Career readiness for all

The goal of the Coalition for Career Development is to make career readiness the first priority of American education. Our vision is to ensure that ALL students secure productive employment in their chosen pathway as efficiently and cost-effectively as possible.Accepted manuscrip

Reactivity of Acyclic (pentadienyl)iron(1+) Cations with Phosphonate Stabilized Nucleophiles: Application to the Synthesis of Oxygenated Metabolites of Carvone

The addition of phosphonate stabilized carbon nucleophiles to acyclic (pentadienyl)iron(1+) cations proceeds predominantly at an internal carbon to afford (pentenediyl)iron complexes. Those complexes bearing an electron withdrawing group at the σ-bound carbon (i.e., 13/14) are stable and isolable, while complexes which do not contain an electron withdrawing group at the σ-bound carbon undergo CO insertion, reductive elimination and conjugation of the double bond to afford cyclohexenone products (21/22). Deprotonation of the phosphonate 13/14 or 21 and reaction with paraformaldehyde affords the olefinated products. This methodology was utilized to prepare oxygenated carvone metabolites (±)-25 and (±)-26

The Astrophysics Science Division Annual Report 2009

The Astrophysics Science Division (ASD) at Goddard Space Flight Center (GSFC) is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum - from gamma rays to radio wavelengths - as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for three orbiting astrophysics missions - WMAP, RXTE, and Swift, as well as the Science Support Center for the Fermi Gamma-ray Space Telescope. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, space-based interferometry, high contrast imaging techniques to search for exoplanets, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. The overriding goals of ASD are to carry out cutting-edge scientific research, provide Project Scientist support for spaceflight missions, implement the goals of the NASA Strategic Plan, serve and support the astronomical community, and enable future missions by conceiving new concepts and inventing new technologies

The Astrophysics Science Division Annual Report 2008

The Astrophysics Science Division (ASD) at Goddard Space Flight Center (GSFC) is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum from gamma rays to radio wavelengths as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for three orbiting astrophysics missions WMAP, RXTE, and Swift, as well as the Science Support Center for the Fermi Gamma-ray Space Telescope. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. This report includes the Division's activities during 2008

Probing the Human Estrogen Receptor-α Binding Requirements for Phenolic Mono- and Di-Hydroxyl Compounds: A Combined Synthesis, Binding and Docking Study

Various estrogen analogs were synthesized and tested for binding to human ERα using a fluorescence polarization displacement assay. Binding affinity and orientation were also predicted using docking calculations. Docking was able to accurately predict relative binding affinity and orientation for estradiol, but only if a tightly bound water molecule bridging Arg394/Glu353 is present. Di-hydroxyl compounds sometimes bind in two orientations, which are flipped in terms of relative positioning of their hydroxyl groups. Di-hydroxyl compounds were predicted to bind with their aliphatic hydroxyl group interacting with His524 in ERα. One nonsteroid-based dihdroxyl compound was 1000-fold specific for ERβ over ERα, and was also 25-fold specific for agonist ERβ versus antagonist activity. Docking predictions suggest this specificity may be due to interaction of the aliphatic hydroxyl with His475 in the agonist form of ERβ, versus with Thr299 in the antagonist form. But, the presence of this aliphatic hydroxyl is not required in all compounds, since mono-hydroxyl (phenolic) compounds bind ERα with high affinity, via hydroxyl hydrogen bonding interactions with the ERα Arg394/Glu353/water triad, and van der Waals interactions with the rest of the molecule

A lack of response of irrigated soybean (Glycine max L. Merr.) in rotation with cotton (Gossypium hirsutum L.) in the Mississippi Delta, USA

The effects of cotton (Gossypium hirsutum L.): soybean [Glycine max (L.) Merr.] rotations on the respective crops are limited. This manuscript discusses the response of irrigated soybean in crop rotation with cotton. An irrigated soybean: cotton rotation experiment was conducted from the year 2012 through 2015 near Elizabeth, MS. The crop rotation sequences were included continuous soybean (SSSS), continuous cotton (CCCC), cotton followed by soybean (SCSC), soybean followed by cotton (CSCS), soybean followed by two year of cotton (SCCS), and cotton followed by two year of soybean (CSSC). The rotations were grown under two production systems conventional and transgenetic with respect to weed control. During this study, a weed control treatment of (pendimethalin pre-emergence vs. glyphosate post-emergence) as included on the soybean plots was used. The soybean yields across rotations within a year were not significantly different. The means yields differed among years (3655.1, 3023.6, 3500.6 and 2600.3 Kg ha-1 for the year 2012, 2013, 2014 and 2015, respectively) and appear related to difference in rainfall/irrigation amounts. The results revealed that the weights of 100 seed samples averaged 13.9g in the year 2015 which differed from the previous years (16.2, 15.6, and 16.2g; 2012, 2013 and 2014, respectively). Therefore, the rotations of cotton with soybean appear to have neither a beneficial or negative effect on soybean yield

CORRELATION BETWEEN GLYCEMIC CONTROL AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS: HbA1c AS AN INDIRECT INDICATOR OF DYSLIPIDEMIA

Objectives: Dyslipidemia is one of the major risk factor for cardiovascular disease in Type 2 Diabetes mellitus, characterized by elevated Total cholesterol (TC), Triglycerides (TG), Low density lipoprotein (LDL) and decreased High density lipoprotein (HDL). Hemoglobin A1c (HbA1c) is widely used as an index of mean glycaemia, a measure of risk for the development of diabetes complications and a measure of the quality of diabetes care. The aim of this study was to determine the impact of glycemic control on lipid profile and to know utility of HbA1c as an indirect indicator of dyslipidemia.Methods: A total of 490 Type 2 Diabetes mellitus patients (males 258, females 232) mean age 53.17 years standard deviation (S.D) 10.50 were included in this study.Results: The age of type 2 diabetic patients were not significantly correlated with fasting blood glucose and HbA1c. The level of HbA1c was highly direct significant correlation with fasting blood glucose. The Age of Type 2 Diabetic patients were highly significant and inversely correlated with Total cholesterol, Triglycerides, Low-density Lipoprotein, where it was not significantly correlated with High-density Lipoprotein. The level of HbA1c was highly direct significant correlation with TC, TG, LDL, where it was not correlated with HDL.Conclusion: The findings of this study clearly showed that HbA1c is not only a reliable glycemic index but also as an indirect indicator of dyslipidemia.Keywords: Type 2 diabetes mellitus, HbA1c, Lipid profile, Dyslipidemia

Synthetic studies directed toward guianolides: an organoiron route to the 5,7,5 tricyclic ring system

A diastereoselective route to the 5,7,5-tricyclic core of the guianolides is presented. This route relies on Cope rearrangement of a divinylcyclopropane prepared by alkenyl Grignard addition to a (pentadienyl)iron(+1) cation, followed by oxidative decomplexation. An additional key reaction involves oxidative rearrangement of a 3,4-epoxy-1,7-diol to generate a γ-lactone. The relative stereochemistry of this product was established by X-ray crystallography