Foundations of Trusted Autonomy

This book establishes the foundations needed to realize the ultimate goals for artificial intelligence, such as autonomy and trustworthiness. Aimed at scientists, researchers, technologists, practitioners, and students, it brings together contributions offering the basics, the challenges and the state-of-the-art on trusted autonomous systems in a single volume. The book is structured in three parts, with chapters written by eminent researchers and outstanding practitioners and users in the field. The first part covers foundational artificial intelligence technologies, while the second part covers philosophical, practical and technological perspectives on trust. Lastly, the third part presents advanced topics necessary to create future trusted autonomous systems. The book augments theory with real-world applications including cyber security, defence and space

Contextually aware intelligent control agents for heterogeneous swarms

An emerging challenge in swarm shepherding research is to design effective and efficient artificial intelligence algorithms that maintain simplicity in their decision models, whilst increasing the swarm’s abilities to operate in diverse contexts. We propose a methodology to design a context-aware swarm control intelligent agent (shepherd). We first use swarm metrics to recognise the type of swarm that the shepherd interacts with, then select a suitable parameterisation from its behavioural library for that particular swarm type. The design principle of our methodology is to increase the situation awareness (i.e. contents) of the control agent without sacrificing the low computational cost necessary for efficient swarm control. We demonstrate successful shepherding in both homogeneous and heterogeneous swarms.</p

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Approved for public release

New genetic operators are described that assure preservation of the feasibility of candidate solutions to any discrete and linearly constrained optimisation problem. The design of these operators is the result of extensive theoretical investigations, with particular assiduity devoted to considering the most challenging examples of this type. Attention is largely centred on problems that have defied satisfactory solution by traditional means, because of poorly behaved or imprecise objective functions, high dimensionality, or intractable algorithmic complexity. Evolutionary Algorithms, inspired by adaptation in biological systems, are ideally suited to such arduous conditions, as testified by their increasing popularity and successful exploitation in resolving numerous difficult problems. Their obvious attraction notwithstanding, the applicability of evolutionary algorithms has suffered by the deficiency of general techniques to manage constraints, a feature common to many problems, and the asperity is compounded when some proportion of the decision variables are discrete. The enhanced operators presented here guarantee the feasibility of proffered aspirant solutions with respect to a system of linear constraints. Exploration of highly constrained systems indicates the possibility of performance degradation, with the diminishing probability of discovering a feasible and meaningful exchange of information between candidate solutions. Relaxation of the crossover operator is proposed to alleviate this, and the effective utilisation of this in the context of the overall algorithm suggests a modification in which the population is permitted to transiently increase in size