Estimating sunspot number

An empirical method is developed to predict certain parameters of future solar activity cycles. Sunspot cycle statistics are examined, and curve fitting and linear regression analysis techniques are utilized

The Effective Potential of the N=0* Yang-Mills Theory

We study the \N=4 SYM theory with SU(N) gauge group in the large N limit, deformed by giving equal mass to the four adjoint fermions. With this modification, a potential is dynamically generated for the six scalars in the theory, \phi^i. We show that the resulting theory is stable (perturbatively in the 't Hooft coupling), and that there are some indications that =0 is the vacuum of the theory. Using the AdS/CFT correspondence, we compare the results to the corresponding supergravity computation, i.e. brane probing a deformed AdS_5 x S^5 background, and we find qualitative agreement.Comment: 12 pages, 2 figures, version to appear in JHE

Film calibration for the Skylab/ATM S-056 X-ray telescope

The sensitometry and film calibration effort for the Skylab/ATM S-056 X-ray telescope is summarized. The apparatus and procedures used are described together with the two types of flight film used, Kodak SO-212 and SO-242. The sensitometry and processing of the flight film are discussed, and the results are presented in the form of the characteristic curves and related data. The use of copy films is also discussed

Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries

The first bioengineered, autologous, dermo-epidermal skin grafts are presently undergoing clinical trials; hence, it is reasonable to envisage the next clinical step at the forefront of plastic and burn surgery, which is the generation of autologous skin grafts that contain vascular plexuses, preformed in vitro. As the importance of the blood, and particularly the lymphatic vascular system, is increasingly recognized, it is attractive to engineer both human blood and lymphatic vessels in one tissue or organ graft. We show here that functional lymphatic capillaries can be generated using three-dimensional hydrogels. Like normal lymphatics, these capillaries branch, form lumen, and take up fluid in vitro and in vivo after transplantation onto immunocompromised rodents. Formation of lymphatic capillaries could be modulated by both lymphangiogenic and anti-lymphangiogenic stimuli, demonstrating the potential usefulness of this system for in vitro testing. Blood and lymphatic endothelial cells never intermixed during vessel development, nor did blood and lymphatic capillaries anastomose under the described circumstances. After transplantation of the engineered grafts, the human lymphatic capillaries anastomosed to the nude rat's lymphatic plexus and supported fluid drainage. Successful preclinical results suggest that these skin grafts could be applied on patients suffering from severe skin defects

Impact of carbon dioxide versus air pneumoperitoneum on peritoneal cell migration and cell fate

Background: Postoperative systemic immune function is suppressed after open abdominal surgery, as compared with that after minimally invasive abdominal surgery. As a first line of defense, peritoneal macrophages (PMo) and polymorphonuclear neutrophil granulocytes (PMNs) are of primary importance in protecting the body from microorganisms. Previous studies have shown changes in these cell populations over time after open versus laparoscopic surgery. This study aimed to investigate the dynamics of cell recruitment and clearance of peritoneal cells. Methods: Female NMRI mice (33 ± 2 g) were randomly assigned to carbon dioxide (CO2) or air insufflation. Intravasal cells with phagocytic capabilities were selectively stained by intravenous injection of the fluorescent dye PKH26 24 h before surgery. Gas was insufflated into the peritoneal cavity through a catheter, and the pneumoperitoneum was maintained for 30 min. Peritoneal lavage was performed 1, 3, 8, or 24 h after surgery. Apoptotic cells were assessed by flow cytometry using a general caspase substrate. Results: The total peritoneal cell count did not differ between groups. The PKH26-positive PMo level was significantly increased after CO2, as compared with air, at 1 h and 24 h. The ratio of apoptotic PMo did not differ between the groups. In the peritoneal lavage, polymorphonuclear leukocytes (PMNs) were tripled in the air group, as compared with the CO2 group, whereas the ratio of apoptotic PMNs was significantly decreased. There was a higher fraction of PKH26-positive PMNs after air exposure, as compared with that after CO2. Conclusions: Air exposure triggered a higher transmigration rate of PMNs from the blood compartment into the peritoneal cavity and decreased PMN apoptosis, as compared with CO2. The lower proportion of PKH26-positive peritoneal macrophages in the air group might have been attributable to a higher inflammatory stimulation than in the CO2 group, leading to increased emigration of PMo to draining lymph nodes. All the findings underscore a complex cell-specific regulation of cell recruitment and clearance in the peritoneal compartmen

Proteasome Lid Bridges Mitochondrial Stress with Cdc53/Cullin1 NEDDylation Status

Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle progression, development, and survival. Cul1 rubylation is balanced by the COP9 signalosome (CSN), a multi-subunit derubylase that shows 1:1 paralogy to the 26 S proteasome lid. The turnover of SCF substrates and their relevance to various diseases is well studied, yet, the extent by which environmental perturbations influence Cul1 rubylation/derubylation cycles per se is still unclear. In this study, we show that the level of cellular oxidation serves as a molecular switch, determining Cullin1 rubylation/derubylation ratio. We describe a mutant of the proteasome lid subunit, Rpn11 that exhibits accumulated levels of Cullin1-Rub1 conjugates, a characteristic phenotype of csn mutants. By dissecting between distinct phenotypes of rpn11 mutants, proteasome and mitochondria dysfunction, we were able to recognize the high reactive oxygen species (ROS) production during the transition of cells into mitochondrial respiration, as a checkpoint of Cullin1 rubylation in a reversible manner. Thus, the study adds the rubylation cascade to the list of cellular pathways regulated by redox homeostasis

A Fermi Surface Model for Large Supersymmetric AdS_5 Black Holes

We identify a large family of 1/16 BPS operators in N=4 SYM that qualitatively reproduce the relations between charge, angular momentum and entropy in regular supersymmetric AdS_5 black holes when the main contribution to their masses is given by their angular momentum.Comment: 32 pages, 6 figures, LaTeX uses JHEP3 class; ver 2- added acknowledgment, minor change

Observation of the impulsive phase of a simple flare

We present a broad range of complementary observations of the onset and impulsive phase of a fairly large (1B, M1.2) but simple two-ribbon flare. The observations consist of hard X-ray flux measured by the SMM HXRBS, high-sensitivity measurements of microwave flux at 22 GHz from Itapetinga Radio Observatory, sequences of spectroheliograms in UV emission lines from Ov (T ≈ 2 × 10⁵ K) and FeXXI (T ≈ 1 × 10⁷ K) from the SMM UVSP, Hα and HeI D₃ cine-filtergrams from Big Bear Solar Observatory, and a magnetogram of the flare region from the MSFC Solar Observatory. From these data we conclude: (1) The overall magnetic field configuration in which the flare occurred was a fairly simple, closed arch containing nonpotential substructure. (2) The flare occurred spontaneously within the arch; it was not triggered by emerging magnetic flux. (3) The impulsive energy release occurred in two major spikes. The second spike took place within the flare arch heated in the first spike, but was concentrated on a different subset of field lines. The ratio of Ov emission to hard X-ray emission decreased by at least a factor of 2 from the first spike to the second, probably because the plasma density in the flare arch had increased by chromospheric evaporation. (4) The impulsive energy release most likely occurred in the upper part of the arch; it had three immediate products: (a) An increase in the plasma pressure throughout the flare arch of at least a factor of 10. This is required because the FeXXI emission was confined to the feet of the flare arch for at least the first minute of the impulsive phase. (b) Nonthermal energetic (∼ 25 keV) electrons which impacted the feet of the arch to produce the hard X-ray burst and impulsive brightening in Ov and D₃. The evidence for this is the simultaneity, within ± 2 s, of the peak Ov and hard X-ray emissions. (c) Another population of high-energy (∼100keV) electrons (decoupled from the population that produced the hard X-rays) that produced the impulsive microwave emission at 22 GHz. This conclusion is drawn because the microwave peak was 6 ± 3 s later than the hard X-ray peak