Ammengebundene Kälberaufzucht in der Milchkuhhaltung: Unterschiede zwischen an der Mutter oder einer Amme aufgezogenen Kälbern bezüglich Mortalität und Absetzgewicht auf einem Praxisbetrieb

Wir untersuchten ein System, bei dem Ammenkälber zusammen mit dem eigenen Kalb der Kuh gesäugt wurden. Es wurden Unterschiede in der Mortalität und der Gewichtsentwicklung zwischen eigenen Kälbern und Ammenkälbern untersucht. Es wurde kein signifikanter Einfluss der Art der Aufzucht festgestellt

Defining a recovery-oriented cascade of care for opioid use disorder: A community-driven, statewide cross-sectional assessment

Background In light of the accelerating and rapidly evolving overdose crisis in the United States (US), new strategies are needed to address the epidemic and to efficiently engage and retain individuals in care for opioid use disorder (OUD). Moreover, there is an increasing need for novel approaches to using health data to identify gaps in the cascade of care for persons with OUD. Methods and findings Between June 2018 and May 2019, we engaged a diverse stakeholder group (including directors of statewide health and social service agencies) to develop a statewide, patient-centered cascade of care for OUD for Rhode Island, a small state in New England, a region highly impacted by the opioid crisis. Through an iterative process, we modified the cascade of care defined by Williams et al. for use in Rhode Island using key national survey data and statewide health claims datasets to create a cross-sectional summary of 5 stages in the cascade. Approximately 47,000 Rhode Islanders (5.2%) were estimated to be at risk for OUD (stage 0) in 2016. At the same time, 26,000 Rhode Islanders had a medical claim related to an OUD diagnosis, accounting for 55% of the population at risk (stage 1); 27% of the stage 0 population, 12,700 people, showed evidence of initiation of medication for OUD (MOUD, stage 2), and 18%, or 8,300 people, had evidence of retention on MOUD (stage 3). Imputation from a national survey estimated that 4,200 Rhode Islanders were in recovery from OUD as of 2016, representing 9% of the total population at risk. Limitations included use of self-report data to arrive at estimates of the number of individuals at risk for OUD and using a national estimate to identify the number of individuals in recovery due to a lack of available state data sources. Conclusions Our findings indicate that cross-sectional summaries of the cascade of care for OUD can be used as a health policy tool to identify gaps in care, inform data-driven policy decisions, set benchmarks for quality, and improve health outcomes for persons with OUD. There exists a significant opportunity to increase engagement prior to the initiation of OUD treatment (i.e., identification of OUD symptoms via routine screening or acute presentation) and improve retention and remission from OUD symptoms through improved community-supported processes of recovery. To do this more precisely, states should work to systematically collect data to populate their own cascade of care as a health policy tool to enhance system-level interventions and maximize engagement in care

Varieties of linguistic complexity in a standardized assessment of language performance

This study examined the comprehension of linguistically complex sentences among unimpaired adults and adults with aphasia. Participants completed a self-paced reading version of the Computerized Revised Token Test (CRTT-R) containing passive sentences, sentences with adverbial clauses, and sentences with discontinuous adjective-noun dependencies. Off-line measures revealed clear effects of linguistic complexity for passive and discontinuous-dependency sentences, with more complex sentences eliciting lower scores for impaired and aphasic groups, but not for sentences with adverbial clauses. In contrast, on-line measures revealed the opposite pattern: less complex sentences elicited slower reading times. Off-line measures appear more sensitive to linguistic complexity in this task

The Molecular ISM in the Super Star Clusters of the Starburst NGC 253

We present submillimeter spectra of the (proto-)super star cluster (SSC) candidates in the starbursting center of the nearby galaxy NGC 253 identified by Leroy et al. (2018). The 2.5pc resolution of our ALMA cycle 3 observations approach the size of the SSCs and allows the study of physical and chemical properties of the molecular gas in these sources. In the 14 SSC sources and in the frequency ranges 342.0-345.8 GHz and 353.9-357.7 GHz we detect 55 lines belonging to 19 different chemical species. The SSCs differ significantly in chemical complexity, with the richest clusters showing 19 species and the least complex showing 4 species. We detect HCN isotopologues and isomers (H$^{13}$CN, HC$^{15}$N, H$^{15}$NC), abundant HC$_3$N, SO and S$^{18}$O, SO$_2$, and H$_2$CS. The gas ratios CO/HCN, CO/HCO$^+$ are low, ~1-10, implying high dense gas fractions in the SSCs. Line ratio analyses suggests chemistry consistent with photon-dominated regions and mechanical heating. None of the SSCs near the galaxy center show line ratios that imply an X-ray dominated region, suggesting that heating by any (still unknown) AGN does not play a major role. The gas temperatures are high in most sources, with an average rotational temperature of ~130 K in SO$_2$. The widespread existence of vibrationally excited HCN and HC$_3$N transitions implies strong IR radiation fields, potentially trapped by a greenhouse effect due to high continuum opacities.Comment: 20 pages, 4 figures, 6 tables; accepted for publication in the Astrophysical Journa

The Molecular Outflow in NGC 253 at a Resolution of Two Parsecs

We present 0.'' 15 (similar to 2.5 pc) resolution ALMA CO(3-2) observations of the starbursting center in NGC 253. Together with archival ALMA CO(1-0) and CO(2-1) data, we decompose the emission into disk and nondisk components. We find similar to 7%-16% of the CO luminosity to be associated with the nondisk component (1.2-4.2 x 10(7) K km s(-1) pc(2)). The total molecular gas mass in the center of NGC 253 is similar to 3.6 x 10(8) M-circle dot with similar to 0.5 x 10(8) M-circle dot (similar to 15%) in the nondisk component. These measurements are consistent across independent mass estimates through three CO transitions. The high-resolution CO(3-2) observations allow us to identify the molecular outflow within the nondisk gas. Using a starburst conversion factor, we estimate the deprojected molecular mass outflow rate, kinetic energy, and momentum in the starburst of NGC 253. The deprojected molecular mass outflow rate is in the range of similar to 14-39 M-circle dot yr(-1) with an uncertainty of 0.4 dex. The large spread arises due to different interpretations of the kinematics of the observed gas while the errors are due to unknown geometry. The majority of this outflow rate is contributed by distinct outflows perpendicular to the disk, with a significant contribution by diffuse molecular gas. This results in a mass-loading factor eta = (M) over dot(out)/(M) over dot(SFR) in the range eta similar to 8-20 for gas ejected out to similar to 300 pc. We find the kinetic energy of the outflow to be similar to 2.5-4.5 x 10(54) erg and a typical error of similar to 0.8 dex, which is similar to 0.1% of the total or similar to 8% of the kinetic energy supplied by the starburst. The outflow momentum is 4.8-8.7 x 10(8) M-circle dot km s(-1) (similar to 0.5 dex error) or similar to 2.5%-4% of the kinetic momentum released into the ISM by the feedback. The unknown outflow geometry and launching sites are the primary sources of uncertainty in this study.Peer reviewe

QTL and candidate gene mapping for polyphenolic composition in apple fruit

<p>Abstract</p> <p>Background</p> <p>The polyphenolic products of the phenylpropanoid pathway, including proanthocyanidins, anthocyanins and flavonols, possess antioxidant properties that may provide health benefits. To investigate the genetic architecture of control of their biosynthesis in apple fruit, various polyphenolic compounds were quantified in progeny from a 'Royal Gala' × 'Braeburn' apple population segregating for antioxidant content, using ultra high performance liquid chromatography of extracts derived from fruit cortex and skin.</p> <p>Results</p> <p>Construction of genetic maps for 'Royal Gala' and 'Braeburn' enabled detection of 79 quantitative trait loci (QTL) for content of 17 fruit polyphenolic compounds. Seven QTL clusters were stable across two years of harvest and included QTLs for content of flavanols, flavonols, anthocyanins and hydroxycinnamic acids. Alignment of the parental genetic maps with the apple whole genome sequence <it>in silico </it>enabled screening for co-segregation with the QTLs of a range of candidate genes coding for enzymes in the polyphenolic biosynthetic pathway. This co-location was confirmed by genetic mapping of markers derived from the gene sequences. <it>Leucoanthocyanidin reductase </it>(<it>LAR1</it>) co-located with a QTL cluster for the fruit flavanols catechin, epicatechin, procyanidin dimer and five unknown procyanidin oligomers identified near the top of linkage group (LG) 16, while <it>hydroxy cinnamate/quinate transferase </it>(<it>HCT</it>/<it>HQT</it>) co-located with a QTL for chlorogenic acid concentration mapping near the bottom of LG 17.</p> <p>Conclusion</p> <p>We conclude that <it>LAR1 </it>and <it>HCT</it>/<it>HQT </it>are likely to influence the concentration of these compounds in apple fruit and provide useful allele-specific markers for marker assisted selection of trees bearing fruit with healthy attributes.</p

Factors that facilitate consumer uptake of sustainable dietary patterns in Western countries: a scoping review

ObjectivesThis scoping review aims to describe factors that facilitate consumer-level transitions to more environmentally sustainable diets.MethodsUsing scoping review methods, four databases were searched for articles published in English examining facilitators to consuming an environmentally sustainable diet and focused on consumers, using data collected in Western countries, and were published between 2012 and 2022. Researchers extracted study characteristics and factors influencing adoption or uptake of sustainable foods or dietary patterns. Using this data, researchers conducted a thematic analysis to determine five main themes describing leverage points (modifiable) for dietary transitions.ResultsResults are reported per PRISMA guidelines: 21 studies were included with data from the U.K., U.S., Australia, and Europe. The results of this review indicate that values, knowledge, marketing, consumer-product relationships, and support networks, along with their respective subthemes, may be central drivers of consumer adoption of sustainable dietary patterns. Consumers are more likely to purchase and consume products which are familiar and appealing and align with their values. Cost, lack of knowledge, and lack of social support act as barriers to dietary change to more sustainable food choices. Income, education, ethnicity, sex, and employment were common individual-level characteristics identified as influential over likelihood of adopting environmentally sustainable dietary patterns. Individual-level characteristics create nuances in both likelihood to adopt, and the experience of barriers to adopting, sustainable dietary patterns.ConclusionKnowledge of leverage points and individual-level nuances is useful in informing strategies to facilitate transitions to more sustainable diets

Forming Super Star Clusters in the Central Starburst of NGC 253

NGC 253 hosts the nearest nuclear starburst. Previous observations show a region rich in molecular gas, with dense clouds associated with recent star formation. We used the Atacama Large Submillimeter/Millimeter Array (ALMA) to image the 350 GHz dust continuum and molecular line emission from this region at 2 pc resolution. Our observations reveal similar to 14 bright, compact (similar to 2-3 pc FWHM) knots of dust emission. Most of these sources are likely to be forming super star clusters (SSCs) based on their inferred dynamical and gas masses, association with 36 GHz radio continuum emission, and coincidence with line emission tracing dense, excited gas. One source coincides with a known SSC, but the rest remain invisible in Hubble near-infrared (IR) imaging. Our observations imply that gas still constitutes a large fraction of the overall mass in these sources. Their high brightness temperature at 350 GHz also implies a large optical depth near the peak of the IR spectral energy distribution. As a result, these sources may have large IR photospheres, and the IR radiation force likely exceeds L/c. Still, their moderate observed velocity dispersions suggest that feedback from radiation, winds, and supernovae are not yet disrupting most sources. This mode of star formation appears to produce a large fraction of stars in the burst. We argue for a scenario in which this phase lasts similar to 1 Myr, after which the clusters shed their natal cocoons but continue to produce ionizing photons. The strong feedback that drives the observed cold gas and X-ray outflows likely occurs after the clusters emerge from this early phase.Peer reviewe

The turbulent gas structure in the centers of NGC253 and the Milky Way

We compare molecular gas properties in the starbursting center of NGC253 and the Milky Way Galactic Center (GC) on scales of ~1-100 pc using dendograms and resolution-, area- and noise-matched datasets in CO (1-0) and CO (3-2). We find that the size-line width relations in NGC253 and the GC have similar slope, but NGC253 has larger line widths by factors of ~2-3. The $\sigma^2/R$ dependency on column density shows that, in the GC, on scales of 10-100 pc the kinematics of gas over $N>3\times10^{21}$ cm$^{-2}$ are compatible with gravitationally bound structures. In NGC253 this is only the case for column densities $N>3\times10^{22}$ cm$^{-2}$. The increased line widths in NGC253 originate in the lower column density gas. This high-velocity dispersion, not gravitationally self-bound gas is likely in transient structures created by the combination of high average densities and feedback in the starburst. The high densities turns the gas molecular throughout the volume of the starburst, and the injection of energy and momentum by feedback significantly increases the velocity dispersion at a given spatial scale over what is observed in the GC.Comment: 13 pages, 3 figures, 4 tables; accepted for publication in the Astrophysical Journa