682 research outputs found
Variational Geometric Approach To Generalized Differential And Conjugate Calculi In Convex Analysis
This paper develops a geometric approach of variational analysis for the case of convex objects considered in locally convex topological spaces and also in Banach space settings. Besides deriving in this way new results of convex calculus, we present an overview of some known achievements with their unified and simplified proofs based on the developed geometric variational schemes. Key words. Convex and variational analysis, Fenchel conjugates, normals and subgradients, coderivatives, convex calculus, optimal value functions
Variable Star Candidates in an ACS Field of M31
A search for variable stars is performed using two epochs of Hubble Space
Telescope (HST) Advanced Camera for Surveys (ACS) imaging data for a 9.28
square arcminute portion of M31. This data set reveals 254 sources that vary by
at least 4-sigma between epochs. The positions and 2-epoch B-band (equivalent)
photometry of these sources are presented. The photometry suggests that this
catalog includes most of the RR Lyrae population of this portion of M31.Comment: 22 pages, 3 tables, 5 figures, accepted for publication in A
Entry in the ADHD drugs market: Welfare impact of generics and me-toos
Recent decades have seen a growth in treatments for attention deficit hyperactivity disorder (ADHD) including many branded and generic drugs. In the early 2000's, new drug entry dramatically altered market shares. We estimate a demand system for ADHD drugs and assess the welfare impact of new drugs. We find that entry induced large welfare gains by reducing prices of substitute drugs, and by providing alternative delivery mechanisms for existing molecules. Our results suggest that the success of follow-on patented drugs may come from unanticipated innovations like delivery mechanisms, a factor ignored by proposals to retard new follow-on drug approvals
Mg/Ti multilayers: structural, optical and hydrogen absorption properties
Mg-Ti alloys have uncommon optical and hydrogen absorbing properties,
originating from a "spinodal-like" microstructure with a small degree of
chemical short-range order in the atoms distribution. In the present study we
artificially engineer short-range order by depositing Pd-capped Mg/Ti
multilayers with different periodicities and characterize them both
structurally and optically. Notwithstanding the large lattice parameter
mismatch between Mg and Ti, the as-deposited metallic multilayers show good
structural coherence. Upon exposure to H2 gas a two-step hydrogenation process
occurs, with the Ti layers forming the hydride before Mg. From in-situ
measurements of the bilayer thickness L at different hydrogen pressures, we
observe large out-of-plane expansions of the Mg and Ti layers upon
hydrogenation, indicating strong plastic deformations in the films and a
consequent shortening of the coherence length. Upon unloading at room
temperature in air, hydrogen atoms remain trapped in the Ti layers due to
kinetic constraints. Such loading/unloading sequence can be explained in terms
of the different thermodynamic properties of hydrogen in Mg and Ti, as shown by
diffusion calculations on a model multilayered systems. Absorption isotherms
measured by hydrogenography can be interpreted as a result of the elastic
clamping arising from strongly bonded Mg/Pd and broken Mg/Ti interfaces
Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology
<p>Abstract</p> <p>Background</p> <p>Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity and robustness. The richness in bio-ontologies is a prior condition for diverse and efficient reasoning, and hence querying and hypothesis validation. Rigour allows a more consistent maintenance. Modelling such bio-ontologies is, however, a difficult task for bio-ontologists, because the necessary richness and rigour is difficult to achieve without extensive training.</p> <p>Results</p> <p>Analogous to design patterns in software engineering, Ontology Design Patterns are solutions to typical modelling problems that bio-ontologists can use when building bio-ontologies. They offer a means of creating rich and rigorous bio-ontologies with reduced effort. The concept of Ontology Design Patterns is described and documentation and application methodologies for Ontology Design Patterns are presented. Some real-world use cases of Ontology Design Patterns are provided and tested in the Cell Cycle Ontology. Ontology Design Patterns, including those tested in the Cell Cycle Ontology, can be explored in the Ontology Design Patterns public catalogue that has been created based on the documentation system presented (<url>http://odps.sourceforge.net/</url>).</p> <p>Conclusions</p> <p>Ontology Design Patterns provide a method for rich and rigorous modelling in bio-ontologies. They also offer advantages at different development levels (such as design, implementation and communication) enabling, if used, a more modular, well-founded and richer representation of the biological knowledge. This representation will produce a more efficient knowledge management in the long term.</p
e-Science and biological pathway semantics
<p>Abstract</p> <p>Background</p> <p>The development of e-Science presents a major set of opportunities and challenges for the future progress of biological and life scientific research. Major new tools are required and corresponding demands are placed on the high-throughput data generated and used in these processes. Nowhere is the demand greater than in the semantic integration of these data. Semantic Web tools and technologies afford the chance to achieve this semantic integration. Since pathway knowledge is central to much of the scientific research today it is a good test-bed for semantic integration. Within the context of biological pathways, the BioPAX initiative, part of a broader movement towards the standardization and integration of life science databases, forms a necessary prerequisite for its successful application of e-Science in health care and life science research. This paper examines whether BioPAX, an effort to overcome the barrier of disparate and heterogeneous pathway data sources, addresses the needs of e-Science.</p> <p>Results</p> <p>We demonstrate how BioPAX pathway data can be used to ask and answer some useful biological questions. We find that BioPAX comes close to meeting a broad range of e-Science needs, but certain semantic weaknesses mean that these goals are missed. We make a series of recommendations for re-modeling some aspects of BioPAX to better meet these needs.</p> <p>Conclusion</p> <p>Once these semantic weaknesses are addressed, it will be possible to integrate pathway information in a manner that would be useful in e-Science.</p
Clinical decision support using Open Data
First Online: 18 May 2020.The growth of Electronical Health Records (EHR) in healthcare has been gradual. However, a simple EHR system has become inefficient in supporting health professionals on decision making. In this sense, the need to acquire knowledge from storing data using open models and techniques has emerged, for the sake of improving the quality of service provided and to support the decision-making process. The usage of open models promotes interoperability between systems, communicating more efficiently. In this sense, the OpenEHR open data approach is applied, modelling data in two levels to distinguish knowledge from information. The application of clinical terminologies was fundamental in this study, in order to control data semantics based on coded clinical terms. This article culminated from the conceptualization of the knowledge acquisition process to represent Clinical Decision Support, using open data models.The work has been supported by FCT–Fundação para a Ciência e Tec-nologia within the Project Scope UID/CEC/00319/2019 and DSAIPA/DS/0084/2018
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Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF
Chandra Observations of 3C Radio Sources with z<0.3: Nuclei, Diffuse Emission, Jets and Hotspots
We report on our Chandra Cycle 9 program to observe half of the 60
(unobserved by Chandra) 3C radio sources at z<0.3 for 8 ksec each. Here we give
the basic data: the X-ray intensity of the nuclei and any features associated
with radio structures such as hot spots and knots in jets. We have measured
fluxes in soft, medium and hard bands and are thus able to isolate sources with
significant intrinsic column density. For the stronger nuclei, we have applied
the standard spectral analysis which provides the best fit values of X-ray
spectral index and column density. We find evidence for intrinsic absorption
exceeding a column density of 10^{22} cm^{-2} for one third of our sources.Comment: 12 pages, 37 figures (the complete version of the paper with all
figures is available on line, see appendix for details), ApJ accepte
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