Central Diffraction in Proton-Proton Collisions at s=7\sqrt{s}=7\,TeV with ALICE at LHC

A double-gap topology is used for filtering central-diffractive events from a proton-proton minimum-bias data sample at a centre-of-mass energy {$\sqrt{s}=7$\,TeV}. This topology is defined by particle activity in the ALICE central barrel and absence of particle activity outside. The fraction of events satisfying the double-gap requirement $R_{DG}$ is found to be {$7.63\pm0.02(stat.)\pm0.87(syst.)\times 10^{-4}$}. The background of this double-gap fraction is estimated by studying the contributions of non-diffractive, single- and double-diffractive dissociation processes as modelled by Monte Carlo event generators, and is found to be about 10%.Comment: 4 pages, 2 figures, Proceedings Diffraction 2012 - International Workshop on Diffraction in High-Energy Physics, Puerto del Carmen, Sept. 10-15, 201

Upgrade of the ALICE Inner Tracking System

During the Long Shutdown 2 of the LHC in 2018/2019, the ALICE experiment plans the installation of a novel Inner Tracking System. It will replace the current six layer detector system with a seven layer detector using Monolithic Active Pixel Sensors. The upgraded Inner Tracking System will have significantly improved tracking and vertexing capabilities, as well as readout rate to cope with the expected increased Pb-Pb luminosity of the LHC. The choice of Monolithic Active Pixel Sensors has been driven by the specific requirements of ALICE as a heavy ion experiment dealing with rare processes at low transverse momenta. This leads to stringent requirements on the material budget of 0.3$$ per layer for the three innermost layers. Furthermore, the detector will see large hit densities of $\sim 19 \mathrm{cm}^{-2}/\mathrm{event}$ on average for minimum-bias events in the inner most layer and has to stand moderate radiation loads of 700 kRad TID and $1\times 10^{13}$ 1 MeV n$_\mathrm{eq}/\mathrm{cm}^{2}$ NIEL at maximum. The Monolithic Active Pixel Sensor detectors are manufactured using the TowerJazz 0.18 $\mu$m CMOS Imaging Sensor process on wafers with a high-resistivity epitaxial layer. This contribution summarises the recent R&D activities and focuses on results on the large-scale pixel sensor prototypes.Comment: 10 pages, 8 figures, proceedings of VERTEX 2014, 15-19 September 201

Data Collection in Maine: Assessing the Return on Public Investment in Maine’s Early Childhood System

To better understand the outcomes of investments in early childhood, we need comprehensive data to measure benchmarks, according to Judy Reidt-Parker. She describes the current state of data collec­tion in Maine and discusses data that are needed and where there are opportunities for improvement. The greatest need is for the development of a common set of child and program outcomes that can be shared across departments and systems and for linking systems so that children’s progress can be followed longitudinall

The Importance of Continuity of Care: Policies and Practices in Early Childhood Systems and Programs

Continuity of care — strategies designed to lengthen children's ability to continuously participate in high-quality early learning experiences — must be a cornerstone or guiding principle for state or local early childhood policy agendas focused on improving outcomes for less-advantaged children and families. This paper provides a research summary, considerations for program and policy design, best practices, case studies and talking points that advocates can use to help policymakers and early childhood practitioners implement continuity-of-care policies and practices

Child Care, Money and Maine: Implications for Federal and State Policy

Child Care, Money and Maine was chosen as the title for this document because, as we enter into the new century, child day care services have become an essential component to a healthy economy in Maine and in the nation. The availability of good child care has a major impact on a family’s ability to find, train for, and sustain employment. Child care is also crucial to modern businesses being able to recruit, retain and sustain employees. Lack of dependable and appropriate child care will be a critical barrier to the movement of low-income families from welfare to work. The quality of the care being provided has a profound effect on the lives of our children, which in turn has major implications for state education, social services, juvenile justice and Medicaid budgets.https://digitalcommons.usm.maine.edu/facbooks/1093/thumbnail.jp

Studies for the ALICE Inner Tracking System Upgrade

The ALICE experiment at the CERN LHC identifies D0 mesons via secondary-vertex reconstruction and topological cuts to reduce the corresponding combinatorial background in heavy-ion collisions. The D0 meson is produced promptly in initial, hard scatterings via the strong interaction or as feed-down from weakly decaying B hadrons. Within this thesis, a novel method for the separation of prompt and feed-down D0 mesons using cut variations was implemented and applied to data from p–Pb collisions at sqrt(s_NN) = 5.02 TeV. The effectiveness of the secondary-vertex reconstruction strongly depends on the performance and in particular the pointing resolution of the Inner Tracking System. The upgrade of the ALICE Inner Tracking System for the Long Shutdown 2 of the LHC in 2019/2020 will significantly improve its vertex-reconstruction and tracking capabilities. It will be equipped with Monolithic Active Pixel Sensors manufactured using the TowerJazz 180nm CMOS process on wafers with a high-resistivity epitaxial layer. In another part of this thesis, several pixel-chip prototypes of the ALPIDE architecture with in-pixel amplification and discrimination as well as in-matrix data reduction were characterised. The pALPIDE-2 prototype was measured to fulfil the requirements in terms of detection efficiency, fake-hit rate, position resolution and tolerance to irradiation with non-ionising energy loss. Based on simulations modelling the tracking and vertex-reconstruction performance of the upgraded Inner Tracking System, the perspective of the feed-down separation using cut variations after the upgrade was assessed within this thesis

Efficient, Reliable and Secure Distributed Protocols for MANETs

This thesis is divided into two parts. The first part explores the difficulties of bootstrapping and maintaining a security infrastructure for military Mobile Ad Hoc NETworks (MANETs). The assumed absence of dedicated infrastructural elements necessitates, that security services in ad hoc networks may be built from the ground up. We develop a cluster algorithm, incorporating a trust metric in the cluster head selection process to securely determine constituting nodes in a distributed Trust Authority (TA) for MANETs. Following this, we develop non-interactive key distribution protocols for the distribution of symmetric keys in MANETs. We explore the computational requirements of our protocols and simulate the key distribution process. The second part of this thesis builds upon the security infrastructure of the first part and examines two distributed protocols for MANETs. Firstly, we present a novel algorithm for enhancing the efficiency and robustness of distributed protocols for contacting TA nodes in MANETs. Our algorithm determines a quorum of trust authority nodes required for a distributed protocol run based upon a set of quality metrics, and establishes an efficient routing strategy to contact these nodes. Secondly, we present a probabilistic path authentication scheme based on message authentication codes (MACs). Our scheme minimises both communication and computation overhead in authenticating the path over which a stream of packets travels and facilitates the detection of adversarial nodes on the path

A homologue of the breast cancer associated gene BARD1 is involved in DNA repair in plants

hBRCA1 and hBARD1 are tumor suppressor proteins that are involved as heterodimer via ubiquitinylation in many cellular processes, such as DNA repair. Loss of BRCA1 or BARD1 results in early embryonic lethality and chromosomal instability. The Arabidopsis genome carries a BRCA1 homologue, and we were able to identify a BARD1 homologue. AtBRCA1 and the putative AtBARD1 protein are able to interact with each other as indicated by in vitro and in planta experiments. We have identified T-DNA insertion mutants for both genes, which show no visible phenotype under standard growth conditions and are fully fertile. Thus, in contrast to animals, both genes have no indispensable role during development and meiosis in plants. The two single as well as the double mutant are to a similar extent sensitive to mitomycin C, indicating an epistatic interaction in DNA crosslink repair. We could further demonstrate that in Arabidopsis BARD1 plays a prominent role in the regulation of homologous DNA repair in somatic cells

BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana

BRCA1 is a well-known tumor suppressor protein in mammals, involved in multiple cellular processes such as DNA repair, chromosome segregation and chromatin remodeling. Interestingly, homologs of BRCA1 and several of its complex partners are also found in plants. As the respective mutants are viable, in contrast to mammalian mutants, detailed analyses of their biological role is possible. Here we demonstrate that the model plant Arabidopsis thaliana harbors two homologs of the mammalian BRCA1 interaction partner BRCC36, AtBRCC36A and AtBRCC36B. Mutants of both genes as well as the double mutants are fully fertile and show no defects in development. We were able to show that mutation of one of the homologs, AtBRCC36A, leads to a severe defect in intra- and interchromosomal homologous recombination (HR). A HR defect is also apparent in Atbrca1 mutants. As the Atbrcc36a/Atbrca1 double mutant behaves like the single mutants of AtBRCA1 and AtBRCC36A both proteins seem to be involved in a common pathway in the regulation of HR. AtBRCC36 is also epistatic to AtBRCA1 in DNA crosslink repair. Upon genotoxic stress, AtBRCC36A is transferred into the nucleus