Evidence of two spectral breaks in the prompt emission of gamma ray bursts

The long-lasting tension between the observed spectra of gamma ray bursts (GRBs) and the predicted synchrotron emission spectrum might be solved if electrons do not completely cool. Evidence for incomplete cooling was recently found in Swift GRBs with prompt observations down to 0.1 keV and in one bright Fermi burst, GRB 160625B. Here we systematically search for evidence of incomplete cooling in the spectra of the ten brightest short and long GRBs observed by Fermi. We find that in 8/10 long GRBs there is compelling evidence of a low energy break (below the peak energy) and good agreement with the photon indices of the synchrotron spectrum (respectively -2/3 and -3/2 below the break and between the break and the peak energy). Interestingly, none of the ten short GRBs analysed shows a break but the low energy spectral slope is consistent with -2/3. In a standard scenario, these results imply a very low magnetic field in the emission region (B' ~ 10 G in the comoving frame), at odd with expectations.Comment: 14 pages, 15 figures, in press, accepted for publication in A&

The short gamma-ray burst population in a quasi-universal jet scenario

We describe a model of the short gamma-ray burst (SGRB) population under a `quasi-universal jet' scenario in which jets can differ in their on-axis peak prompt emission luminosity $L_c$, but share a universal angular luminosity profile $\ell(\theta_v)=L(\theta_v)/L_c$ as a function of the viewing angle $\theta_v$. The model is fitted, through a Bayesian hierarchical approach inspired by gravitational wave (GW) population analyses, to 3 observed SGRB samples simultaneously: the Fermi/GBM sample of SGRBs with spectral information in the catalogue (367 events); a flux-complete sample of 16 Swift/BAT SGRBs also detected by GBM, with a measured redshift; and a sample of SGRBs with a binary neutron star (BNS) merger counterpart, which only includes GRB~170817A at present. The results favour a narrow jet core with half-opening angle $\theta_c=2.1_{-1.4}^{+2.4}$ deg (90\% credible intervals from our fiducial `full sample' analysis) whose on-axis peak luminosity is distributed as $p(L_c) \propto L_c^{-A}$ with $A=3.2_{-0.4}^{+0.7}$ above a minimum luminosity $L_c^\star = 5_{-2}^{+11}\times 10^{51}$ erg s$^{-1}$. For $\theta_v>\theta_c$, the luminosity scales as a power law $\ell\propto \theta_v^{-\alpha_L}$ with $\alpha_L=4.7_{-1.4}^{+1.2}$, with no evidence for a break. While the model implies an intrinsic `Yonetoku' correlation between $L$ and the peak photon energy $E_p$, its slope is somewhat shallower $E_p\propto L^{0.4\pm 0.2}$ than the apparent one, and the normalization is offset towards larger $E_p$, due to selection effects. The implied local rate density of SGRBs is between about 100 up to several thousands of events per Gpc$^{3}$ yr, in line with the BNS merger rate density inferred from GW observations. Based on the model, we predict 0.2 to 1.3 joint GW+SGRB detections per year by the Advanced GW detector network and Fermi/GBM during the O4 observing run.Comment: 30 pages, 23 figures, submitted to A&A. Comments are welcome

Consistency with synchrotron emission in the bright GRB 160625B observed by Fermi

We present time-resolved spectral analysis of prompt emission from GRB 160625B, one of the brightest bursts ever detected by Fermi in its nine years of operations. Standard empirical functions fail to provide an acceptable fit to the GBM spectral data, which instead require the addition of a low-energy break to the fitting function. We introduce a new fitting function, called 2SBPL, consisting of three smoothly connected power laws. Fitting this model to the data, the goodness of the fits significantly improves and the spectral parameters are well constrained. We also test a spectral model that combines non-Thermal and thermal (black body) components, but find that the 2SBPL model is systematically favoured. The spectral evolution shows that the spectral break is located around Ebreak ~100 keV, while the usual νFν peak energy feature Epeak evolves in the 0.5-6 MeV energy range. The slopes below and above Ebreak are consistent with the values-0.67 and-1.5, respectively, expected from synchrotron emission produced by a relativistic electron population with a low-energy cut-off. If Ebreak is interpreted as the synchrotron cooling frequency, the implied magnetic field in the emitting region is ~10 Gauss, i.e. orders of magnitudes smaller than the value expected for a dissipation region located at ~1013-14 cm from the central engine. The low ratio between Epeak and Ebreak implies that the radiative cooling is incomplete, contrary to what is expected in strongly magnetized and compact emitting regions

Wide band X-ray and optical observations of the BL Lac object 1ES 1959+650 in high state

The blazar 1ES 1959+650 was observed twice by BeppoSAX in September 2001 simultaneously with optical observations. We report here the X-ray data together with the optical, R_C magnitude, light curve since August 1995. The BeppoSAX observations were triggered by an active X-ray status of the source. The X-ray spectra are brighter than the previously published X-ray observations, although the source was in an even higher state a few months later, as monitored by the ASM onboard RossiXTE, when it was also detected to flare in the TeV band. Our X-ray spectra are well represented by a continuosly curved model up to 45 keV and are interpreted as synchrotron emission, with the peak moving to higher energies. This is also confirmed by the slope of the X-ray spectrum which is harder than in previous observations. Based on our optical and X-ray data, the synchrotron peak turns out to be in the range 0.1-0.7 keV. We compare our data with non simultaneous radio to TeV data and model the spectral energy distribution with a homogeneous, one-zone synchrotron inverse Compton model. We derive physical parameters that are typical of low power High Energy peaked Blazar, characterised by a relatively large beaming factor, low luminosity and absence of external seed photons.Comment: 12 pages, 6 figures, accepted by A&

Conditional Agreements For Innovative Therapies In Italy: The Case Of Pirfenidone

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XMM-Newton observation of the 5.25 ms transient millisecond pulsar XTE J1807-294 in outburst

We report on the results obtained for the millisecond transient X-ray pulsar XTE J1807-294 in a 40 min orbital period system, based on an XMM-Newton ToO observation carried out during March 2003. The source was found at a luminosity level of about 2x10^36 erg/s in the 0.5-10 keV range (assuming a distance of 8 kpc). We confirm the presence of the 5.25 ms pulsations (after accounting for the orbital modulation) and find a pulsed fraction of 5.8% in the 0.3-10 keV band. The pulse shape in nearly sinusoidal. The spectral continuum of the source is well fitted by an absorbed Comptonization model plus a soft component. No emission or absorption lines have been detected in the 0.5-10 keV range with upper limits of 10-40 eV. The reported analysis represent the first detailed study of this source, the fourth belonging to the ultra-compact binary system class hosting an accreting neutron star.Comment: Accepted for publication in ApJ

In silico identification of new putative pathogenic variants in the NEU1 sialidase gene affecting enzyme function and subcellular localization

The NEU1 gene is the first identified member of the human sialidases, glycohydrolitic enzymes that remove the terminal sialic acid from oligosaccharide chains. Mutations in NEU1 gene are causative of sialidosis (MIM 256550), a severe lysosomal storage disorder showing autosomal recessive mode of inheritance. Sialidosis has been classified into two subtypes: sialidosis type I, a normomorphic, late-onset form, and sialidosis type II, a more severe neonatal or early-onset form. A total of 50 causative mutations are reported in HGMD database, most of which are missense variants. To further characterize the NEU1 gene and identify new functionally relevant protein isoforms, we decided to study its genetic variability in the human population using the data generated by two large sequencing projects: the 1000 Genomes Project (1000G) and the NHLBI GO Exome Sequencing Project (ESP). Together these two datasets comprise a cohort of 7595 sequenced individuals, making it possible to identify rare variants and dissect population specific ones. By integrating this approach with biochemical and cellular studies, we were able to identify new rare missense and frameshift alleles in NEU1 gene. Among the 9 candidate variants tested, only two resulted in significantly lower levels of sialidase activity (pC and c.700G>A. These two mutations give rise to the amino acid substitutions p.V217A and p.D234N, respectively. NEU1 variants including either of these two amino acid changes have 44% and 25% residual sialidase activity when compared to the wild-type enzyme, reduced protein levels and altered subcellular localization. Thus they may represent new, putative pathological mutations resulting in sialidosis type I. The in silico approach used in this study has enabled the identification of previously unknown NEU1 functional alleles that are widespread in the population and could be tested in future functional studies

Continuous rate infusion of dexmedetomidine vs subcutaneous administration in anaesthetized horses undergoing MRI examination

Up to 2005, dexmedetomidine use had not been reported in equine. Since then, several experimental and clinical studies have been published. The main reason for this increase relies on its beneficial pharmacological profile, including short half-life and rapid redistribution (1). The aim of the study is to compare the clinical effects and recovery quality after continuous rate infusion (CRI) or subcutaneous administration of dexmedetomidine in horses undergoing general anaesthesia. Fourteen horses scheduled for MRI examination were included. All horses were sedated with acepromazine 0.03 mg kg-1 intravenously (IV) and detomidine 10 \ub5g kg-1 (IV). Anaesthesia was induced with ketamine 3 mg kg-1 (IV) and diazepam 0.04 mg kg-1 (IV) and maintained with isofluorane in 60% oxygen; end-tidal isoflurane concentration was maintained between 1.3-1.4 %. Horses were randomly divided in two groups. Group \u201cDex CRI\u201d received dexmedetomidine intravenously at 1 \ub5g kg-1 hour-1, group \u201cDex SC\u201d received 2 \ub5g kg-1 of dexmedetomidine subcutaneously every 60 minutes. If nystagmus or incessant fighting against ventilator occurred, ketamine rescue at 0.1 mg kg-1 was given. In case of sudden movements, thiopental 0.5-1.0 mg kg-1 IV was given. Ringer\u2019s lactate was given at 3 mL kg-1 hour-1, dobutamine was administered IV and the rate adjusted to maintain MAP>70 mmHg. Controlled mechanical ventilation using intermittent positive pressure ventilation was adjusted to maintain arterial carbon dioxide partial pressure between 38-45 mmHg. Heart rate, invasive arterial blood pressure, arterial blood gases, total dose of dobutamine administered, ketamine rescue needed, urine production were recorded. Time required until extubation and time to attain sternal and standing position were noted. The main anaesthesiologist assessed recovery quality graded on a standard scoring 5-point scale with a score of 1 representing the best recovery (2). Mann-Whitney U test was applied for non-parametric data and T-test for parametric data (p 640.05). There was no statistically differences in physiological intra-anaesthetic parameters, in body weight (kg) (CRI 521\ub153; SC 506\ub176), age (years) (CRI 10.7\ub12.1; SC 10.8\ub14.1), anaesthesia duration (min) (CRI 139\ub19.,7; SC 144\ub116.2), number of ketamine rescue needed (CRI 1\ub11.15; SC 0.5\ub11.13), recovery score (CRI 1.8\ub11,2; SC 1.5\ub10,5). Also time until extubation (min) (CRI 11.5\ub15.0; SC 9.7\ub12.6), time to attain sternal (min) (CRI 41.5\ub112.2; SC 49.7\ub16.0) and standing position (min) (CRI 50.7\ub114.6; SC 57.2\ub16.,0) were not statistically different. There was statistical significance in urine production (L) (CRI 8.0\ub13.5; SC 11.1\ub14.4) and total dobutamine mcg/kg/min (CRI 0.89\ub10.35; SC 0.56\ub10.18). Subcutaneous administration of dexmedetomidine has product similar clinical effects to those achieved with CRI. It has permitted a significative reduction in dobutamine administration and a more stable depth of anaesthesia confirmed by the lower number of rescue ketamine boluses required even if not statistically different. Further studies are required to evaluate different dosages both in CRI and subcutaneous administration