Small area estimation for spatially correlated populations - a comparison of direct and indirect model-based methods

Linear mixed models underpin many small area estimation (SAE) methods. In this paper we investigate SAE based on linear models with spatially correlated small area effects where the neighbourhood structure is described by a contiguity matrix. Such models allow efficient use of spatial auxiliary information in SAE. In particular, we use simulation studies to compare the performances of model-based direct estimation (MBDE) and empirical best linear unbiased prediction (EBLUP) under such models. These simulations are based on theoretically generated populations as well as data obtained from two real populations (the ISTAT farm structure survey in Tuscany and the US Environmental Monitoring and Assessment Program survey). Our empirical results show only marginal gains when spatial dependence between areas is incorporated into the SAE model

Disease Mapping via Negative Binomial Regression M-quantiles

We introduce a semi-parametric approach to ecological regression for disease mapping, based on modelling the regression M-quantiles of a Negative Binomial variable. The proposed method is robust to outliers in the model covariates, including those due to measurement error, and can account for both spatial heterogeneity and spatial clustering. A simulation experiment based on the well-known Scottish lip cancer data set is used to compare the M-quantile modelling approach and a random effects modelling approach for disease mapping. This suggests that the M-quantile approach leads to predicted relative risks with smaller root mean square error than standard disease mapping methods. The paper concludes with an illustrative application of the M-quantile approach, mapping low birth weight incidence data for English Local Authority Districts for the years 2005-2010.Comment: 23 pages, 7 figure

Shyness, sensation seeking and birth-order position

The study found no relationship between birth-order position and shyness or sensation seeking in a sample of 250 students. Shyness was significantly negatively correlated with total sensation seeking scores and scores on the four subscales, but closer analysis showed that this relationship was mediated by the correlation between shyness and disinhibition. This pattern implies that shyness is wariness specifically in social situations

Small volume laboratory on a chip measurements incorporating the quartz crystal microbalance to measure the viscosity-density product of room temperature ionic liquids

A microfluidic glass chip system incorporating a quartz crystal microbalance (QCM) to measure the square root of the viscosity-density product of room temperature ionic liquids (RTILs) is presented. The QCM covers a central recess on a glass chip, with a seal formed by tightly clamping from above outside the sensing region. The change in resonant frequency of the QCM allows for the determination of the square root viscosity-density product of RTILs to a limit of ∼ 10 kg m−2 s−0.5. This method has reduced the sample size needed for characterization from 1.5 ml to only 30 μl and allows the measurement to be made in an enclosed system

Imaging Impulsivity in Parkinson's Disease and the Contribution of the Subthalamic Nucleus

Taking risks is a natural human response, but, in some, risk taking is compulsive and may be detrimental. The subthalamic nucleus (STN) is thought to play a large role in our ability to inhibit responses. Differences between individuals' ability to inhibit inappropriate responses may underlie both the normal variation in trait impulsivity in the healthy population, as well as the pathological compulsions experienced by those with impulse control disorders (ICDs). Thus, we review the role of the STN in response inhibition, with a particular focus on studies employing imaging methodology. We also review the latest evidence that disruption of the function of the STN by deep brain stimulation in patients with Parkinson's disease can increase impulsivity

Outlier robust small area estimation

Recently proposed outlier robust small area estimators can be substantially biased when outliers are drawn from a distribution that has a different mean from that of the rest of the survey data. This naturally leads one to consider an outlier robust bias correction for these estimators. We develop this idea, proposing two different analytical mean-squared error estimators for the ensuing bias-corrected outlier robust estimators. Simulations based on realistic outlier-contaminated data show that the bias correction proposed often leads to more efficient estimators. Furthermore, the mean-squared error estimation methods proposed appear to perform well with a variety of outlier robust small area estimators

Correlation regimes in fluctuations of fatigue crack growth

This paper investigates correlation properties of fluctuations in fatigue crack growth of polycrystalline materials, such as ductile alloys, that are commonly encountered in structures and machinery components of complex electromechanical systems. The model of crack damage measure indicates that the fluctuations of fatigue crack growth are characterized by strong correlation patterns within short time scales and are uncorrelated for larger time scales. The two correlation regimes suggest that the 7075-T6 aluminum alloy, analyzed in this paper, is characterized by a micro-structure which is responsible for an intermittent correlated dynamics of fatigue crack growth within a certain scale. The constitutive equations of the damage measure are built upon the physics of fracture mechanics and are substantiated by Karhunen-Lo\`{e}ve decomposition of fatigue test data. Statistical orthogonality of the estimated damage measure and the resulting estimation error is demonstrated in a Hilbert space setting.Comment: 30 pages, 8 figures, to appear in Physica

Neuroinflammation in mild cognitive impairment and Alzheimer's disease: A meta-analysis.

BACKGROUND:Increasingly, evidence from brain imaging supports the role of neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial and temporal susceptibility to neuroinflammatory processes in the brain that may correspond to dementia staging or symptom expression. METHODS:We searched literature databases for case-control studies examining levels of translocator protein (TSPO) levels using positron emission tomography, representing neuroinflammation, in regional analyses between healthy controls and mild cognitive impairment (MCI) or Alzheimer's disease (AD) subjects. Standardised mean differences (SMDs) were calculated and results meta-analysed using random-effects models. Quality assessments, sensitivity analysis, subgroup analysis and meta-regressions were also performed. RESULTS:Twenty-eight studies comprising 755 (HC = 318, MCI = 168, AD = 269) participants and 37 brain regions were included. Compared to HCs, AD participants had increased TSPO levels throughout the brain (SMD range: 0.43 - 1.76), especially within fronto-temporal regions. MCI subjects also had increased TSPO levels, mainly within the neocortex, with more modest effects (SMD range: 0.46 - 0.90). Meta-regression analysis identified an inverse association between TSPO levels in the parietal region and Mini-Mental State Examination scores, a proxy for disease severity, in AD subjects (estimate: -0.11, 95% confidence interval: -0.21 to -0.02; P = 0.024). CONCLUSIONS:Our findings support the association of increased neuroinflammation during the progression of MCI and AD, relative to HCs

Using coloured filters to reduce the symptoms of visual stress in children with reading delay

Background: Meares Irlen Syndrome (MIS), otherwise known as “visual stress”, is one condition that can cause difficulties with reading. Aim: This study aimed to compare the effect of two coloured-filter systems on the symptoms of visual stress in children with reading delay. Methods: The study design was a pre-test, post-test, randomized head-to-head comparison of two filter systems on the symptoms of visual stress in school children. A total of 68 UK mainstream schoolchildren with significant impairment in reading ability completed the study. Results: The filter systems appeared to have a large effect on the reported symptoms between pre and post three-month time points (d = 2.5, r = 0.78). Both filter types appeared to have large effects (Harris d = 1.79, r = 0.69 and DRT d = 3.22, r = 0.85). Importantly, 35% of participants’ reported that their symptoms had resolved completely; 72% of the 68 children appeared to gain improvements in three or more visual stress symptoms. Conclusion and significance: The reduction in symptoms, which appeared to be brought about by the use of coloured filters, eased the visual discomfort experienced by these children when reading. This type of intervention therefore has the potential to facilitate occupational engagement