Sustained Positive Effects on Graduation Rates Produced by New York City's Small Public High Schools of Choice

Evaluates how effectively small academically nonselective high schools that replaced large failing ones achieved sustained improvement in academic progress and graduation rates across variations in prior proficiency, family income, and demographics

The Evaluation of Enhanced Academic Instruction in After-School Programs: Findings After the First Year of Implementation

This report presents one-year implementation and impact findings on two supplemental academic instruction approaches developed for after-school settings -- one for math and one for reading. Compared with regular after-school programming, the supplemental math program had impacts on student SAT 10 test scores and the supplemental reading program did not --although the reading program had some effect on reading fluency

The Effects of Enrolling in Oversubscribed Prekindergarten Programs Through Third Grade

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162748/2/cdev13308_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162748/1/cdev13308.pd

Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway

Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mechanisms linking alterations in insulin signaling with plasma lipoprotein metabolism are incompletely understood. The insulin-repressible FoxO transcription factors mediate key effects of hepatic insulin action on glucose and lipoprotein metabolism. This work tested whether hepatic insulin signaling regulates HDL-S1P and aimed to identify the underlying molecular mechanisms. We report that insulin-resistant, nondiabetic individuals had decreased HDL-S1P levels, but no change in total plasma S1P. This also occurred in insulin-resistant db/db mice, which had low ApoM and a specific reduction of S1P in the HDL fraction, with no change in total plasma S1P levels. Using mice lacking hepatic FoxOs (L-FoxO1,3,4), we found that hepatic FoxOs were required for ApoM expression. Total plasma S1P levels were similar to those in controls, but S1P was nearly absent from HDL and was instead increased in the lipoprotein-depleted plasma fraction. This phenotype was restored to normal by rescuing ApoM in L-FoxO1,3,4 mice. Our findings show that insulin resistance in humans and mice is associated with decreased HDL-associated S1P. Our study shows that hepatic FoxO transcription factors are regulators of the ApoM/S1P pathway

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

Foxa2 (HNF3β) is a one of three, closely related transcription factors that are critical to the development and function of the mouse liver. We have used chromatin immunoprecipitation and massively parallel Illumina 1G sequencing (ChIP–Seq) to create a genome-wide profile of in vivo Foxa2-binding sites in the adult liver. More than 65% of the ∼11.5 k genomic sites associated with Foxa2 binding, mapped to extended gene regions of annotated genes, while more than 30% of intragenic sites were located within first introns. 20.5% of all sites were further than 50 kb from any annotated gene, suggesting an association with novel gene regions. QPCR analysis demonstrated a strong positive correlation between peak height and fold enrichment for Foxa2-binding sites. We measured the relationship between Foxa2 and liver gene expression by overlapping Foxa2-binding sites with a SAGE transcriptome profile, and found that 43.5% of genes expressed in the liver were also associated with Foxa2 binding. We also identified potential Foxa2-interacting transcription factors whose motifs were enriched near Foxa2-binding sites. Our comprehensive results for in vivo Foxa2-binding sites in the mouse liver will contribute to resolving transcriptional regulatory networks that are important for adult liver function

The Kindergarten Hotspot: Literacy Skill Convergence Between Boston Prekindergarten Enrollees and Nonenrollees

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167052/1/cdev13499_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167052/2/cdev13499.pd

Transforming the High School Experience: How New York City's New Small Schools Are Boosting Student Achievement and Graduation Rates

Evaluates how a system of small, academically non-selective high schools emphasizing academic rigor, student-teacher relationships, and community partnerships improved achievement and graduation rates for disadvantaged students. Explores implications