Interlayer hybridization of virgin carbon, recycled carbon and natural fiber laminates

To meet sustainability objectives in the transport sector, natural fiber (NF) and recycled carbon fiber (RCF) have been developed, although they have been typically limited to low to medium performance components. This work has considered the effect of interlayer hybridization of woven NF and non-woven RCF with woven virgin carbon fibers (VCF) on the mechanical and damping performance of hybrid laminates, produced using double bag vacuum infusion (DBVI). The mean damping ratio of the pure laminates showed a trend of NF>RCF>VCF, which was inversely proportional to their modulus. The tensile, flexural and damping properties of hybrid laminates were dominated by the outermost ply. The VCF-RCF and VCF-NF hybrid laminates showed a comparatively greater mean damping ratio. The results of this work demonstrate a method for the uptake of alternative materials with a minimal impact on the mechanical properties and improved damping performance. View Full-Tex

Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model

HER2-targeted therapy has improved breast cancer survival, but treatment resistance and disease prevention remain major challenges. Genes that enable HER2/Neu oncogenesis are the next intervention targets. A bioinformatics discovery platform of HER2/Neu-expressing Diversity Outbred (DO) F1 Mice was established to identify cancer-enabling genes. Quantitative Trait Loci (QTL) associated with onset ages and growth rates of spontaneous mammary tumors were sought. Twenty-six genes in 3 QTL contain sequence variations unique to the genetic backgrounds that are linked to aggressive tumors and 21 genes are associated with human breast cancer survival. Concurrent identification of TSC22D3, a transcription factor, and its target gene LILRB4, a myeloid cell checkpoint receptor, suggests an immune axis for regulation, or intervention, of disease. We also investigated TIEG1 gene that impedes tumor immunity but suppresses tumor growth. Although not an actionable target, TIEG1 study revealed genetic regulation of tumor progression, forming the basis of the genetics-based discovery platform

Government Spending and Inclusive-Growth Relationship in Nigeria: An Empirical Investigation

This study has investigated the relationship between government spending and inclusive growth in Nigeria over the period 1995 to 2014. Specifically, it examined how, and to what extent, government spending on education, government spending on health, economic freedom, public resource use, and real GDP growth rate have impacted on inclusive growth in the country. It used the Dickey-Fuller GLS unit root test to ascertain the order of integration of the series. Consequently, through the Auto-Regressive Distributed Lag (ARDL) bound testing technique, the study found that in the long-run government spending on health, economic freedom, public resource use and real GDP growth rate had significantly positive influence on inclusive growth. In the short-run, however, only real GDP impacted significantly on inclusive growth while other variables were not significant in causing inclusive growth. Thus, in conclusion, government spending in the form of redistributive spending on health propelled inclusive growth in Nigeria