Subcooled boiling in a negligible gravity field final report

Forces acting on bubble formed in nucleate boiling and effect of gravity on removal of vapor bubble from heated surfac

Improving Mechanical Ventilator Clinical Decision Support Systems with A Machine Learning Classifier for Determining Ventilator Mode

Clinical decision support systems (CDSS) will play an in-creasing role in improving the quality of medical care for critically ill patients. However, due to limitations in current informatics infrastructure, CDSS do not always have com-plete information on state of supporting physiologic monitor-ing devices, which can limit the input data available to CDSS. This is especially true in the use case of mechanical ventilation (MV), where current CDSS have no knowledge of critical ventilation settings, such as ventilation mode. To enable MV CDSS to make accurate recommendations related to ventilator mode, we developed a highly performant ma-chine learning model that is able to perform per-breath clas-sification of 5 of the most widely used ventilation modes in the USA with an average F1-score of 97.52%. We also show how our approach makes methodologic improvements over previous work and that it is highly robust to missing data caused by software/sensor error

Beam heat load analysis with COLDDIAG: a cold vacuum chamber for diagnostics

The knowledge of the heat intake from the electron beam is essential to design the cryogenic layout of superconducting insertion devices. With the aim of measuring the beam heat load to a cold bore and understanding the responsible mechanisms, a cold vacuum chamber for diagnostics (COLDDIAG) has been built. The instrumentation comprises temperature sensors, pressure gauges, mass spectrometers and retarding field analyzers, which allow to study the beam heat load and the influence of the cryosorbed gas layer. COLDDIAG was installed in the storage ring of the Diamond Light Source from September 2012 to August 2013. During this time measurements were performed for a wide range of machine conditions, employing the various measuring capabilities of the device. Here we report on the analysis of the measured beam heat load, pressure and gas content, as well as the low energy charged particle flux and spectrum as a function of the electron beam parameters

Linear approaches to intramolecular Förster Resonance Energy Transfer probe measurements for quantitative modeling

Numerous unimolecular, genetically-encoded Forster Resonance Energy Transfer (FRET) probes for monitoring biochemical activities in live cells have been developed over the past decade. As these probes allow for collection of high frequency, spatially resolved data on signaling events in live cells and tissues, they are an attractive technology for obtaining data to develop quantitative, mathematical models of spatiotemporal signaling dynamics. However, to be useful for such purposes the observed FRET from such probes should be related to a biological quantity of interest through a defined mathematical relationship, which is straightforward when this relationship is linear, and can be difficult otherwise. First, we show that only in rare circumstances is the observed FRET linearly proportional to a biochemical activity. Therefore in most cases FRET measurements should only be compared either to explicitly modeled probes or to concentrations of products of the biochemical activity, but not to activities themselves. Importantly, we find that FRET measured by standard intensity-based, ratiometric methods is inherently non-linear with respect to the fraction of probes undergoing FRET. Alternatively, we find that quantifying FRET either via (1) fluorescence lifetime imaging (FLIM) or (2) ratiometric methods where the donor emission intensity is divided by the directly-excited acceptor emission intensity (denoted R<sub>alt</sub>) is linear with respect to the fraction of probes undergoing FRET. This linearity property allows one to calculate the fraction of active probes based on the FRET measurement. Thus, our results suggest that either FLIM or ratiometric methods based on R<sub>alt</sub> are the preferred techniques for obtaining quantitative data from FRET probe experiments for mathematical modeling purpose

Combining best evidence: A novel method to calculate the alcohol-attributable fraction and its variance for injury mortality

<p>Abstract</p> <p>Background</p> <p>The alcohol-attributable fraction for injury mortality is defined as the proportion of fatal injury that would disappear if consumption went to zero. Estimating this fraction has previously been based on a simplistic view of drinking and associated risk. This paper develops a new way to calculate the alcohol-attributable fraction for injury based on different dimensions of drinking, mortality data, experimental data, survey research, new risk scenarios, and by incorporating different distributions of consumption within populations. For this analysis, the Canadian population in 2005 was used as the reference population.</p> <p>Methods</p> <p>Binge drinking and average daily consumption were modeled separately with respect to the calculation of the AAF. The acute consumption risk was calculated with a probability-based method that accounted for both the number of binge drinking occasions and the amount of alcohol consumed per occasion. The average daily consumption was computed based on the prevalence of daily drinking at various levels. These were both combined to get an overall estimate. 3 sensitivity analyses were performed using different alcohol consumption parameters to test the robustness of the model. Calculation of the variance to generate confidence limits around the point estimates was accomplished via Monte Carlo resampling methods on randomly generated AAFs that were based on the distribution and prevalence of drinking in the Canadian population.</p> <p>Results</p> <p>Overall, the AAFs decrease with age and are significantly lower for women than men across all ages. As binge drinking increases, the injury mortality AAF also increases. Motor vehicle collisions show the largest relative increases in AAF as alcohol consumption is increased, with over a 100% increase in AAF from the lowest to highest consumption category. Among non-motor vehicle collisions, the largest change in total AAF occurred both for homicide and other intentional injuries at about a 15% increase in the AAF from the lowest to the highest binge consumption scenarios.</p> <p>Conclusions</p> <p>This method combines the best available evidence to generate new alcohol-attributable fractions for alcohol-attributable injury mortality. Future research is needed to refine the risk function for non-motor vehicle injury types and to investigate potential interactions between binge drinking and average volume of alcohol consumption.</p

Management von Obstipation im palliativen Setting : Vorschläge für die Umsetzung durch das interprofessionelle Team

Einleitung: Die Palliative Care hat sich zu einem umfassenden Ansatz für die Behandlung von komplexen Symptomen im Spektrum lebenslimitierender Krankheiten entwickelt. Obwohl Obstipation ein häufiges Symptom bei Palliativ-Patient:innen darstellt, scheint bei Health Professionals ein mangelndes Bewusstsein für das Management von Obstipation vorzuliegen. Das Management der Obstipation ist ein multimodaler Ansatz, welcher deren Prävention sowie Behandlung durch Medikation, Flüssigkeits- und Nahrungsaufnahme, Mobilität und Behandlung von obstipationsbedingtem Schmerz beinhaltet (siehe Abb. 1).1 Ziel dieses Managements ist die Wiederherstellung einer aus Patient:innen-Sicht angenehmen Stuhlgewohnheit und die Linderung von Schmerzen, die im Zusammenhang mit Obstipation auftreten können. Fragestellung: Wie kann das interprofessionelle Team das Management von Obstipation im palliativen Setting unterstützen? Methode: In den Datenbanken PubMed und CINAHL Complete wurde eine systematisierte Literaturrecherche durchgeführt. Fünf Studien wurden eingeschlossen. Ergebnisse: Obstipation im palliativen Setting ist aufgrund der veränderten Lebensverhältnisse als ein Langzeitsymptom zu betrachten. Es werden die Interventionen Darm-Massage, Bewegung / Ballaststoffe / Flüssigkeit sowie medikamentöse Interventionen vorgestellt (siehe Tab. 1). Diskussion: Die Interventions-Wahl kann durch fehlende vorherige Durchführung eines geeigneten Assessments sowie Fachwissens-Lücken erschwert sein. Health Professionals sollen Obstipation als interprofessionelle Thematik angehen, wobei auch nicht-medikamentöse Interventionen zum Einsatz kommen sollen. Bedürfnisse und Gewohnheiten der Betroffenen müssen im Management berücksichtigt werden. Schlussfolgerung: Das Symptom Obstipation soll im palliativen Setting im Fokus der Aufmerksamkeit des ganzen interprofessionellen Teams stehen

Influence of nuclear structure on sub-barrier hindrance in Ni+Ni fusion

Fusion-evaporation cross sections for $^{64}$Ni+$^{64}$Ni have been measured down to the 10 nb level. For fusion between two open-shell nuclei, this is the first observation of a maximum in the $S$-factor, which signals a strong sub-barrier hindrance. A comparison with the $^{58}$Ni+$^{58}$Ni, $^{58}$Ni+$^{60}$Ni, and $^{58}$Ni+$^{64}$Ni systems indicates a strong dependence of the energy where the hindrance occurs on the stiffness of the interacting nuclei.Comment: Submitted to Phys. Rev. Lett. 4 pages, 3 figure

ENERGY MEASUREMENTS WITH RESONANT SPIN DEPOLARISATION AT DIAMOND

Abstract A precise knowledge of the electron beam energy is critical for the accurate determination of many light source parameters, such as momentum compaction factor, natural chromaticity, energy stability and undulator spectra. In common with other facilities, a method of energy measurement based on resonant spin depolarisation has been developed at Diamond. In this paper we report on progress towards storage ring characterisation using this method, as well as describing the diagnostics developments that have enabled these measurements to be made

Preparations for Recoil Detection System at the Cooler T-Site

This research was sponsored by the National Science Foundation Grant NSF PHY-931478