252 research outputs found

    Metabolic oscillations on the circadian time scale in <i>Drosophila</i> cells lacking clock genes.

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    Circadian rhythms are cell-autonomous biological oscillations with a period of about 24 h. Current models propose that transcriptional feedback loops are the primary mechanism for the generation of circadian oscillations. Within this framework, &lt;i&gt;Drosophila&lt;/i&gt; S2 cells are regarded as "non-rhythmic" cells, as they do not express several canonical circadian components. Using an unbiased multi-omics approach, we made the surprising discovery that &lt;i&gt;Drosophila&lt;/i&gt; S2 cells do in fact display widespread daily rhythms. Transcriptomics and proteomics analyses revealed that hundreds of genes and their products, and in particular metabolic enzymes, are rhythmically expressed in a 24-h cycle. Metabolomics analyses extended these findings and demonstrate that central carbon metabolism and amino acid metabolism are core metabolic pathways driven by protein rhythms. We thus demonstrate that 24-h metabolic oscillations, coupled to gene and protein cycles, take place in nucleated cells without the contribution of any known circadian regulators. These results therefore suggest a reconsideration of existing models of the clockwork in &lt;i&gt;Drosophila&lt;/i&gt; and other eukaryotic systems

    Primordialists and Constructionists: a typology of theories of religion

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    This article adopts categories from nationalism theory to classify theories of religion. Primordialist explanations are grounded in evolutionary psychology and emphasize the innate human demand for religion. Primordialists predict that religion does not decline in the modern era but will endure in perpetuity. Constructionist theories argue that religious demand is a human construct. Modernity initially energizes religion, but subsequently undermines it. Unpacking these ideal types is necessary in order to describe actual theorists of religion. Three distinctions within primordialism and constructionism are relevant. Namely those distinguishing: a) materialist from symbolist forms of constructionism; b) theories of origins from those pertaining to the reproduction of religion; and c) within reproduction, between theories of religious persistence and secularization. This typology helps to make sense of theories of religion by classifying them on the basis of their causal mechanisms, chronology and effects. In so doing, it opens up new sightlines for theory and research

    Statefinder Parameters for Different Dark Energy Models with Variable G Correction in Kaluza-Klein Cosmology

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    In this work, we have calculated the deceleration parameter, statefinder parameters and EoS parameters for different dark energy models with variable GG correction in homogeneous, isotropic and non-flat universe for Kaluza-Klein Cosmology. The statefinder parameters have been obtained in terms of some observable parameters like dimensionless density parameter, EoS parameter and Hubble parameter for holographic dark energy, new agegraphic dark energy and generalized Chaplygin gas models.Comment: 9 pages, no figure, accepted for publication in IJTP. arXiv admin note: text overlap with arXiv:1104.2366 by other author

    Abundances of the elements in the solar system

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    A review of the abundances and condensation temperatures of the elements and their nuclides in the solar nebula and in chondritic meteorites. Abundances of the elements in some neighboring stars are also discussed.Comment: 42 pages, 11 tables, 8 figures, chapter, In Landolt- B\"ornstein, New Series, Vol. VI/4B, Chap. 4.4, J.E. Tr\"umper (ed.), Berlin, Heidelberg, New York: Springer-Verlag, p. 560-63

    Guidelines and Recommendations on the Use of Higher OrderFinite Elements for Bending Analysis of Plates

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    This paper compares and evaluates various plate finite elements to analyse the static response of thick and thin plates subjected to different loading and boundary conditions. Plate elements are based on different assumptions for the displacement distribution along the thickness direction. Classical (Kirchhoff and Reissner-Mindlin), refined (Reddy and Kant), and other higher-order displacement fields are implemented up to fourth-order expansion. The Unified Formulation UF by the first author is used to derive finite element matrices in terms of fundamental nuclei which consist of 3 × 3 arrays. The MITC4 shear-locking free type formulation is used for the FE approximation. Accuracy of a given plate element is established in terms of the error vs. thickness-to-length parameter. A significant number of finite elements for plates are implemented and compared using displacement and stress variables for various plate problems. Reduced models that are able to detect the 3D solution are built and a Best Plate Diagram (BPD) is introduced to give guidelines for the construction of plate theories based on a given accuracy and number of terms. It is concluded that the UF is a valuable tool to establish, for a given plate problem, the most accurate FE able to furnish results within a certain accuracy range. This allows us to obtain guidelines and recommendations in building refined elements in the bending analysis of plates for various geometries, loadings, and boundary conditions

    Magnetism in Dense Quark Matter

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    We review the mechanisms via which an external magnetic field can affect the ground state of cold and dense quark matter. In the absence of a magnetic field, at asymptotically high densities, cold quark matter is in the Color-Flavor-Locked (CFL) phase of color superconductivity characterized by three scales: the superconducting gap, the gluon Meissner mass, and the baryonic chemical potential. When an applied magnetic field becomes comparable with each of these scales, new phases and/or condensates may emerge. They include the magnetic CFL (MCFL) phase that becomes relevant for fields of the order of the gap scale; the paramagnetic CFL, important when the field is of the order of the Meissner mass, and a spin-one condensate associated to the magnetic moment of the Cooper pairs, significant at fields of the order of the chemical potential. We discuss the equation of state (EoS) of MCFL matter for a large range of field values and consider possible applications of the magnetic effects on dense quark matter to the astrophysics of compact stars.Comment: To appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye
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