78 research outputs found
Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring
Objectives: To evaluate the feasibility and effectiveness of magnetic resonance (MR)-guided radiofrequency (RF) ablation for small liver tumours with poor conspicuity on both contrast-enhanced ultrasonography (US) and computed tomography (CT), using fast navigation and temperature monitoring. Methods: Sixteen malignant liver nodules (long-axis diameter, 0.6-2.4cm) were treated with multipolar RF ablation on a 1.5-T wide-bore MR system in ten patients. Targeting was performed interactively, using a fast steady-state free precession sequence. Real-time MR-based temperature mapping was performed, using gradient echo-echo planar imaging (GRE-EPI) and hardware filtering. MR-specific treatment data were recorded. The mean follow-up time was 19 ± 7months. Results: Correct placement of RF electrodes was obtained in all procedures (image update, <500ms; mean targeting time, 21 ± 11min). MR thermometry was available for 14 of 16 nodules (88%) with an accuracy of 1.6°C in a non-heated region. No correlation was found between the size of the lethal thermal dose and the ablation zone at follow-up imaging. The primary and secondary effectiveness rates were 100% and 91%, respectively. Conclusions: RF ablation of small liver tumours can be planned, targeted, monitored and controlled with MR imaging within acceptable procedure times. Temperature mapping is technically feasible, but the clinical benefit remains to be prove
Heterogeneous cavitation from atomically smooth liquid-liquid interfaces
Pressure reduction in liquids may result in vaporization and bubble
formation. This thermodynamic process is termed cavitation. It is commonly
observed in hydraulic machinery, ship propellers, and even in medical therapy
within the human body. While cavitation may be beneficial for the removal of
malign tissue, yet in many cases it is unwanted due to its ability to erode
nearly any material in close contact. Current understanding is that the origin
of heterogeneous cavitation are nucleation sites where stable gas cavities
reside, e.g., on contaminant particles, submerged surfaces or shell stabilized
microscopic bubbles. Here, we present the finding of a so far unreported
nucleation site, namely the atomically smooth interface between two immiscible
liquids. The non-polar liquid of the two has a higher gas solubility and acts
upon pressure reduction as a gas reservoir that accumulates at the interface.
We describe experiments that clearly reveal the formation of cavitation on
non-polar droplets in contact with water and elucidate the working mechanism
that leads to the nucleation of gas pockets through simulations.Comment: This preprint has not undergone peer review or any post-submission
improvements or corrections. The Version of Record of this article is
published in Nature Physics, and is available online at
https://doi.org/10.1038/s41567-022-01764-
Inter-fractional Respiratory Motion Modelling from Abdominal Ultrasound: A Feasibility Study
Motion management strategies are crucial for radiotherapy of mobile tumours in order to ensure proper target coverage, save organs at risk and prevent interplay effects. We present a feasibility study for an inter-fractional, patient-specific motion model targeted at active beam scanning proton therapy. The model is designed to predict dense lung motion information from 2D abdominal ultrasound images. In a pretreatment phase, simultaneous ultrasound and magnetic resonance imaging are used to build a regression model. During dose delivery, abdominal ultrasound imaging serves as a surrogate for lung motion prediction. We investigated the performance of the motion model on five volunteer datasets. In two cases, the ultrasound probe was replaced after the volunteer has stood up between two imaging sessions. The overall mean prediction error is 2.9 mm and 3.4 mm after repositioning and therefore within a clinically acceptable range. These results suggest that the ultrasound-based regression model is a promising approach for inter-fractional motion management in radiotherapy
Test
AbstractThis is a test to show that the uploaded resources are available by anyone onlin
Test yareta
AbstractThis is a test to show that the uploaded resources are available by anyone onlin
Boiling core animation
AbstractDynamic series of segmented EPI GRE magnitude data illustrating the occurrence and development of a macroscopic boiling point at the focus, perfused ex vivo kidney, transverse slice, in plane resolution 1 mm x 1 mm
Acoustic simulations prostate transducer
AbstractSimulations acoustiques du transducteur prostate faites début 2018 par OL pour déterminer rapidement les caractéristiques du futur HIFU prostate. Test rapide de faisabilité avant soumission FNS et discussion avec Fraunhofer IBMT
Computer-Aided Intra-Operatory Positioning of an MRgHIFU Applicator dedicated to Abdominal Thermal Therapy using Particle Swarm Optimization
AbstractThis document presents a novel software tool developed to optimize the positioning of a
high intensity focused ultrasound transducer (HIFU) dedicated to abdominal thermal
therapy
Computer-Aided Intra-Operatory Positioning
AbstractThis document presents a novel software tool developed to optimize the positioning of a high intensity focused ultrasound transducer (HIFU) dedicated to abdominal thermal therapy
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