Bony ingrowth potential of 3D-printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model.

Background contextThere is significant variability in the materials commonly used for interbody cages in spine surgery. It is theorized that three-dimensional (3D)-printed interbody cages using porous titanium material can provide more consistent bone ingrowth and biological fixation.PurposeThe purpose of this study was to provide an evidence-based approach to decision-making regarding interbody materials for spinal fusion.Study designA comparative animal study was performed.MethodsA skeletally mature ovine lumbar fusion model was used for this study. Interbody fusions were performed at L2-L3 and L4-L5 in 27 mature sheep using three different interbody cages (ie, polyetheretherketone [PEEK], plasma sprayed porous titanium-coated PEEK [PSP], and 3D-printed porous titanium alloy cage [PTA]). Non-destructive kinematic testing was performed in the three primary directions of motion. The specimens were then analyzed using micro-computed tomography (µ-CT); quantitative measures of the bony fusion were performed. Histomorphometric analyses were also performed in the sagittal plane through the interbody device. Outcome parameters were compared between cage designs and time points.ResultsFlexion-extension range of motion (ROM) was statistically reduced for the PTA group compared with the PEEK cages at 16 weeks (p-value=.02). Only the PTA cages demonstrated a statistically significant decrease in ROM and increase in stiffness across all three loading directions between the 8-week and 16-week sacrifice time points (p-value≤.01). Micro-CT data demonstrated significantly greater total bone volume within the graft window for the PTA cages at both 8 weeks and 16 weeks compared with the PEEK cages (p-value<.01).ConclusionsA direct comparison of interbody implants demonstrates significant and measurable differences in biomechanical, µ-CT, and histologic performance in an ovine model. The 3D-printed porous titanium interbody cage resulted in statistically significant reductions in ROM, increases in the bone ingrowth profile, as well as average construct stiffness compared with PEEK and PSP

Observations of the Crab Nebula at energies 4.10(11)

Since the development of gamma-ray astronomical telescopes, the Crab Nebula has been a prime target for observations. From 100 to 1000 MeV, the pulsar PSR0531 is the dominant source with a light-curve similar to that seen at lower energies; there is also some evidence for longterm amplitude variations but none for emission from the Nebula itself. In the very high energy gamma-ray region there have been reported detections of pulsed emission with longterm time variations from minutes to months. Recently a pulsed flux has been reported that resisted over a long time interval. The detection of a flux from the Nebula at the 3 sigma level at energies of 3x1011eV was reported; there was no evidence of periodic emissions on any time scale during the three years of observations. A new measurement of very high energy gamma rays from the Crab Nebula is reported using the imaging system on the Whipple Observatory 10m reflector

Gaps in the cloud cover? Comparing extinction measures in spiral disks

Dust in galaxies can be mapped by either the FIR/sub-mm emission, the optical or infrared reddening of starlight, or the extinction of a known background source. We compare two dust extinction measurements for a set of fifteen sections in thirteen nearby galaxies, to determine the scale of the dusty ISM responsible for disk opacity: one using stellar reddening and the other a known background source. In our earlier papers, we presented extinction measurements of 29 galaxies, based on calibrated counts of distant background objects identified though foreground disks in HST/WFPC2 images. For the 13 galaxies that overlap with the Spitzer Infrared Nearby Galaxies Survey (SINGS), we now compare these results with those obtained from an I-L color map. Our goal is to determine whether or not a detected distant galaxy indicates a gap in the dusty ISM, and hence to better understand the nature and geometry of the disk extinction. We find that distant galaxies are predominantly in low-extinction sections marked by the color maps, indicating that their number depends both on the cloud cover of {\it Spitzer}-resolved dust structures --mostly the spiral arms--and a diffuse, unresolved underlying disk. We note that our infrared color map (E[I-L]) underestimates the overall dust presence in these disks severely, because it implicitly assumes the presence of a dust screen in front of the stellar distribution.Comment: 22 pages, 2 figures, 3 tables, accepted for publication in A

Microscopic Surface Structure of Liquid Alkali Metals

We report an x-ray scattering study of the microscopic structure of the surface of a liquid alkali metal. The bulk liquid structure factor of the eutectic K67Na33 alloy is characteristic of an ideal mixture, and so shares the properties of an elemental liquid alkali metal. Analysis of off-specular diffuse scattering and specular x-ray reflectivity shows that the surface roughness of the K-Na alloy follows simple capillary wave behavior with a surface structure factor indicative of surface induced layering. Comparison of thelow-angle tail of the K67Na33 surface structure factor with the one measured for liquid Ga and In previously suggests that layering is less pronounced in alkali metals. Controlled exposure of the liquid to H2 and O2 gas does not affect the surface structure, indicating that oxide and hydride are not stable at the liquid surface under these experimental conditions.Comment: 12 pages, 3 figures, published in Phys. Rev.

The Priming Function of In-car Audio Instruction

Studies to date have focused on the priming power of visual road signs, but not the priming potential of audio road scene instruction. Here, the relative priming power of visual, audio and multisensory road scene instructions were assessed. In a lab-based study, participants responded to target road scene turns following visual, audio or multisensory road turn primes which were congruent or incongruent to the primes in direction, or control primes. All types of instruction (visual, audio, multisensory) were successful in priming responses to a road scene. Responses to multisensory-primed targets (both audio and visual) were faster than responses to either audio or visual primes alone. Incongruent audio primes did not affect performance negatively in the manner of incongruent visual or multisensory primes. Results suggest that audio instructions have the potential to prime drivers to respond quickly and safely to their road environment. Peak performance will be observed if audio and visual road instruction primes can be timed to co-occur

A prospective cohort study comparing the reactogenicity of trivalent influenza vaccine in pregnant and non-pregnant women

Background: Influenza vaccination during pregnancy can prevent serious illness in expectant mothers and provide protection to newborns; however, historically uptake has been limited due to a number of factors, including safety concerns. Symptomatic complaints are common during pregnancy and may be mistakenly associated with reactions to trivalent influenza vaccine (TIV). To investigate this, we compared post-vaccination events self-reported by pregnant women to events reported by non-pregnant women receiving TIV. Methods: A prospective cohort of 1,086 pregnant women and 314 non-pregnant female healthcare workers (HCWs) who received TIV between March-May 2014 were followed-up seven days post-vaccination to assess local and systemic adverse events following immunisation (AEFIs). Women were surveyed by text message regarding perceived reactions to TIV. Those reporting an AEFI completed an interview by telephone or mobile phone to ascertain details. Logistic regression models adjusting for age and residence were used to compare reactions reported by pregnant women and non-pregnant HCWs. Results: Similar proportions of pregnant women and non-pregnant, female HCWs reported ≥1 reaction following vaccination with TIV (13.0% and 17.3%, respectively; OR = 1.2 [95% CI: 0.8-1.8]). Non-pregnant, female HCWs were more likely to report fever or headache compared to pregnant women (OR: 4.6 [95% CI 2.1-10.3] and OR: 2.2 [95% CI 1.0-4.6], respectively). No other significant differences in reported symptoms were observed. No serious vaccine-associated adverse events were reported, and less than 2% of each group sought medical advice for a reaction. Conclusions: We found no evidence suggesting pregnant women are more likely to report adverse events following influenza vaccination when compared to non-pregnant female HCWs of similar age, and in some cases, pregnant women reported significantly fewer adverse events. These results further support the safety of TIV administered in pregnant women

Very Luminous Carbon Stars in the Outer Disk of the Triangulum Spiral Galaxy

Stars with masses in the range from about 1.3 to 3.5 Mo pass through an evolutionary stage where they become carbon stars. In this stage, which lasts a few Myr, these stars are extremely luminous pulsating giants. They are so luminous in the near-infrared that just a few of them can double the integrated luminosity of intermediate-age (0.6 to 2 Gyr) Magellanic Cloud clusters at 2.2 microns. Astronomers routinely use such near-infrared observations to minimize the effects of dust extinction, but it is precisely in this band that carbon stars can contribute hugely. The actual contribution of carbon stars to the outer disk light of evolving spiral galaxies has not previously been morphologically investigated. Here we report new and very deep near-IR images of the Triangulum spiral galaxy M33=NGC 598, delineating spectacular arcs of carbon stars in its outer regions. It is these arcs which dominate the near-infrared m=2 Fourier spectra of M33. We present near-infrared photometry with the Hale 5-m reflector, and propose that the arcs are the signature of accretion of low metallicity gas in the outer disk of M33.Comment: 4 pages, 4 figures. Revised version submitted to A&A Letter

Cosmic string loop distribution on all length scales and at any redshift

We analytically derive the expected number density distribution of Nambu-Goto cosmic string loops at any redshift soon after the time of string formation to today. Our approach is based on the Polchinski-Rocha model of loop formation from long strings which we adjust to fit numerical simulations and complement by a phenomenological modelling of gravitational backreaction. Cosmological evolution drives the loop distribution towards scaling on all length scales in both the radiation and matter era. Memory of any reasonable initial loop distribution in the radiation era is shown to be erased well before Big Bang Nucleosynthesis. In the matter era, the loop distribution reaches full scaling, up to some residual loops from the radiation era which may be present for extremely low string tension. Finally, the number density of loops below the gravitational cutoff is shown to be scale independent, proportional to a negative power of the string tension and insensitive to the details of the backreaction modelling. As an application, we show that the energy density parameter of loops today cannot exceed 10^(-5) for currently allowed string tension values, while the loop number density cannot be less than 10^(-6) per Mpc^3. Our result should provide a more robust basis for studying the cosmological consequences of cosmic string loops.Comment: 24 pages, 4 figures, uses iopart. References added, matches published versio

Secondary Lead Poisoning in Golden Eagle and Ferruginous Hawk Chicks consuming Shot Black-tailed Prairie Dogs, Thunder Basin National Grassland, Wyoming

Recreational shooting of black-tailed prairie dogs (Cynomys ludovicianus) is a common activity at Thunder Basin National Grassland (TBNG), Wyoming. The prairie dog carcasses left in the area are scavenged by coyotes (Canis latrans), raptors, and other animals. These scavengers are susceptible to lead (Pb) poisoning if they consume Pb bullet fragments or Pb shot when scavenging the shooter-killed prairie dogs. In 2000, a local rehabilitator noted an increase of Pb poisoning cases in raptors (L.Layton, pers. comm. 3/30/01) from the area. We collected several shooter-killed prairie dog carcasses from TBNG for determining if Pb fragments remained embedded in the tissue that potentially would be consumed by raptors. Radiographs showed fragments consistent with Pb to be present. In 2002, we conducted a more in-depth study to determine if Pb poisoning was occurring in raptors at TBNG by documenting the number of raptors on prairie dogs at colonies where shooting occurred, assaying bullet fragments in shot prairie dogs to determine Pb content, and analyzing blood and feather samples of ferruginous hawk (Buteo regalis) and golden eagle (Aquila chrysaetos) nestlings and feathers from burrowing owls (Athene cunicularia) for clinical signs of Pb poisoning. We observed raptors foraging at prairie dog colonies and collected data on the number of shooters shooting at prairie dog colonies. To determine if raptors preferred foraging on shot prairie dogs, we compared raptor use at prairie dog colonies where shooting occurred to raptor use at prairie dog colonies where shooting did not occur. Shooter intensity did not predict raptor use. We also collected prairie dog carcasses and examined them for Pb shot fragments. We detected metal fragments in four of ten prairie dog carcasses. The total weight of the fragments found in each carcass ranged from 10 – 146 mg. Copper was the primary metal detected in 3 of 4 carcasses; but, significant amounts of Pb (20 mg, 28 mg, and 124 mg) were found in the three carcasses. Blood Pb concentrations in ferruginous hawk nestlings were below sub-clinical levels at TBNG and the control site near Rawlins, Wyoming. Analysis of red blood cell delta-aminolevulinic acid dehydratase activity, hemoglobin levels, and protoporphyrin levels also did not indicate Pb poisoning in ferruginous hawk nestlings. Additionally, blood and feather samples from golden eagle nestlings and feather samples from burrowing owls (juveniles and adults) at TBNG did not indicate Pb poisoning. Although ferruginous hawks and golden eagles (and possibly burrowing owls) scavenge on the carcasses of shot prairie dogs and some carcasses contained Pb-bullet fragments, we did not detect Pb poisoning in any of the birds. Lead poisoning may become important if the availability of alternate food sources decreases or shooter intensity increases