Die Rolle der Körperlichkeit im gegenwärtigen Personbegriff

Der Begriff der Person dient in der Neuzeit im wesentlichen der Explikation des menschlichen Selbstverständnisses (Sturma 1997). In der gegenwärtigen Philosophie wird der Begriff der Person vor allem in zwei Problemzusammenhängen thematisiert: in praktischen Kontexten wie Ethik, Handlungstheorie und Rechtsphilosophie und in metaphysisch-ontologischen Theorien zur Frage des Zusammenhangs von Körper und Geist (Herrmann 2001, Quante 1999)

Essays in time series econometrics

This cumulative dissertation consists of three self-contained papers all contributing to the cointegrating regression literature. The first chapter is devoted to classical linear cointegrating regressions, i.e., regressions that contain integrated processes as regressors. It combines traditional and self-normalized Wald-type test statistics with a vector autoregressive sieve bootstrap to reduce size distortions of hypothesis tests on the cointegrating vector. The second chapter focuses on panels of cointegrating polynomial regressions, i.e., panels of regressions that include an integrated process and its powers as regressors. It derives the asymptotic properties of a group-mean fully modified OLS estimator and hypothesis tests based upon it in a fixed cross-section and large time series dimension. The third chapter is devoted to testing for a cointegrating relationship between a fixed number of integrated processes. In particular, it derives asymptotic theory for an existing nonparametric variance ratio unit root test (originally proposed to test for an unit root in an observed univariate time series) when applied to regression residuals

Accurate and (almost) tuning parameter free inference in cointegrating regressions

Tuning parameter choices complicate statistical inference in cointegrating regressions and affect finite sample distributions of test statistics. As commonly used asymptotic theory fails to capture these effects, tests often suffer from severe size distortions. We propose a novel self-normalized test statistic for general linear hypotheses, which avoids the choice of tuning parameters. Its limiting null distributions is nonstandard, but simulating asymptotically valid critical values is straightforward. To further improve the performance of the test in small to medium samples, we employ the vector autoregressive sieve bootstrap to construct critical values. To show its consistency, we establish a bootstrap invariance principle result under conditions that go beyond the assumptions commonly imposed in the literature. Simulation results demonstrate that our new test outperforms competing approaches, as it has good power properties and is considerably less prone to size distortions

Entgeltflexibilisierung aus juristischer Sicht : juristische Beiträge des interdisziplinären Symposiums "Flexibilisierung des Arbeitsentgelts aus ökonomischer und juristischer Sicht" am 25. und 26. Januar 2001 in Mannheim

Juristische Beiträge des interdisziplinären Symposiums "Flexibilisierung des Arbeitsentgelts aus ökonomischer und juristischer Sicht" am 25. und 26.Januar 2001 in Mannheim

Entgeltflexibilisierung aus juristischer Sicht: Juristische Beiträge des interdiziplinären Symposiums Flexibilisierung des Arbeitsentgelts aus Ökonomischer und Juristischer Sicht am 25. und 26. Januar 2001 in Mannheim

--

Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM

The mitochondria of the proximal tubule are essential for providing energy in this nephron segment, whose ATP generation is almost exclusively oxygen dependent. In addition, mitochondria are involved in a variety of metabolic processes and complex signaling networks. Proximal tubular mitochondrial dysfunction can therefore affect renal function in very different ways. Two autosomal dominantly inherited forms of renal Fanconi syndrome illustrate how multifaceted mitochondrial pathology can be: Mutation of EHHADH, an enzyme in fatty acid metabolism, results in decreased ATP synthesis and a consecutive transport defect. In contrast, mutations of GATM, an enzyme in the creatine biosynthetic pathway, leave ATP synthesis unaffected but do lead to mitochondrial protein aggregates, inflammasome activation, and renal fibrosis with progressive renal failure. In this review article, the distinct pathophysiological mechanisms of these two diseases are presented, which are examples of the spectrum of proximal tubular mitochondrial diseases