258 research outputs found
Demonstration and Comparison of Operation of Photomultiplier Tubes at Liquid Argon Temperature
Liquified noble gases are widely used as a target in direct Dark Matter
searches. Signals from scintillation in the liquid, following energy deposition
from the recoil nuclei scattered by Dark Matter particles (e.g. WIMPs), should
be recorded down to very low energies by photosensors suitably designed to
operate at cryogenic temperatures. Liquid Argon based detectors for Dark Matter
searches currently implement photo multiplier tubes for signal read-out. In the
last few years PMTs with photocathodes operating down to liquid Argon
temperatures (87 K) have been specially developed with increasing Quantum
Efficiency characteristics. The most recent of these, Hamamatsu Photonics Mod.
R11065 with peak QE up to about 35%, has been extensively tested within the R&D
program of the WArP Collaboration. During these testes the Hamamatsu PMTs
showed superb performance and allowed obtaining a light yield around 7
phel/keVee in a Liquid Argon detector with a photocathodic coverage in the 12%
range, sufficient for detection of events down to few keVee of energy
deposition. This shows that this new type of PMT is suited for experimental
applications, in particular for new direct Dark Matter searches with LAr-based
experiments
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis
Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need. Oxysterols are oxidised cholesterol derivatives with important roles in various biological processes. The enzyme cholesterol 25-hydroxylase [CH25H] converts cholesterol to 25-hydroxycholesterol [25-HC], which modulates immune responses and oxidative stress. In human intestinal samples from CD patients, we found a strong correlation of CH25H mRNA expression with the expression of fibrosis markers. We demonstrate reduced intestinal fibrosis in mice deficient for the CH25H enzyme, using the sodium dextran sulphate [DSS]-induced chronic colitis model. Additionally, using a heterotopic transplantation model of intestinal fibrosis, we demonstrate reduced collagen deposition and lower concentrations of hydroxyproline in CH25H knockouts. In the heterotopic transplant model, CH25H was expressed in fibroblasts. Taken together, our findings indicate an involvement of oxysterol synthesis in the pathogenesis of intestinal fibrosis
Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors
We report on the first measurement of 39Ar in argon from underground natural
gas reservoirs. The gas stored in the US National Helium Reserve was found to
contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be
<=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon
(39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National
Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most
important backgrounds in argon detectors for WIMP dark matter searches. The
findings reported demonstrate the possibility of constructing large multi-ton
argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table
Performance Of A Liquid Argon Time Projection Chamber Exposed To The WANF Neutrino Beam
We present the results of the first exposure of a Liquid Argon TPC to a
multi-GeV neutrino beam. The data have been collected with a 50 liters
ICARUS-like chamber located between the CHORUS and NOMAD experiments at the
CERN West Area Neutrino Facility (WANF). We discuss both the instrumental
performance of the detector and its capability to identify and reconstruct low
multiplicity neutrino interactions.Comment: 14 pages, 12 figures. Submitted for publication to Physical Review
Underground operation of the ICARUS T600 LAr-TPC: first results
Open questions are still present in fundamental Physics and Cosmology, like
the nature of Dark Matter, the matter-antimatter asymmetry and the validity of
the particle interaction Standard Model. Addressing these questions requires a
new generation of massive particle detectors exploring the subatomic and
astrophysical worlds. ICARUS T600 is the first large mass (760 ton) example of
a novel detector generation able to combine the imaging capabilities of the old
famous "bubble chamber" with an excellent energy measurement in huge electronic
detectors. ICARUS T600 now operates at the Gran Sasso underground laboratory,
studying cosmic rays, neutrino oscillation and proton decay. Physical
potentialities of this novel telescope are presented through few examples of
neutrino interactions reconstructed with unprecedented details. Detector design
and early operation are also reported.Comment: 14 pages, 8 figures, 2 tables. Submitted to Jins
Precision measurement of the neutrino velocity with the ICARUS detector in the CNGS beam
During May 2012, the CERN-CNGS neutrino beam has been operated for two weeks
for a total of 1.8 10^17 pot in bunched mode, with a 3 ns narrow width proton
beam bunches, separated by 100 ns. This tightly bunched beam structure allows a
very accurate time of flight measurement of neutrinos from CERN to LNGS on an
event-by-event basis. Both the ICARUS-T600 PMT-DAQ and the CERN-LNGS timing
synchronization have been substantially improved for this campaign, taking
ad-vantage of additional independent GPS receivers, both at CERN and LNGS as
well as of the deployment of the "White Rabbit" protocol both at CERN and LNGS.
The ICARUS-T600 detector has collected 25 beam-associated events; the
corresponding time of flight has been accurately evaluated, using all different
time synchronization paths. The measured neutrino time of flight is compatible
with the arrival of all events with speed equivalent to the one of light: the
difference between the expected value based on the speed of light and the
measured value is tof_c - tof_nu = (0.10 \pm 0.67stat. \pm 2.39syst.) ns. This
result is in agreement with the value previously reported by the ICARUS
collaboration, tof_c - tof_nu = (0.3 \pm 4.9stat. \pm 9.0syst.) ns, but with
improved statistical and systematic errors.Comment: 21 pages, 13 figures, 1 tabl
A Proposal for a Three Detector Short-Baseline Neutrino Oscillation Program in the Fermilab Booster Neutrino Beam
A Short-Baseline Neutrino (SBN) physics program of three LAr-TPC detectors
located along the Booster Neutrino Beam (BNB) at Fermilab is presented. This
new SBN Program will deliver a rich and compelling physics opportunity,
including the ability to resolve a class of experimental anomalies in neutrino
physics and to perform the most sensitive search to date for sterile neutrinos
at the eV mass-scale through both appearance and disappearance oscillation
channels. Using data sets of 6.6e20 protons on target (P.O.T.) in the LAr1-ND
and ICARUS T600 detectors plus 13.2e20 P.O.T. in the MicroBooNE detector, we
estimate that a search for muon neutrino to electron neutrino appearance can be
performed with ~5 sigma sensitivity for the LSND allowed (99% C.L.) parameter
region. In this proposal for the SBN Program, we describe the physics analysis,
the conceptual design of the LAr1-ND detector, the design and refurbishment of
the T600 detector, the necessary infrastructure required to execute the
program, and a possible reconfiguration of the BNB target and horn system to
improve its performance for oscillation searches.Comment: 209 pages, 129 figure
Measurement of Through-Going Particle Momentum By Means Of Multiple Scattering With The ICARUS T600 TPC
The ICARUS collaboration has demonstrated, following the operation of a 600
ton (T600) detector at shallow depth, that the technique based on liquid Argon
TPCs is now mature. The study of rare events, not contemplated in the Standard
Model, can greatly benefit from the use of this kind of detectors. In
particular, a deeper understanding of atmospheric neutrino properties will be
obtained thanks to the unprecedented quality of the data ICARUS provides.
However if we concentrate on the T600 performance, most of the
charged current sample will be partially contained, due to the reduced
dimensions of the detector. In this article, we address the problem of how well
we can determine the kinematics of events having partially contained tracks.
The analysis of a large sample of atmospheric muons collected during the T600
test run demonstrate that, in case the recorded track is at least one meter
long, the muon momentum can be reconstructed by an algorithm that measures the
Multiple Coulomb Scattering along the particle's path. Moreover, we show that
momentum resolution can be improved by a factor two using an algorithm based on
the Kalman Filtering technique
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