an image of artificially back-illuminated fibers with the Metrology camera located in the Cassegrain container. The camera is carefully designed so that fiber position measurements are unaffected by small amounts of high special-frequency inaccuracies in WFC lens surface shapes. Target light carried through the fiber system reaches one of four identical fast-Schmidt spectrograph modules, each with three arms. All optical glass blanks are now being polished. Prototype VPH gratings have been optically tested. CCD production is complete, with standard fully-depleted CCDs for red arms and more-challenging thinner fully-depleted CCDs with blue-optimized coating for blue arms. The active damping system against cooler vibration has been proven to work as predicted, and spectrographs have been designed to avoid small possible residual resonances

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis.

Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central signaling complex involved in inflammation and necroptosis. We show that RipK1 associates with RipK3 in an early necrosome, independent of RipK3 phosphorylation and MLKL-induced necroptotic death. We find that formation of the early necrosome activates K48-ubiquitin-dependent proteasomal degradation of RipK1, Caspase-8, and other necrosomal proteins. Our results reveal that the E3-ubiquitin ligase Triad3a promotes this negative feedback loop independently of typical RipK1 ubiquitin editing enzymes, cIAPs, A20, or CYLD. Finally, we show that Triad3a-dependent necrosomal degradation limits necroptosis and production of inflammatory cytokines. These results reveal a new mechanism of shutting off necrosome signaling and may pave the way to new strategies for therapeutic manipulation of inflammatory responses

Rationality, Irrationality and Escalating Behavior in Lowest Unique Bid Auctions

Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions – lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of “bid space”. The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets

Candidate Electromagnetic Counterpart to the Binary Black Hole Merger Gravitational Wave Event S190521g

We report the first plausible optical electromagnetic (EM) counterpart to a (candidate) binary black hole (BBH) merger. Detected by the Zwicky Transient Facility (ZTF), the EM flare is consistent with expectations for a kicked BBH merger in the accretion disk of an active galactic nucleus (AGN), and is unlikely ($<O(0.01\%$)) due to intrinsic variability of this source. The lack of color evolution implies that it is not a supernovae and instead is strongly suggestive of a constant temperature shock. Other false-positive events, such as microlensing or a tidal disruption event, are ruled out or constrained to be $<O(0.1\%$). If the flare is associated with S190521g, we find plausible values of: total mass $M_{\rm BBH} \sim 100 M_{\odot}$, kick velocity $v_k \sim 200\, {\rm km}\, {\rm s}^{-1}$ at $\theta \sim 60^{\circ}$ in a disk with aspect ratio $H/a \sim 0.01$ (i.e., disk height $H$ at radius $a$) and gas density $\rho \sim 10^{-10}\, {\rm g}\, {\rm cm}^{-3}$. The merger could have occurred at a disk migration trap ($a \sim 700\, r_{g}$; $r_g \equiv G M_{\rm SMBH} / c^2$, where $M_{\rm SMBH}$ is the mass of the AGN supermassive black hole). The combination of parameters implies a significant spin for at least one of the black holes in S190521g. The timing of our spectroscopy prevents useful constraints on broad-line asymmetry due to an off-center flare. We predict a repeat flare in this source due to a re-encountering with the disk in $\sim 1.6\, {\rm yr}\, (M_{\rm SMBH}/10^{8}M_{\odot})\, (a/10^{3}r_{g})^{3/2}$.Comment: 9 pages, 4 figures, accepted for publication in Physical Review Letters (June 25, 2020

Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection

CD8+ T cells lacking CXCR3 and CCR5 expression have impaired contraction and generate an increased number of memory cells after virus infection