Field experiments synchronous with SRTM flights

A national coordinated program was evolved to utilise SRTM data for applications to Earth sciences, hydrology and technology development. The project was sponsored by Department of Science and Technology, Government of India. Fourteen test sites covering the above themes spread all over India were selected for conducting synchronous field experiments. About 52 corner reflectors (CR) were fabricated with two sizes (1.2 meters and 1.6 meters shortest length) and installed in the fields by the respective groups according to the installation parameters given by DLR, Germany. The CRs and GPS data will be useful for calibration of the SAR system and validation of DEM products. This paper gives the details of the field campaign.© IEE

Percutaneous endoscopic gastrostomy and gastro-oesophageal reflux in neurologically impaired children

AIM: To investigate the effects of percutaneous endoscopic gastrostomy (PEG) feeding on gastro-oesophageal reflux (GOR) in a group of these children using combined intraluminal pH and multiple intraluminal impedance (pH/MII)

Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer

Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype presents with an aggressive clinical course, heightened metastatic potential and the poorest short-term prognosis. TNBC does not respond to hormonal therapy, only partially responds to radio- and chemotherapy, and has limited targeted therapy options, thus underlining the critical need for better therapeutic treatments. Although immunotherapy based on immune checkpoint inhibition is emerging as a promising treatment option for TNBC patients, activation of cellular plasticity programs such as metabolic reprogramming (MR) and epithelial-to-mesenchymal transition (EMT) causes immunotherapy to fail. In this report, we review the role of MR and EMT in immune checkpoint dysregulation in TNBCs and specifically shed light on development of novel combination treatment modalities for this challenging disease. We highlight the clinical relevance of crosstalk between MR, EMT, and immune checkpoints in TNBCs