40 research outputs found
Methods of Preparation of Aromatic Anils
The aim of this study is to to prepare and identify and characterize the aromatic anils (Schiff.s bases or benzylidene aniline) then used for kinetic study that is cooxidation in presence of oxalic acid by chromic acid in acetic acid medium
Cholest-5-en-3β-yl N-phenylcarbamate
In the title compound, C34H51NO2, the dihedral angle between the planes of the phenyl ring and the carbonyl group is 9.30 (2)°. No significant intermolecular interactions are observed in the crystal structure. The C5H11 fragment is disordered over two positions with site occupancies of 0.611 (6) and 0.389 (6)
7,7′,8,8′-Tetramethoxy-4,4′-dimethyl-3,3′-bicoumarin
In the crystal structure, the title compound, C24H22O8, lies on a twofold rotation axis and the asymmetric unit comprises one half-molecule. The dihedral angle formed by the coumarin unit with the symmetry-related part is 74.78 (14)°. One of the methoxy groups attached to the coumarin unit is considerably twisted, making an angle of 87.17 (17)° with respect to the coumarin unit; the other is twisted by 0.66 (19)°. No classical hydrogen bonds are found in the sturcture; only a weak C—H⋯π interaction and short intramolecular O⋯O contacts [2.683 (2)–2.701 (2) Å] are observed
Cyclohexane-1,3-diyl bis(N-phenylcarbamate)
The asymmetric unit of the title compound, C20H22N2O4, comprises two crystallographically independent molecules (A and B) with slightly different geometries. The dihedral angle between the two terminal phenyl rings is 61.7 (1)° in molecule A and 29.6 (1)° in B. The cyclohexane rings adopt chair conformations. In the crystal packing, intermolecular N—H⋯O hydrogen bonds interconnect adjacent molecules into a ladder-like structure along the c axis incorporating R
2
2(20) ring motifs. The crystal packing is further stabilized by weak intermolecular C—H⋯π interactions
A novel antimicrobial triterpenic acid from the leaves of Ficus benjamina (var. comosa)
AbstractThe chloroform extract of the leaves of Ficus benjamina (var. comosa) (Moraceae) afforded a new triterpenic acid named as (9,11), (18,19)-disecoolean-12-en-28-oic acid (1) along with β-amyrin (2). Their structures were established on the basis of chemical and physical evidences (IR, 1H NMR, and MS data). The compound 1 exhibited significant antimicrobial activity against Salmonella typhimurium (MTCC-98), Candida albicans (IAO-109), Staphylococcus aureus (IAO-SA-22), Escherichia coli (K-12) and low activity against Aspergillus niger (lab isolate ICAR) and Aspergillus brassicola
9-(3,4-Dimethoxyphenyl)-3,4,5,6,7,9-hexahydroxanthene-1,8(2H)-dione
In the title compound, C21H22O5, the mean planes of the pyran and dimethoxyphenyl rings are nearly perpendicular to one another, with the dihedral angle between them being 88.21 (8)°. The pyran ring adopts a boat conformation whereas the two fused cyclohexane rings adopt envelope conformations. In the crystal, molecules are linked into a three-dimensional network by intermolecular C—H⋯O hydrogen bonds
Redetermination of ethyl (3a-cis)-3a,8b-dihydroxy-2-methyl-4-oxo-3a,8b-dihydro-4H-indeno[1,2-b]furan-3-carboxylate monohydrate
The crystal structure of the title compound, C15H14O6·H2O, has been redetermined from single-crystal X-ray data. The structure was originally determined by Peet et al. [J. Heterocycl. Chem. (1995), 32, 33–41] but the atomic coordinates were not reported or deposited in the Cambridge Structural Database. The ethyl substituent is disordered over two sites with refined occupancies of 0.815 (6) and 0.185 (6). The indeno group is almost planar [maximum deviation 0.0922 (14) Å] and makes an angle of 68.81 (4)° with the furan ring. The fused ring molecules are assembled in pairs by intermolecular O—H⋯O hydrogen bonds. The resulting dimers are also hydrogen bonded to the water molecules, forming double-stranded chains running along the a axis
SYNTHESIS, CHARACTERIZATIONAND ANTIMICROBIALACTIVITYOF FRIEDELIN [2, 3-d] SElENADIAZOlE
ABSTRACT
The new 1, 2, 3, selenadiazole derivative (3) was prepared from friedelin (1) via the co"esponding
semicarbazone (2) using Lalezari cyclization. The compounds were prepared, separated and characterized on the
basis of microanalysis and spectral studies. The isolated friedelin and its selenadiazole were screened in vitro for
their antimicrobial activities against various pathogenic bacterial were found to be highly active against al/ the
selected pathogens. Compound 3 showed an inhibition zone of 14 mm and 12 mm respectively against highly
resistant S. albus and C. albicans. A general mechanistic scheme for these reactions is also suggested based on
current and previous results
3-(2-Amino-5-nitroanilino)-5,5-dimethylcyclohex-2-en-1-one 0.25-hydrate
The asymmetric unit of the title compound, C14H17N3O3·0.25H2O, comprises two independent organic molecules and a water molecule lying on a crystallographic twofold rotation axis with 50% site occupancy. In both independent molecules, the cyclohexene rings adopt envelope conformations but superposition of the two molecules shows that the flap atoms point in opposite directions. In the crystal, N—H⋯O and C—H⋯O hydrogen bonds interconnect adjacent molecules into a three-dimensional network. Weak intermolecular π–π aromatic stacking interactions [centroid–centroid distances = 3.4985 (9) and 3.6630 (9) Å] are also observed
2,3-Dimethyl-6-nitroquinoxaline
The asymmetric unit of the title quinoxaline compound, C10H9N3O2, contains two crystallographically independent molecules (A and B). The quinoxaline ring systems are essentially planar, with maximum deviations of 0.006 (1) and 0.017 (1) Å, respectively, for molecules A and B. In molecule A, the dihedral angle formed between the quinoxaline ring system and nitro group is 10.94 (3)° [6.31 (13)° for molecule B]. In the crystal, molecules are linked into chains propagating along [001]: one forms zigzag chains linked by C—H⋯O hydrogen bonds, whilst the other forms ladder-like chains by way of C—H⋯N and C—H⋯O hydrogen bonds. The packing is further consolidated by weak π–π interactions [range of centroid–centroid distances = 3.5895 (7)–3.6324 (7) Å]