The potential of metabolomics in the diagnosis of thyroid cancer

Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics

Exponential stability for a nonlinear porous-elastic system with delay

In this work, we consider the existence of global solution and the exponential decay of a nonlinear porous elastic system with time delay. The nonlinear term as well as the delay acting in the equation of the volume fraction. In order to obtain the existence and uniqueness of a global solution, we will use the semigroup theory of linear operators and under a certain relation involving the coefficients of the system together with a Lyapunov functional, we will establish the exponential decay of the energy associated to the system.Comment: Manuscript, 21 page

A randomized trial of the close reading and creative writing program: an alternative educational method for adult group care intervention in type 2 diabetes management

Objectives: Group care for individuals with diabetes is a recognized educational practice, but techniques from narrative medicine using of literary works have never been incorporated in these programs. We designed a new educational model (i.e. the Close Reading and Creative Writing program) of group care for individuals with diabetes incorporating close reading and creative writing in group education. A randomized trial was designed to evaluate this intervention. Methods: A total of 49 individuals with type 2 diabetes, aged 6 years of school education, were randomized to 2 different group care dynamics: (a) a “control group,” with a classical structured educational approach currently used at our institution; and (b) an “intervention group,” with introduction of literary texts, narrative skills, close reading and creative writing. Evaluation included anthropometric measures, glycated hemoglobin (A1C) and questionnaires for psychological evaluation. Individual A1C levels in the 6-year period before the trial were collected from clinical records. Results: A significant reduction of A1C was observed in the intervention group, showing noninferiority in relation to the classical approach. A significant decrease in A1C was observed in relation to the 6 previous years. A significant increase in satisfaction with the therapist and group process was observed. Conclusions: This is the first randomized trial designed to evaluate a group care intervention to manage type 2 diabetes using narrative techniques. The results suggest that this may be a useful model for more highly schooled individuals, and may represent an alternative for the educational process.info:eu-repo/semantics/acceptedVersio

Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor

Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing the patient's death. Epithelioid trophoblastic tumor, a rare form of gestational trophoblastic disease, is a recently described neoplasm whose cutaneous metastasis has not been previously reported in the literature

Avaliação de cultivares de arroz de sequeiro em diferentes épocas de plantio no Território Federal de Rondônia.

Procurou-se identificar cultivares mais produtivas em epocas de plantio mais favoraveis. Os experimentos foram conduzidos nos campos experimentais da EMBRAPA-UEPAT, em Porto Velho e Ouro Preto no periodo de 1976/77, em uma area total de 1.209,60m2. Usou-se o delineamento experimental de blocos casualizados, com tres repeticoes.Nao se conhecia espacamento ideal para o arroz,optando-se por 30 x 30cm. A densidade de plantio foi 5 a 6 sementes por cova, considerando-se a percentagem de germinacao de sementes na ordem de 82% a 95%. Os resultados demonstram que para Porto Velho, as cultivares IAC-1246, A-19, IAC-1131 e Pratao precoce (periodo ideal em fins de out., ate primeira quinzena de nov.), IAC-1246, A-19, IAC-1246 e IAC-1131 (apos segunda quinzena de nov. a inicio de dez.) mostraram-se mais satisfatoria, e com melhores condicoes em produtividade e outras caracteristicas para o agricultor e consumidor. Em Ouro Preto, se destacaram as cultivares IAC-1246(segunda quinzena de out.) e IAC-1131 (no final de nove., com colheita para fisnm de mar.). Sugere-se a continuidade de pesquisa a fim de substituir e introduzir cultivares mais produtivas e melhor adaptaveis.bitstream/item/49913/1/CT-id-11250001.pd