Global search for autumn‐lead sea surface salinity predictors of winter precipitation in southwestern United States

Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 45 (2018): 8445-8454, doi:10.1029/2018GL079293.Sea surface salinity (SSS) is sensitive to changes in ocean evaporation and precipitation, that is, to changes in the oceanic water cycle. Through the close connection between the oceanic and terrestrial water cycle, SSS can be used as an indicator of rainfall on land. Here we search globally for teleconnections between autumn‐lead September‐October‐November SSS signals and winter December‐January‐February precipitation over southwestern United States. The SSS‐based model (R2 = 0.61) outperforms the sea surface temperature‐based model (R2 = 0.54). Further, a fresh tropical Pacific in autumn, indicated by low SSS, corresponds with wet winters. Recent studies suggest that anomalously high rainfall in the tropics may excite Rossby waves that can export water to the extratropics. Thus, incorporating SSS, a sensitive indicator of regional oceanic rainfall, can enhance the accuracy of existing precipitation prediction frameworks that rely on sea surface temperature‐based climate indices and, by extension, improve watershed management.NSF Grant Numbers: ICER‐1663704, ICER‐1663138, DGE1144152, DGE1745303; Woods Hole Oceanographic Institution2019-02-2

How patients think about social responsibility of public hospitals in China?

Questionnaire for the patients of public hospitals. The questionnaire was designed and implemented in the survey to understand patients’ opinion of the medical services, especially the view of social responsibility of this public hospital. (DOC 32 kb

Weakly Secure Symmetric Multilevel Diversity Coding

Multilevel diversity coding is a classical coding model where multiple mutually independent information messages are encoded, such that different reliability requirements can be afforded to different messages. It is well known that {\em superposition coding}, namely separately encoding the independent messages, is optimal for symmetric multilevel diversity coding (SMDC) (Yeung-Zhang 1999). In the current paper, we consider weakly secure SMDC where security constraints are injected on each individual message, and provide a complete characterization of the conditions under which superposition coding is sum-rate optimal. Two joint coding strategies, which lead to rate savings compared to superposition coding, are proposed, where some coding components for one message can be used as the encryption key for another. By applying different variants of Han's inequality, we show that the lack of opportunity to apply these two coding strategies directly implies the optimality of superposition coding. It is further shown that under a set of particular security constraints, one of the proposed joint coding strategies can be used to construct a code that achieves the optimal rate region.Comment: The paper has been accepted by IEEE Transactions on Information Theor

Reduced coupling between offline neural replay events and default mode network activation in schizophrenia

Schizophrenia is characterized by an abnormal resting state and default mode network brain activity. However, despite intense study, the mechanisms linking default mode network dynamics to neural computation remain elusive. During rest, sequential hippocampal reactivations, known as 'replay', are played out within default mode network activation windows, highlighting a potential role of replay-default mode network coupling in memory consolidation and model-based mental simulation. Here, we test a hypothesis of reduced replay-default mode network coupling in schizophrenia, using magnetoencephalography and a non-spatial sequence learning task designed to elicit off-task (i.e. resting state) neural replay. Participants with a diagnosis of schizophrenia (n = 28, mean age 28.2 years, range 20-40, 6 females, 13 not taking antipsychotic medication) and non-clinical control participants (n = 29, mean age 28.1 years, range 18-45, 6 females, matched at group level for age, intelligence quotient, gender, years in education and working memory) underwent a magnetoencephalography scan both during task completion and during a post-task resting state session. We used neural decoding to infer the time course of default mode network activation (time-delay embedding hidden Markov model) and spontaneous neural replay (temporally delayed linear modelling) in resting state magnetoencephalography data. Using multiple regression, we then quantified the extent to which default mode network activation was uniquely predicted by replay events that recapitulated the learned task sequences (i.e. 'task-relevant' replay-default mode network coupling). In control participants, replay-default mode network coupling was augmented following sequence learning, an augmentation that was specific for replay of task-relevant (i.e. learned) state transitions. This task-relevant replay-default mode network coupling effect was significantly reduced in schizophrenia (t(52) = 3.93, P = 0.018). Task-relevant replay-default mode network coupling predicted memory maintenance of learned sequences (ρ(52) = 0.31, P = 0.02). Importantly, reduced task-relevant replay-default mode network coupling in schizophrenia was not explained by differential replay or altered default mode network dynamics between groups nor by reference to antipsychotic exposure. Finally, task-relevant replay-default mode network coupling during rest correlated with stimulus-evoked default mode network modulation as measured in a separate task session. In the context of a proposed functional role of replay-default mode network coupling, our findings shed light on the functional significance of default mode network abnormalities in schizophrenia and provide for a consilience between task-based and resting state default mode network findings in this disorder

Decoding cognition from spontaneous neural activity

In human neuroscience, studies of cognition are rarely grounded in non-task-evoked, ‘spontaneous’ neural activity. Indeed, studies of spontaneous activity tend to focus predominantly on intrinsic neural patterns (for example, resting-state networks). Taking a ‘representation-rich’ approach bridges the gap between cognition and resting-state communities: this approach relies on decoding task-related representations from spontaneous neural activity, allowing quantification of the representational content and rich dynamics of such activity. For example, if we know the neural representation of an episodic memory, we can decode its subsequent replay during rest. We argue that such an approach advances cognitive research beyond a focus on immediate task demand and provides insight into the functional relevance of the intrinsic neural pattern (for example, the default mode network). This in turn enables a greater integration between human and animal neuroscience, facilitating experimental testing of theoretical accounts of intrinsic activity, and opening new avenues of research in psychiatry

Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.

Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI. Methods:We studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. Models were adjusted for demographic characteristics, diabetes status and albuminuria. Results:During median follow-up of 8.5 years, mean rate of eGFR loss was -0.31 mL/min/1.73 m2/year overall, and 73 individuals experienced AKI (55% Stage 1). A significant interaction existed between AKI and source of serum creatinine for acute absolute change in eGFR level after discharge; in contrast, AKI was independently associated with a faster rate of eGFR decline (mean additional loss of -0.67 mL/min/1.73 m2/year), which was not impacted by source of serum creatinine. Conclusions:AKI is independently associated with subsequent steeper eGFR decline regardless of the serum creatinine source used, but the strength of association is smaller than observed in prior studies after taking into account key confounders such as pre-AKI eGFR slope and albuminuria