Yes-no Bloom filter: A way of representing sets with fewer false positives

The Bloom filter (BF) is a space efficient randomized data structure particularly suitable to represent a set supporting approximate membership queries. BFs have been extensively used in many applications especially in networking due to their simplicity and flexibility. The performances of BFs mainly depends on query overhead, space requirements and false positives. The aim of this paper is to focus on false positives. Inspired by the recent application of the BF in a novel multicast forwarding fabric for information centric networks, this paper proposes the yes-no BF, a new way of representing a set, based on the BF, but with significantly lower false positives and no false negatives. Although it requires slightly more processing at the stage of its formation, it offers the same processing requirements for membership queries as the BF. After introducing the yes-no BF, we show through simulations, that it has better false positive performance than the BF

Information-Centric Multilayer Networking: Improving Performance Through an ICN/WDM Architecture

Information-centric networking (ICN) facilitates content identification in networks and offers parametric representation of content semantics. This paper proposes an ICN/WDM network architecture that uses these features to offer superior network utilization, in terms of performance and power consumption. The architecture introduces an ICN publish/subscribe communication approach to the wavelength layer, whereby content is aggregated according to its popularity rank into wavelength-size groups that can be published and subscribed to by multiple nodes. Consequently, routing and wavelength assignment (RWA) algorithms benefit from anycast to identify multiple sources of aggregate content and allow optimization of the source selection of light paths. A power-aware algorithm, maximum degree of connectivity, has been developed with the objective of exploiting this flexibility to address the tradeoff between power consumption and network performance. The algorithm is also applicable to IP architectures, albeit with less flexibility. Evaluation results indicate the superiority of the proposed ICN architecture, even when utilizing conventional routing methods, compared with its IP counterpart. The results further highlight the performance improvement achieved by the proposed algorithm, compared with the conventional RWA methods, such as shortest-path first fit

Tributyltin (TBT) and the decline of the Norfolk Broads

This is the final report to the Department for Environment, Food & Rural Affairs (DEFRA) on the contract "Tributyltin (TBT) and the decline of the Norfolk Broads"

On the size and orientation effect in additive manufactured Ti-6Al-4V

In this work, the influence of the specimen size and orientation on the strength and ductility of additive manufactured Ti-6Al-4V is analysed and rationalised in a complete framework. First, the mechanical properties are addressed – as a function of surface-type, orientation, and size. Our results show systematic strengthening and a drastic drop in ductility as the material section is reduced. These changes are rationalised and linked to changes in microstructure, chemistry, and surface quality. Strengthening is due to combined changes in α-lath thickness, oxygen enrichment, and prior-β grain size. The microstructural changes are due to the differences in the ratio between contouring and hatching laser strategies as the sample size decreases. Changes in the chemical composition is due to an increase in the surface-to-volume ratio as the sample size decreases. Lost of ductility is due to poor surface quality – smaller sections show rougher surfaces – and grain orientations. Finally, these findings are used to develop a set of conceptual design maps of strength and ductility as a function of the component type, thickness, and orientation

Contribution of murine IgG Fc regions to antibody binding to the capsule of Burkholderia pseudomallei.

Immunoglobulin G3 (IgG3) is the predominant IgG subclass elicited in response to polysaccharide antigens in mice. This specific subclass has been shown to crosslink its fragment crystallizable (Fc) regions following binding to multivalent polysaccharides. Crosslinking leads to increased affinity through avidity, which theoretically should lead to more effective protection against bacteria and yeast displaying capsular polysaccharides on their surface. To investigate this further we have analyzed the binding characteristics of 2 IgG monoclonal antibody (mAb) subclass families that bind to the capsular polysaccharide (CPS) of Burkholderia pseudomallei. The first subclass family originated from an IgG3 hybridoma cell line (3C5); the second family was generated from an IgG1 cell line (2A5). When the Fc region of the 3C5 IgG3 is removed by proteolytic cleavage, the resulting F(ab')2 fragments exhibit decreased affinity compared to the full-length mAb. Similarly, when the parent IgG3 mAb is subclass-switched to IgG1, IgG2b, and IgG2a, all of these subclasses exhibit decreased affinity. This decrease in affinity is not seen when the 2A5 IgG1 mAb is switched to an IgG2b or IgG2a, strongly suggesting the drop in affinity is related to the IgG3 Fc region

Knockout studies reveal an important role of <i>plasmodium</i> lipoic acid protein ligase a1 for asexual blood stage parasite survival

Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation. The cofactor is post-translationally attached to the acyl-transferase subunits of the multienzyme complexes through the action of octanoyl (lipoyl): &lt;i&gt;N&lt;/i&gt;-octanoyl (lipoyl) transferase (LipB) or lipoic acid protein ligases (LplA). Remarkably, apicomplexan parasites possess LA biosynthesis as well as scavenging pathways and the two pathways are distributed between mitochondrion and a vestigial organelle, the apicoplast. The apicoplast-specific LipB is dispensable for parasite growth due to functional redundancy of the parasite's lipoic acid/octanoic acid ligases/transferases. In this study, we show that &lt;i&gt;LplA1&lt;/i&gt; plays a pivotal role during the development of the erythrocytic stages of the malaria parasite. Gene disruptions in the human malaria parasite &lt;i&gt;P.falciparum&lt;/i&gt; consistently were unsuccessful while in the rodent malaria model parasite &lt;i&gt;P. berghei&lt;/i&gt; the &lt;i&gt;LplA1&lt;/i&gt; gene locus was targeted by knock-in and knockout constructs. However, the &lt;i&gt;LplA1&lt;/i&gt; &lt;sup&gt;(-)&lt;/sup&gt; mutant could not be cloned suggesting a critical role of LplA1 for asexual parasite growth &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. These experimental genetics data suggest that lipoylation during expansion in red blood cells largely occurs through salvage from the host erythrocytes and subsequent ligation of LA to the target proteins of the malaria parasite

Electronic stress tensor analysis of hydrogenated palladium clusters

We study the chemical bonds of small palladium clusters Pd_n (n=2-9) saturated by hydrogen atoms using electronic stress tensor. Our calculation includes bond orders which are recently proposed based on the stress tensor. It is shown that our bond orders can classify the different types of chemical bonds in those clusters. In particular, we discuss Pd-H bonds associated with the H atoms with high coordination numbers and the difference of H-H bonds in the different Pd clusters from viewpoint of the electronic stress tensor. The notion of "pseudo-spindle structure" is proposed as the region between two atoms where the largest eigenvalue of the electronic stress tensor is negative and corresponding eigenvectors forming a pattern which connects them.Comment: 22 pages, 13 figures, published online, Theoretical Chemistry Account

Mortality after emergency department intubation

Introduction The purpose of this study is to identify the rate of emergency department (ED) intubation and the mortality associated with ED intubation. Methods We conducted a retrospective chart review of all patients intubated in the ED between 1 January 2004 an