Entenent les lesions de medul·la espinal

Una tesi llegida a la UAB ha utilitzat la rata com a model de lesió espinal toràcica per a estudiar com en lesions de la mèdula espinal, l'afectació motora i els mecanismes medul·lars alterats contribueixen al dolor neuropàtic, aquell dolor que no presenta cap funció protectora, es a dir, que aparentment no serveix per evitar danys a l'organisme. Aquesta tesi, que destaca la existència d'alteracions al llarg de tota la via sensitiva, també assenyala la necessitat de dissenyar nous tractaments que vagin més enllà de tractar només la zona de la lesió.Una tesis leída en la UAB ha utilizado la rata como modelo de lesión espinal torácica para estudiar cómo en lesiones de la médula espinal, la afectación motora y los mecanismos medulares alterados contribuyen al dolor neuropático, ese dolor que no presenta ningúna función protectora, es decir, que aparentemente no sirve para evitar daños al organismo. Esta tesis, que destaca la existencia de alteraciones a lo largo de toda la vía sensitiva, también señala la necesidad de diseñar nuevos tratamientos que vayan más allá de tratar sólo la zona de la lesión

Changes in the secretome of tri-dimensional spheroid-cultured human mesenchymal stem cells in vitro by interleukin-1 priming

Funding The work was supported with funds from the Stroke Association and from EPSRC, MRC Centre for Doctoral Training in Regenerative Medicine studentship grant EP/L014904/1, and the Manchester Regenerative Medicine Network (MaRM). Availability of data and materials The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.Peer reviewedPublisher PD

Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia

Research on microglia has established the differentiation between the so-called M1 and M2 phenotypes. However, new frameworks have been proposed attempting to discern between meaningful microglia profiles. We have set up an in vitro microglial activation model by adding an injured spinal cord (SCI) lysate to microglial cultures, obtained from postnatal rats, in order to mimic the environment of the spinal cord after injury. We found that under the presence of the SCI lysate microglial cells changed their phenotype, developing less ramified but longer processes, and proliferated. The SCI lysate also led to upregulation of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, downregulation of the anti-inflammatory cytokines IL-10 and IL-4, and a biphasic profile of iNOS. In addition, a latex beads phagocytosis assay revealed the SCI lysate stimulated the phagocytic capacity of microglia. Flow cytometry analysis indicated that microglial cells showed a pro-inflammatory profile in the presence of SCI lysate. Finally, characterization of the microglial activation in the spinal cord on day 7 after contusion injury, we showed that these cells have a pro-inflammatory phenotype. Overall, these results indicate that the use of SCI lysates could be a useful tool to skew microglia towards a closer phenotype to that observed after the spinal cord contusion injury than the use of LPS or IFNγ

Evaluation of the CHUMS Child Bereavement Group : A Pilot Study Examining Statistical and Clinical Change

This is an Accepted Manuscript of an article published by Taylor & Francis in Death Studies on 7 February 2015, available online at: http://dx.doi.org/10.1080/07481187.2014.913085.This article describes the largest evaluation of a UK child bereavement service to date. Change was assessed using conventional statistical tests as well as clinical significance methodology. Consistent with the fact that the intervention was offered on a universal, preventative basis, bereaved young people experienced a statistically significant, small to medium-sized decrease in symptoms over time. This change was equivalent across child age and gender. Type of bereavement had a slight impact on change when rated by parents. Potential clinical implications are highlighted, and various limitations are discussed that we hope to address using an experimental design in future researchPeer reviewedFinal Accepted Versio

Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015

Objective: To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000-2015. Methods: We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). We collected data on sex, age, type of discharge, main diagnosis, comorbid diagnosis, length of stay, and global cost. All the hospitalizations were grouped by age into three categories: 65-74 years old, 75-84 years old, and 85 years old and above. In the descriptive statistical analysis, crude rates were defined as hospitalizations per 1,000 inhabitants aged ≥65. To identify trends over time, we performed a Joinpoint regression. Results: From 2000-2015, we found 387,010 hospitalizations coded as UTIs (54,427 pyelonephritis, 15,869 prostatitis, 2643 cystitis and 314,071 non-specified UTI). The crude rate of hospitalization for UTIs between 2000 and 2015 ranged from 2.09 in 2000 to 4.33 in 2015 Rates of hospitalization were higher in men than in women, except with pyelonephritis. By age group, higher rates were observed in patients aged 85 years or older, barring prostatitis-related hospitalizations. Joinpoint analyses showed an average annual percentage increase (AAPC) in incidence rates of 4.9% (95% CI 3.2;6.1) in UTI hospitalizations. We observed two joinpoints, in 2010 and 2013, that found trends of 5.5% between 2000 and 2010 (95% CI 4.7;6.4), 1.5% between 2010 and 2013 (95% CI -6.0;9.6) and 6.8% between 2013 and 2015 (95% CI -0.3;14.4). Conclusions: The urinary infection-related hospitalization rate in Spain doubled during the period 2000-2015. The highest hospitalization rates occurred in men, in the ≥85 years old age group, and in non-specified UTIs. There were increases in all types of urinary tract infection, with non-specified UTIs having the greatest growth. Understanding these changing trends can be useful for health planning.This study has been funded by Instituto de Salud Carlos III through the project “PI19/01700”, as part of the Plan Estatal de I+D+I 2017-2020 co-funded by European Regional Development Fund (ERDF) “A way of shaping Europe”. In addition, the principal investigator JRS received support to increase his research activities and to publish this manuscript from the 2020 funding program of the Fundación de Investigación e Innovación Biosanitaria en Atención Primaria (FIIBAP), Community of Madrid.S

Memoria del IV Certamen Universitario de Microrrelatos sobre Asia

Este documento contiene los objetivos, metodología, resultados y evaluación del proyecto IV Certamen Universitario de Microrrelatos sobre Asia. Un proyecto colaborativo entre investigadores y alumnos que busca el intercambio, la formación de los jóvenes, y la generación de material didáctico sobre Asia abierto a la comunidad