Sexual harassment cases increasingly prosecuted

Sexual harassment isn\u27t about morality and sex, it\u27s about discrimination, said Sue Estler, director of the Equal Opportunity Office. The University of Maine has a policy prohibiting sexual harassment and there have been increasing numbers of such cases reported since they were first recorded

Witness\u27 accounts of altercation differ

Statements given by Quester Hannah, Aaron Phillips and others involved in the fight on February 17 in Orono give differing versions of the incident, but in the words of District Attorney Chris Almy, that\u27s why we go to court

Space Science 101 - Materials Science & Biophysics

No abstract availabl

GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo

Photofootprinting in vivo of GALl reveals an activation- dependent pattern between the UASG and the TATA box, in a sequence not required for transcriptional activation by GAL4. The pattern results from a nucleosome whose position depends on sequences within the UASG. In the wild-type gene, activation by GAL4 and derivatives disrupts this nucleosome. This activity is independent of interactions with DNA-bound core transcription factors and is proportional to the strength of the activator. Presence of the nucleosome correlates with low basal transcription levels under various conditions, suggesting a role in limiting basal expression. We propose a role for the GAL4 activation domain in displacing a nucleosome and suggest that this is part of the mechanism by which GAL4 activates transcription in vivo

Characterization of a mutant strain of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

We have constructed a strain of Saccharomyces cerevisiae with a deletion of the YKL510 open reading frame, which was initially identified in chromosome XI as a homolog of the RAD2 nucleotide excision repair gene (A. Jacquier, P. Legrain, and B. Dujon, Yeast 8:121–132, 1992). The mutant strain exhibits increased sensitivity to UV light and to the alkylating agent methylmethane sulfonate but not to ionizing radiation. We have renamed the YKL510 open reading frame the RAD27 gene, in keeping with the accepted nomenclature for radiationsensitive yeast mutants. Epistasis analysis indicates that the gene is in the RAD6 group of genes, which are involved in DNA damage tolerance. The mutant strain also exhibits increased plasmid loss, increased spontaneous mutagenesis, and a temperature-sensitive lethality whose phenotype suggests a defect in DNA replication. Levels of the RAD27 gene transcript are cell cycle regulated in a manner similar to those for several other genes whose products are known to be involved in DNA replication. We discuss the possible role of Rad27 protein in DNA repair and replication