Ground-based salt seeding in Tamil nadu state, south India, 1973-1977

A long series of ground-based salt seeding experiments in north India during the southwest monsoonseasons (June-September) of 1957-66 showed significant increases of about 20 percent in rainfall on seeded days (Ramana Murty and Biswas, 1968). In September of 1974, salt seeding from aircraft on isolated maritime warm cumulus clouds within 50 km off the coast at Bombay(18 15’N, 72v 49’D, II m ASL) was followed by increases in radar echo area coverage in the vertical and in echo intensity (Chatterjee et al., 1978). seek similar results in a different area, a randomized salt-seeding experiment, using a single ground-based generator, was conducted in 1973 and 1975-77 just west of Madras, on the Bengal coast 1,000 km southeast of Bombay. There in the state of Tamil Nadu, South India, the main rainy season is during the northeast monsoon(Oct-Dec), whereas in most parts of India, about 75 percent of the annual rainfall is received during the southwest monsoon(Ananthakrishnan, 1977

Chronic Disease Self-Management Challenges among Rural Women Living with HIV/AIDS in Prakasam, Andhra Pradesh, India: A Qualitative Study.

Rural women living with HIV/AIDS (WLHA) in India experience challenges self-managing HIV/AIDS in their rural communities. The purpose of this qualitative study was to explore factors influencing their care and antiretroviral treatment (ART) adherence. Themes that emerged from the qualitative focus groups among WLHA (N = 24) in rural Prakasam, Andhra Pradesh, India, included: (1) coming to know about HIV and other health conditions, (2) experiences being on ART, (3) challenges maintaining a nutritious diet, (4) factors affecting health care access and quality, and (5) seeking support for a better future. Chronic disease self-management in rural locales is challenging, given the number of barriers which rural women experience on a daily basis. These findings suggest a need for individual- and structural-level supports that will aid in assisting rural WLHA to self-manage HIV/AIDS as a chronic illness

Whole-Genome Sequencing of Pigeonpea: Requirement, Background History, Current Status and Future Prospects for Crop Improvement

Despite of being a very important crop, pigeonpea did not have genomic resources until 2005. Pigeonpea Genomics Initiative (PGI) supported by Indian Council of Agricultural Research (ICAR) under Indo-US Agriculture Knowledge Initiative was the first major initiative that delivered first set of molecular markers in large numbers, first set of mapping populations, first set of transcriptome assemblies, etc. Subsequently, two consortia—1) International Initiative for Pigeonpea Genomics (IIPG), led by International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) and 2) Led by National Research Centre on Plant Biotechnology (NRCPB)—delivered two draft genome assemblies for Asha (ICPL 87119) variety. In summary, all these genomic resources transformed pigeonpea from an ‘orphan crop’ to ‘genomics resources-rich crop’. After publication of draft genome sequences, a detailed plan was developed to utilize draft genome information for pigeonpea improvement. This plan in the form of a proposal was approved by Ministry of Agriculture, Government of India and United States Agency for International Development (USAID)—India. In addition to this major project, two additional projects were funded by Department of Biotechnology, Government of India. All these efforts have established high-density genotyping platforms such as genotyping by sequencing (GBS) and ​‘Axiom® CajanusSNP Array’, produced the first generation HapMap, generated whole-genome re-sequencing data of >400 pigeonpea lines, evaluated several mapping populations for desired traits, established marker–trait association for several traits of interest to breeders and also identified best-performing lines. Additionally, multi-parent advance generation inter-cross (MAGIC) and nested association mapping (NAM) populations are being developed. With the availability of above-mentioned information, next few years will be witnessing application of genomics-assisted breeding for pigeonpea improvement. It is anticipated that improved pigeonpea lines developed through genomics interventions will reach to farmers’ fields and elevate the game towards pulse sufficiency for poor farmers in arid and semi-arid regions of the world in near future

A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments

The volatile compound dimethylsulphide (DMS) is important in climate regulation, the sulphur cycle and signalling to higher organisms. Microbial catabolism of the marine osmolyte dimethylsulphoniopropionate (DMSP) is thought to be the major biological process generating DMS. Here we report the discovery and characterisation of the first gene for DMSP-independent DMS production in any bacterium. This gene, mddA, encodes a methyltransferase that methylates methanethiol (MeSH) and generates DMS. MddA functions in many taxonomically diverse bacteria including sediment-dwelling pseudomonads, nitrogen-fixing bradyrhizobia and cyanobacteria, and mycobacteria, including the pathogen Mycobacterium tuberculosis. The mddA gene is present in metagenomes from varied environments, being particularly abundant in soil environments, where it is predicted to occur in up to 76% of bacteria. This novel pathway may significantly contribute to global DMS emissions, especially in terrestrial environments, and could represent a shift from the notion that DMSP is the only significant precursor of DMS

Trauma history and depression predict incomplete adherence to antiretroviral therapies in a low income country.

As antiretroviral therapy (ART) for HIV becomes increasingly available in low and middle income countries (LMICs), understanding reasons for lack of adherence is critical to stemming the tide of infections and improving health. Understanding the effect of psychosocial experiences and mental health symptomatology on ART adherence can help maximize the benefit of expanded ART programs by indicating types of services, which could be offered in combination with HIV care. The Coping with HIV/AIDS in Tanzania (CHAT) study is a longitudinal cohort study in the Kilimanjaro Region that included randomly selected HIV-infected (HIV+) participants from two local hospital-based HIV clinics and four free-standing voluntary HIV counselling and testing sites. Baseline data were collected in 2008 and 2009; this paper used data from 36 month follow-up interviews (N = 468). Regression analyses were used to predict factors associated with incomplete self-reported adherence to ART. INCOMPLETE ART ADHERENCE WAS SIGNIFICANTLY MORE LIKELY TO BE REPORTED AMONGST PARTICIPANTS WHO EXPERIENCED A GREATER NUMBER OF CHILDHOOD TRAUMATIC EVENTS: sexual abuse prior to puberty and the death in childhood of an immediate family member not from suicide or homicide were significantly more likely in the non-adherent group and other negative childhood events trended toward being more likely. Those with incomplete adherence had higher depressive symptom severity and post-traumatic stress disorder (PTSD). In multivariable analyses, childhood trauma, depression, and financial sacrifice remained associated with incomplete adherence.\ud This is the first study to examine the effect of childhood trauma, depression and PTSD on HIV medication adherence in a low income country facing a significant burden of HIV. Allocating spending on HIV/AIDS toward integrating mental health services with HIV care is essential to the creation of systems that enhance medication adherence and maximize the potential of expanded antiretroviral access to improve health and reduce new infections

Genetic Improvement of Rice for Multiple Stress Tolerance in Unfavorable Rainfed Ecology

Not AvailableNot AvailableNot Availabl

Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy

We identified pyrvinium pamoate, an old anthelminthic medicine, which preferentially inhibits anchorage-independent growth of cancer cells over anchorage-dependent growth (∼10 fold). It was also reported by others to have anti-tumor activity in vivo and selective toxicity against cancer cells under glucose starvation in vitro, but with unknown mechanism. Here, we provide evidence that pyrvinium suppresses the transcriptional activation of GRP78 and GRP94 induced by glucose deprivation or 2-deoxyglucose (2DG, a glycolysis inhibitor), but not by tunicamycin or A23187. Other UPR pathways induced by glucose starvation, e.g. XBP-1, ATF4, were also found suppressed by pyrvinium. Constitutive expression of GRP78 via transgene partially protected cells from pyrvinium induced cell death under glucose starvation, suggesting that suppression of the UPR is involved in pyrvinium mediated cytotoxicity under glucose starvation. Xenograft experiments showed rather marginal overall anti-tumor activity for pyrvinium as a monotherapy. However, the combination of pyrvinium and Doxorubicin demonstrated significantly enhanced efficacy in vivo, supporting a mechanistic treatment concept based on tumor hypoglycemia and UPR

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.

Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity. The recruitment of innate leukocytes has been well studied in the context of extracellular bacterial and fungal infection but less during viral infections. We have recently shown that the understudied cytokine Interleukin (IL)-17D can mediate neutrophil, natural killer (NK) cell and monocyte infiltration in sterile inflammation and cancer. Herein, we show that early immune cell accumulation at the peritoneal site of infection by mouse cytomegalovirus (MCMV) is mediated by IL-17D. Mice deficient in IL-17D or the transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of IL-17D, featured an early decreased number of innate immune cells at the point of viral entry and were more susceptible to MCMV infection. Interestingly, we were able to artificially induce innate leukocyte infiltration by applying the Nrf2 activator tert-butylhydroquinone (tBHQ), which rendered mice less susceptible to MCMV infection. Our results implicate the Nrf2/IL-17D axis as a sensor of viral infection and suggest therapeutic benefit in boosting this pathway to promote innate antiviral responses