Indoramin pregnancy in the treatment hypertension of A placebo-controlled trial comparing the efficacy of indoramin with alpha-methyldopa

A placebo-controlled trial was used to assess the antihypertensive efficacy of indoramin in the management of pregnancy hypertension. Sixty patients were recruited into the study and only 17 attained satisfactory blood pressure control. In the doses of drugs administered indoramin was not shown to be more effective than alpha-methyldopa

Bioinspired low-frequency material characterisation

New-coded signals, transmitted by high-sensitivity broadband transducers in the 40–200 kHz range, allow subwavelength material discrimination and thickness determination of polypropylene, polyvinylchloride, and brass samples. Frequency domain spectra enable simultaneous measurement of material properties including longitudinal sound velocity and the attenuation constant as well as thickness measurements. Laboratory test measurements agree well with model results, with sound velocity prediction errors of less than 1%, and thickness discrimination of at least wavelength/15. The resolution of these measurements has only been matched in the past through methods that utilise higher frequencies. The ability to obtain the same resolution using low frequencies has many advantages, particularly when dealing with highly attenuating materials. This approach differs significantly from past biomimetic approaches where actual or simulated animal signals have been used and consequently has the potential for application in a range of fields where both improved penetration and high resolution are required, such as nondestructive testing and evaluation, geophysics, and medical physics

Magnetic Reconnection in Extreme Astrophysical Environments

Magnetic reconnection is a basic plasma process of dramatic rearrangement of magnetic topology, often leading to a violent release of magnetic energy. It is important in magnetic fusion and in space and solar physics --- areas that have so far provided the context for most of reconnection research. Importantly, these environments consist just of electrons and ions and the dissipated energy always stays with the plasma. In contrast, in this paper I introduce a new direction of research, motivated by several important problems in high-energy astrophysics --- reconnection in high energy density (HED) radiative plasmas, where radiation pressure and radiative cooling become dominant factors in the pressure and energy balance. I identify the key processes distinguishing HED reconnection: special-relativistic effects; radiative effects (radiative cooling, radiation pressure, and Compton resistivity); and, at the most extreme end, QED effects, including pair creation. I then discuss the main astrophysical applications --- situations with magnetar-strength fields (exceeding the quantum critical field of about 4 x 10^13 G): giant SGR flares and magnetically-powered central engines and jets of GRBs. Here, magnetic energy density is so high that its dissipation heats the plasma to MeV temperatures. Electron-positron pairs are then copiously produced, making the reconnection layer highly collisional and dressing it in a thick pair coat that traps radiation. The pressure is dominated by radiation and pairs. Yet, radiation diffusion across the layer may be faster than the global Alfv\'en transit time; then, radiative cooling governs the thermodynamics and reconnection becomes a radiative transfer problem, greatly affected by the ultra-strong magnetic field. This overall picture is very different from our traditional picture of reconnection and thus represents a new frontier in reconnection research.Comment: Accepted to Space Science Reviews (special issue on magnetic reconnection). Article is based on an invited review talk at the Yosemite-2010 Workshop on Magnetic Reconnection (Yosemite NP, CA, USA; February 8-12, 2010). 30 pages, no figure

Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment

The clinical course of pituitary adenoma can be highly variable. Aggressive pituitary tumours may require multimodal therapy with multiple operations. Even standard pituitary adenomas exhibit relatively high long‐term recurrence rates and delayed intervention is often required. The indications for revision surgery in the endoscopic era are expanding for both functioning and nonfunctioning tumours, including access to the cavernous sinus and intracranial compartments. Although revision surgery can be challenging, it has been demonstrated to be both safe and effective. The question of the use of early radiotherapy in pituitary adenoma remains controversial. Our increasing understanding of pituitary tumour biology facilitates individualized treatment and surveillance protocols, with early intervention in high‐risk adenoma subtypes. In this review, we discuss the treatment options for recurring pituitary tumours and focus on the role of revision surgery

Low frequency acoustic and ultrasound waves to characterise layered media

Poor penetration and excessive absorption of high frequencies limit spectroscopic approaches using fast rise pulses for inspecting many engineered structures. So, this study focused on the alternative application of low frequency acoustic and ultrasound waves for the characterisation of challenging structures in airborne and waterborne environments. A simple, transfer matrix model approach was developed for the simulation of 1D sound propagation through layered media that comprise many engineered structures. This model was used to test the feasibility of using sound waves for non-destructive characterisation of an articulated lorry transported trailer and offshore foundation infrastructure. The targets were not in contact with the sound sensors and incorporated highly attenuating layers with acoustic contrasts to the surrounding medium that result in over 90% reflection of incident wave pressure. In both cases, resonances controlled by the thicknesses and interval velocities of component layers modulated sound reflection from, and transmission through the whole structure. These effects were observed as local maxima and minima in the spectra of the transmission and reflection coefficients. These spectral coefficients also determined the modulation to the temporal envelope of a linear frequency modulated pulse used to insonify the targets. In the acoustic study, which comprised only theoretical modelling, discrimination of differing cargo widths and between solid versus empty cargo trailers was possible using the transmission coefficient. In the ultrasound study, which comprised theoretical modelling and experimental testing, discrimination of differing steel and concrete substructure thicknesses and also of gaps between them was possible using the reflection coefficient. The model outcomes indicated while an acoustic system would require around 90–100 dB of dynamic range, an ultrasound system would only require around 40 dB to be effective

Comparative empirical evaluations of internal migration models in subnational population projections

While population forecasters place considerable emphasis on the selection of appropriate migration assumptions, surprisingly little attention has been given to the effects on projection outcomes of the way internal migration is handled within population projection models. This paper compares population projections for Australia's states and territories prepared using ten different internal migration models but with identical assumptions for fertility, mortality and international migration and with the internal migration model parameters held constant. It is shown that the choice of migration model generates large differences in total population, geographical distribution and age--sex composition. It is argued that model choice should be guided by balancing model reality with practical utility and model performance is examined against these criteria. Of the ten models evaluated the authors argue that the migration pool, biregional, and biregional with net constraints models offer a good compromise between conceptual rigour and practicality. If the projected origin-destination flows are required then one of the versions of the standard multiregional model with reduced data inputs is preferred. The large variation in projection outputs points to the need for a better understanding of the spatio-temporal structure of migration in Australia

Gamma Ray Bursts as Probes of Quantum Gravity

Gamma ray bursts (GRBs) are short and intense pulses of $\gamma$-rays arriving from random directions in the sky. Several years ago Amelino-Camelia et al. pointed out that a comparison of time of arrival of photons at different energies from a GRB could be used to measure (or obtain a limit on) possible deviations from a constant speed of light at high photons energies. I review here our current understanding of GRBs and reconsider the possibility of performing these observations.Comment: Lectures given at the 40th winter school of theretical physics: Quantum Gravity and Phenomenology, Feb. 2004 Polan

Ultrasonic testing of laboratory samples representing monopile wind turbine foundations

Wind energy turbines and offshore hydrocarbon platforms rely on injected concrete grout to support and transfer loads between steel substructures. Deterioration of this grout under large operational stresses can lead to a loss of bonding, the formation of gaps, crushing and the loss of grout from the annulus between the steel substructures. In this paper, the integrity of the grout between two steel panels is experimentally tested using a low-frequency ultrasound backscatter method[1]. The experimental results and modelled outcomes[1] are compared for grout condition classes, including: good condition, gaps between the grout and either steel panel and the complete absence of grout. Pearson correlation coefficients of over 83% are observed when comparing the notch magnitudes and the frequencies on the modelled and experimental reflectance spectra of the front and rear gap, as well as missing grout conditions. Kolmogorov-Smirnov (K-S) similarity tests on the modelled and experimental notch magnitudes indicate a 20% significance on the rear gap and front gap spectra and a 10% significance on the missing grout spectra. The significance of these tests supports the potential application of backscattered low-frequency ultrasound for grout condition inspection. However, development of automated condition recognition algorithms, based on either spectral characteristics or time-localised spectral features of the backscatter, is required to make routine inspection commercially viable

Role of hyaluronan in human adipogenesis : evidence from in-vitro and in-vivo studies

Hyaluronan (HA), an extra-cellular matrix glycosaminoglycan, may play a role in mesenchymal stem cell differentiation to fat but results using murine models and cell lines are conflicting. Our previous data, illustrating decreased HA production during human adipogenesis, suggested an inhibitory role. We have investigated the role of HA in adipogenesis and fat accumulation using human primary subcutaneous preadipocyte/fibroblasts (PFs, n = 12) and subjects of varying body mass index (BMI). The impact of HA on peroxisome proliferator-activated receptor gamma (PPARγ) expression was analysed following siRNA knockdown or HA synthase (HAS)1 and HAS2 overexpression. PFs were cultured in complete or adipogenic medium (ADM) with/without 4-methylumbelliferone (4-MU = HA synthesis inhibitor). Adipogenesis was evaluated using oil red O (ORO), counting adipogenic foci, and measurement of a terminal differentiation marker. Modulating HA production by HAS2 knockdown or overexpression increased (16%, p < 0.04) or decreased (30%, p = 0.01) PPARγ transcripts respectively. The inhibition of HA by 4-MU significantly enhanced ADM-induced adipogenesis with 1.52 ± 0.18- (ORO), 4.09 ± 0.63- (foci) and 2.6 ± 0.21-(marker)-fold increases compared with the controls, also increased PPARγ protein expression (40%, (p < 0.04)). In human subjects, circulating HA correlated negatively with BMI and triglycerides (r = −0.396 (p = 0.002), r = −0.269 (p = 0.038), respectively), confirming an inhibitory role of HA in human adipogenesis. Thus, enhancing HA action may provide a therapeutic target in obesity

Agro-materials : a bibliographic review

Facing the problems of plastic recycling and fossil resources exhaustion, the use of biomass to conceive new materials appears like a reasonable solution. Two axes of research are nowadays developed : on the one hand the synthesis of biodegradable plastics, whichever the methods may be, on the other hand the utilization of raw biopolymers, which is the object of this paper. From this perspective, the “plastic” properties of natural polymers, the caracteristics of the different classes of polymers, the use of charge in vegetable matrix and the possible means of improving the durability of these agro-materials are reviewed