Influence of nanosecond microwave pulses on the level of cortycosterone

This article describes experimental data on 30 nonlinear rats exposed to microwave radiation at frequencies 8, 13, 16 and 22 pulse per second (pps) in order to record corticosteron changes as an indicator of stress in rodent blood. During the experiment, it was found that the most significant increase is observed at frequencies 13, 16 pps and at 22, 8 pps a decrease and a slight increase in corticosteron were recorded respectively

Parametrization of dark energy equation of state Revisited

A comparative study of various parametrizations of the dark energy equation of state is made. Astrophysical constraints from LSS, CMB and BBN are laid down to test the physical viability and cosmological compatibility of these parametrizations. A critical evaluation of the 4-index parametrizations reveals that Hannestad-M\"{o}rtsell as well as Lee parametrizations are simple and transparent in probing the evolution of the dark energy during the expansion history of the universe and they satisfy the LSS, CMB and BBN constraints on the dark energy density parameter for the best fit values.Comment: 11 page

Production and properties of thin film materials sol-gel by method based on TiO[2]-MxOy, where M-Ni, Cu, Zn

The physical-chemical, morphological, and structural properties of thin-film TiO[2]-MxOy obtained by sol-gel method were investigated. Titanium sol is formed by controlled hydrolysis of tetrabutoxy titanium in acidic media. The effect of synthesis and calcination temperature on the phase, crystal size was studied using Xray phase analysis (XRD), scanning electron microscopy (SEM). XRD observations confirmed the nanocrystalline nature of TiO[2]

Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

Development and homeostasis of multicellular organisms is largely controlled by complex cell-cell signaling networks that rely on specific binding of secreted ligands to cell surface receptors. The Wnt signaling network, as an example, involves multiple ligands and receptors to elicit specific cellular responses. To understand the mechanisms of such a network, ligand-receptor interactions should be characterized quantitatively, ideally in live cells or tissues. Such measurements are possible using fluorescence microscopy yet challenging due to sample movement, low signal-to-background ratio and photobleaching. Here, we present a robust approach based on fluorescence correlation spectroscopy with ultra-high speed axial line scanning, yielding precise equilibrium dissociation coefficients of interactions in the Wnt signaling pathway. Using CRISPR/Cas9 editing to endogenously tag receptors with fluorescent proteins, we demonstrate that the method delivers precise results even with low, near-native amounts of receptors

The Extrachromosomal EAST Protein of Drosophila Can Associate with Polytene Chromosomes and Regulate Gene Expression

The EAST protein of Drosophila is a component of an expandable extrachromosomal domain of the nucleus. To better understand its function, we studied the dynamics and localization of GFP-tagged EAST. In live larval salivary glands, EAST-GFP is highly mobile and localizes to the extrachromosomal nucleoplasm. When these cells are permeabilized, EAST-GFP rapidly associated with polytene chromosomes. The affinity to chromatin increases and mobility decreases with decreasing salt concentration. Deleting the C-terminal residues 1535 to 2301 of EAST strongly reduces the affinity to polytene chromosomes. The bulk of EAST-GFP co-localizes with heterochromatin and is absent from transcriptionally active chromosomal regions. The predominantly chromosomal localization of EAST-GFP can be detected in non-detergent treated salivary glands of pupae as they undergo apoptosis, however not in earlier stages of development. Consistent with this chromosomal pattern of localization, genetic evidence indicates a role for EAST in the repression of gene expression, since a lethal east mutation is allelic to the viable mutation suppressor of white-spotted. We propose that EAST acts as an ion sensor that modulates gene expression in response to changing intracellular ion concentrations

Анализ применимости численных алгоритмов для моделирования процессов в топке котла с циркулирующим кипящим слоем

Моделирование различных задач связано с решением систем дифференциальных уравнений с большим числом неизвестных, что приводит к их упрощению и соответственно отражается на качестве расчета. Данная работа направлена на оценку применимости тех или иных математических алгоритмов для получения качественного моделирования процессов в энергетических котлах с циркулирующим кипящим слоемModeling of various tasks related to the solution of systems of differential equations with a large number of unknowns, which leads to their simplification and, accordingly, affect the quality of the calculation. This work aims to assess the applicability of those or other mathematical algorithms to obtain a quantitative simulation of processes in power boilers with circulating fluidized bed

Перспективы развития фундаментальных наук: сборник научных трудов XI Международной конференция студентов и молодых ученых, г. Томск, 22-25 апреля 2014 г.

Сборник содержит труды участников XI Международной конференции студентов и молодых учёных "Перспективы развития фундаментальных наук". Включает доклады студентов и молодых ученых, представленные на секциях "физика", "химия", "математика", "технология", наноматериалы и нанотехнологии», "IT-технологии и электроника". В рамках секций представлены доклады студентов представленные для соискания стипендий по программе У.М.Н.И.К. Сборник представляет интерес для студентов, аспирантов, молодых ученых, преподавателей в области естественных наук и высшей математик

The Flexible Ocean and Climate Infrastructure Version 1 (FOCI1): Mean State and Variability

A new Earth system model, the Flexible Ocean and Climate Infrastructure (FOCI), is introduced. A first version of FOCI consists of a global high-top atmosphere (ECHAM6.3) and an ocean model (NEMO3.6) as well as sea ice (LIM2) and land surface model components (JSBACH), which are coupled through the OASIS3-MCT software package. FOCI includes a number of optional modules which can be activated depending on the scientific question of interest. In the atmosphere, interactive stratospheric chemistry can be used (ECHAM6-HAMMOZ) to study, for example, the effects of the ozone hole on the climate system. In the ocean, a biogeochemistry model (MOPS) is available to study the global carbon cycle. A unique feature of FOCI is the ability to explicitly resolve mesoscale ocean eddies in specific regions. This is realized in the ocean through nesting; first examples for the Agulhas Current and the Gulf Stream systems are described here. FOCI therefore bridges the gap between coarse-resolution climate models and global high-resolution weather prediction and ocean-only models. It allows to study the evolution of the climate system on regional and seasonal to (multi-) decadal scales. The development of FOCI resulted from a combination of the long-standing expertise in ocean and climate modeling in several research units and divisions at GEOMAR. FOCI will thus be used to complement and interpret long-term observations in the Atlantic, enhance the process understanding of the role of mesoscale oceanic eddies for large-scale oceanic and atmospheric circulation patterns, study feedback mechanisms with stratospheric processes, estimate future ocean acidification, improve the simulation of the Atlantic Meridional Overturning Circulation changes and their influence on climate, ocean chemistry and biology. In this paper we present both the scientific vision for the development of FOCI as well as some technical details. This includes a first validation of the different model components using several configurations of FOCI. Results show that the model in its basic configuration runs stably under pre-industrial control as well as under historical forcing, and produces a mean climate and variability which compares well with observations, reanalysis products and other climate models. The nested configurations reduce some long-standing biases in climate models and are an important step forward to include the atmospheric response in multi-decadal eddy-rich configurations

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR

Double-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site. The sample was illuminated in the NMR rotor at low temperature (similar to 120 K) in order to trap the primary photointermediate, bathorhodopsin. The NMR data are consistent with a strong torsional twist of the HCCH moiety at the isomerization site. Although the HCCH torsional twist was determined to be at least 40A degrees, it was not possible to quantify it more closely. The presence of a strong twist is in agreement with previous Raman observations. The energetic implications of this geometric distortion are discussed

Simulation techniques in energy analysis

Simulation is one of the most frequently used techniques in energy modelling. After some general remarks on the nature of simulation models, a more detailed description of a large scale dynamic energy simulation model for the Federal Republic of Germany is given. The paper continues with a discussion of some model results and concludes with some brief remarks on the limitations of the simulation approach