The single currency and European citizenship

We could expect that the introduction of the single currency had been accompanied by a significant share of studies and researches about the implications and impacts of such a watershed event on European citizenship. On the contrary, we soon discover to be facing a paradox, which could be phrased as follows: while the purpose of building European citizenship is the very rationale for the project of the single currency, the Scholars – but also the policy community – have mostly underestimated if not neglected this relation, both in terms of public policy making and discourse and of interpretation and forecasting. As a consequence of all of that, relevant features of the single currency happened to remain hidden, poorly considered and almost not thematized. In order to fill this gap, the first part of this article will present the main findings emerged from a documentary research conducted by FONDACA between 2010 and 2011, aimed at mapping the existing academic and policy thematizations about the hidden dimensions of the euro. The second part will be devoted to define “the other side of the coin” as an empirical phenomenon

Neutrino oscillations

In the last decades, a very important breakthrough has been brought in the elementary particle physics by the discovery of the phenomenon of the neutrino oscillations, which has shown neutrino properties beyond the Standard Model. But a full understanding of the various aspects of the neutrino oscillations is far to be achieved. In this paper the theoretical background of the neutrino oscillation phenomenon is described, referring in particular to the paradigmatic models. Then the various techniques and detectors which studied neutrinos from different sources are discussed, starting from the pioneering ones up to the detectors still in operation and to those in preparation. The physics results are finally presented adopting the same research path which has crossed this long saga. The problems not yet fixed in this field are discussed, together with the perspectives of their solutions in the near future

Organization of aerobactin, hemolysin, and antibacterial resistance genes in lactose negative Escherichia coli strains of serotype O4 isolated from children with dhiarrea

Epidemiologically related, non-lactose-fermenting (NLF) Escherichia coli strains of serotype O4 have been isolated at a high frequency from children with diarrhea in Somalia (M. Nicoletti, F. Superti, C. Conti, A. Calconi, and C. Zagaglia, J. Clin. Microbiol. 26:524-529, 1988). In order to define the virulence potential of these strains, we characterized the replication properties of their high-molecular-weight plasmids and studied the genetic locations and organization of the aerobactin (aer) and hemolysin (hly) determinants encoded by 23 NLF O4 E. coli strains. Southern blot hybridizations, mobilization assays of nonconjugative plasmids, and incompatibility-exclusion experiments conducted with a conjugative incompatibility group FI (IncFI) plasmid showed that (i) 20 out of the 23 strains examined harbor a 160- to 180-kb IncFI plasmid that shares homology with the basic replicons RepFIA, RepFIB, and (except for the plasmid of one strain) RepFIC, and 22 strains also contain a 40- to 140-kb IncFII plasmid sharing homology with the RepFIIA replicon; (ii) the IncFI plasmid is nonconjugative and carries antibiotic resistance genes; (iii) the aer system is located on the IncFI plasmids and/or the chromosomes in the three strains not harboring IncFI, and it is found in an inverted orientation; (iv) the hly determinants are located on the chromosome, and their genetic organization is well conserved and closely resembles that of the reference hemolytic plasmid pHly152; and (v) Hly- mutants obtained by transposon insertion mutagenesis are not cytotoxic to HeLa cell monolayers, indicating that hemolysin is responsible for the high cytotoxic activity we have previously reported for these strains. The structural organization of the plasmid-encoded aer operon, together with the finding that those plasmids also carry antibiotic resistance genes, indicates that the IncFI plasmid of the NLF O4 E. coli strains studied more closely resembles aer-encoding virulence IncFI Salmonella R plasmids than E. coli ColV plasmids. The data presented here cannot rule out whether the strains examined are potentially intestinal or extraintestinal pathogens. Nevertheless, the genetic organization of the virulence genes, together with the epidemiological behavior and the wide spectrum of antibiotic resistance of the NLF O4 E. coli strains, indicates that these strains are structured as typical E. coli pathogenic isolates of human origin

Present and Future Contributions of Reactor Experiments to Mass Ordering and Neutrino Oscillation Studies

After a long a glorious history, marked by the first direct proofs of neutrino existence and of the mixing between the first and third neutrino generations, the reactor antineutrino experiments are still well alive and will continue to give important contributions to the development of elementary particle physics and astrophysics. In parallel to the SBL (short baseline) experiments, that will be dedicated mainly to the search for sterile neutrinos, a new kind of experiments will start playing an important role: reactor experiments with a \u201cmedium\u201d value, around 50 km, of the baseline, somehow in the middle between the SBL and the LBL (long baselines), like KamLAND, which in the recent past gave essential contributions to the developments of neutrino physics. These new medium baseline reactor experiments can be very important, mainly for the study of neutrino mass ordering. The first example of this kind, the liquid scintillator JUNO experiment, characterized by a very high mass and an unprecedented energy resolution, will soon start data collecting in China. Its main aspects are discussed here, together with its potentialities for what concerns the mass ordering investigation and also the other issues that can be studied with this detector, spanning from the accurate oscillation parameter determination to the study of solar neutrinos, geoneutrinos, atmospheric neutrinos and neutrinos emitted by supernovas and to the search for signals of potential Lorentz invariance violation

Validation of viscoelastic coagulation tests during cardiopulmonary bypass: comment

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Differences in chemical, physical and microbiological characteristics of Italian burrata cheeses made in artisanal and industrial plants of Apulia Region

The burrata cheese is a traditional product from Southern Italy, consisting of an envelope of pasta filata (stretched curd) filled with cream and pasta filata strips (usually leftovers from mozzarella production). Physical [water activity (aw), pH], chemical (moisture, NaCl content) and microbiological [total viable count (TVC), Listeria monocytogenes, Salmonella spp., Yersinia enterocolitica, Bacillus cereus, Escherichia coli, Enterobacteriaceae, coagulase-positive staphylococci] characteristics of burrata cheeses manufactured in artisanal and industrial plants were evaluated. The artisanal burrata showed lower aw values in the filling and the final product. The same was recorded in the filling for the moisture, probably due to differences between the types of cream used in the artisanal and the industrial cheesemaking. The pH value of the filling differed between the two groups but no difference was recorded in the final product. Microbiological differences were also recorded, with higher values for TVC and E. coli in artisanal than industrial burrata. All samples were negative for the other microbialdeterminations, with the exception of coagulase-positive staphylococci and Y. enterocolitica, which were detected in artisanal burrata. Differences in cheesemaking process were probably responsible for the strong variability of the physical and chemical data between the two cheeses; furthermore, differences in the hygienic features were also recorded. Even though artisanal products showed lower aw and pH values and higher NaCl concentration, the higher E. coli loads highlighted the need for a more accurate compliance with hygienic procedures along the artisanal cheesemaking process

Tuning Polyamidoamine Design to Increase Uptake and Efficacy of Ruthenium Complexes for Photodynamic Therapy

Nanomedicine holds great promises to change the way drugs are delivered to their target, owing to the use of nano-sized drug carriers capable to enter cells and be trafficked intracellularly via energy dependent pathways [1, 2]. This is very different from the way most drugs arrive to their target, often based simply on their solubility and partition coefficients in lipids and water. Despite some valuable successes, drug delivery remains rather challenging and several factors are still limiting its potential. Among such factors, it has emerged, for instance, that most nano-sized carriers entering cells via endocytosis are later trafficked along the endolysosomal pathway to the lysosomes, where the low pH and abundant proteases can degrade and destroy the internalised cargo. Strategies to escape the endosomes and lysosomes are being investigated. Among the many polymer species employed as drug delivery vectors, linear polyamidoamines (PAAs) are very interesting and promising materials. In this communication it will be presented a new polycationic PAA endowed with a luminescent Ru complex (Ru-PhenAN) and its ability to target the cell nucleus. It shows unique trafficking to the cell nucleus of all the treated cells, also at polymer doses as low as cytotoxicity is very low. Also, it will be shown the efficacy of Ru-PhenAN as photosensitizers for photodynamic therapy (PDT), a treatment of pathological conditions based on the photo-activation of a bioactive compound, which is not harmful in the absence of light irradiation [3]