Элементы природы в крымско–татарском народном искусстве

В статье рассматривается система образования элементов орнамента. Типы орнаментального искусства и принципы группировки элементов изобразительной формы. Цветовое решение в орнаменте.В статі розглядається система освіти елементів орнамента. Типи орнаментального мистецтва і принципи згрупування елементів образотворчої форми. Кольорове рішення в орнаменті.The system of ornament's elements is representative in this article. Same types of art's ornament and some principles of grouping art's elements are here. Color's design in ornament

The first titin (c.59926+1G > A) founder mutation associated with dilated cardiomyopathy

Cardiolog

Towards personalized treatment in cardiovascular disease : a molecular epidemiological approach

Patients who have experienced cardiovascular disease each differ in terms of their future risk, yet currently we have no ways to predict individual prognosis. Mass preventive treatment is therefore currently recommended for the group as a whole whereas in fact this group is highly heterogeneous and needs differentiation. This thesis is an effort to identify groups of patients sharing a certain risk and its underlying pathological substrates which can be influenced. These are key insights to enable more effective and efficient personalized treatment of patients

ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting

Vascular Biology and Interventio

Metabolic syndrome in an Hispanic population–cardiovascular complications

The metabolic syndrome (MetS) is presently one of the main medical problems in developing countries. This syndrome was studied in Puerto Rico at the Cardiovascular Center of Puerto Rico and the Caribbean with emphasis on understanding the cardiovascular complications. The medical records of patients admitted between 1999 to 2005 were evaluated for three or more MetS diagnostic criteria. One hundred and seventy-three patients met the consensus criteria of metabolic syndrome (MetS). The mean age of those diagnosed with MetS was 60 years of age. Fifty-seven percent were males and 42 percent females. The mean body mass was 30 kg/m. The ejection fraction was found to be subnormal (49±8%) and the end systolic dimension of the left atrium was increased ( 45±10 mm ) in comparison to a group of diabetic patients without MetS used for comparison. The incidence of atrial fibrillation was found to be 16% higher in the MetS group than in the comparison group. The number of cases of metabolic syndrome recorded within the Hispanic population of Puerto Rico showed a higher incidence of atrial fibrillation without ventricular tachycardia. This is thought to be as a result of the abnormal left ventricular and atrial function

Absence of Connexin 40 gene polymorphism, as a marker of undetected atrial fibrillation in patients with unexplained cerebral ischemic events

Background - Atrial fibrillation (AF) is a major cause of cerebral infarction. Idiopathic AF is strongly associated with the human minor Connexin 40 (Cx40) promotor polymorphism. We examined the prevalence of the minor Cx40 allele in patients with cerebral ischemia and no other cardiovascular disease (CVD), as an indication of underlying idiopathic AF. Methods - In patients with cerebral ischemia without prior CVD (n=225), DNA analysis of the Cx40 minor allele (-44 G¿A) was performed. Patients were divided into those with a normal electrocardiographic (ECG) findings (group A, n=164), with ECG abnormalities (group B, n=51) and those with normal ECG and documented episodes of AF (group C, n=10). On the basis of echocardiography (ECHO) data availability, further subgroups were defined: normal ECG and ECHO (group D, n=45); ECG or ECHO abnormalities (group E, n=22); and normal ECG and ECHO and documented AF episodes (group F, n=8). The prevalence of Cx40 promotor polymorphism was compared among all the subgroups. Results - The average age was 58.7 years (±11.5) and 64.4% were men. Patients with episodes of AF and those with abnormal ECG or ECHO results (B+C or E+F) did not show a higher prevalence of the minor allele genotype (AA vs. GG) compared with the normal ECG/ECHO groups (A or D) (group A, odds ratio=1.04, 95% confidence interval: 0.26–4.11 and group D, odds ratio=0.38, 95% confidence interval: 0.04–3.63). Conclusion - In patients with cerebral ischemic events, without prior CVD, a higher prevalence of the Cx40 gene polymorphism, as a marker of underlying idiopathic AF appeared to be absen

Absence of Connexin 40 gene polymorphism, as a marker of undetected atrial fibrillation in patients with unexplained cerebral ischemic events

Background - Atrial fibrillation (AF) is a major cause of cerebral infarction. Idiopathic AF is strongly associated with the human minor Connexin 40 (Cx40) promotor polymorphism. We examined the prevalence of the minor Cx40 allele in patients with cerebral ischemia and no other cardiovascular disease (CVD), as an indication of underlying idiopathic AF. Methods - In patients with cerebral ischemia without prior CVD (n=225), DNA analysis of the Cx40 minor allele (-44 G¿A) was performed. Patients were divided into those with a normal electrocardiographic (ECG) findings (group A, n=164), with ECG abnormalities (group B, n=51) and those with normal ECG and documented episodes of AF (group C, n=10). On the basis of echocardiography (ECHO) data availability, further subgroups were defined: normal ECG and ECHO (group D, n=45); ECG or ECHO abnormalities (group E, n=22); and normal ECG and ECHO and documented AF episodes (group F, n=8). The prevalence of Cx40 promotor polymorphism was compared among all the subgroups. Results - The average age was 58.7 years (±11.5) and 64.4% were men. Patients with episodes of AF and those with abnormal ECG or ECHO results (B+C or E+F) did not show a higher prevalence of the minor allele genotype (AA vs. GG) compared with the normal ECG/ECHO groups (A or D) (group A, odds ratio=1.04, 95% confidence interval: 0.26–4.11 and group D, odds ratio=0.38, 95% confidence interval: 0.04–3.63). Conclusion - In patients with cerebral ischemic events, without prior CVD, a higher prevalence of the Cx40 gene polymorphism, as a marker of underlying idiopathic AF appeared to be absen

The hypertension peril: lessons from CETP inhibitors

Pharmacologic inhibitors of the cholesteryl ester transfer protein (CETP) are capable of increasing HDL cholesterol by 50% to 100% in humans. Despite intriguing antiatherogenic effects of CETP inhibition in animal models of atherosclerosis, the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial investigators observed an excess of cardiovascular and noncardiovascular morbidity and mortality associated with the use of the CETP inhibitor torcetrapib. This review summarizes available clinical and experimental data about potential underlying mechanisms