White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored the relationship between WMH on computerised tomography (CT) and white coat hypertension/effect (WCH/E) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Design and method: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Twenty-three patients had normotension (clinic BP / = 140/90mmHg and day-time ABPM < 135/85mmHg). Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV) (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI) (VaSera VS-1500N®, Fukuda Denshi). CT images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP, vascular stiffness and WMH was explored with t-tests, chi-square and logistic regression accounting for known cardiovascular risk factors. Results: Forty-four percent of patients with WCH/E had moderate-severe WMH compared to 17% of normotensives (p = 0.047). The regression model with WMH as the dependent factor, and WCH/E and cardiovascular risk factors as independent factors showed WCH/E and either CAVI or PWV to be the only independent significant factor contributing to WMH (CAVI:p = 0.038, PWV:p = 0.043)

The effect of milk on recovery from repeat-sprint cycling in female team-sport athletes

The consumption of milk post-eccentric exercise attenuates the effects of muscle damage in team-sport athletes. However, participation in team sport involves both concentric-eccentric loading and metabolic stress. Therefore, the aim of this study was to investigate the effects of post-exercise milk consumption on recovery from a cycling protocol designed to simulate the metabolic demands of team sport. Ten female team-sport athletes participated in a randomised cross-over investigation. Upon completion of the protocol participants consumed 500ml of milk (MILK) or 500ml of an energy-matched carbohydrate (CHO) drink. Muscle function (peak torque, rate of force development (RFD), countermovement jump (CMJ), 20m sprint, muscle soreness and tiredness, serum creatine kinase (CK), (high-sensitivity C reactive protein (hsCRP) and measures of oxidative stress (protein carbonyls (PC) and GSH:GSSG (oxidized glutathione:reduced glutathione) ratio) were determined pre-, 24h, 48h and 72h post-exercise. MILK had a possible beneficial effect in attenuating losses in peak torque (180 s) from baseline to 24h (3.2±7.8% v -6.2±7.5%, MILK v CHO) and a possible beneficial effect in minimising soreness (baseline-48h; baseline-72h) and tiredness (baseline-24h; baseline-72h). There was no change in oxidative stress following the exercise protocol, though a likely benefit of milk was observed for GSH:GSSH ratio at baseline-24h (0.369 x/÷ 1.89, 1.103 x/÷ 3.96, MILK v CHO). MILK had an unclear effect on all other variables. Consumption of 500ml milk post-repeat sprint cycling had little to no benefit in minimising losses in peak torque, or minimising increases in soreness and tiredness and had no effect on serum markers of muscle damage and inflammation

Incorporating Poly(3-hexyl thiophene) into Orthogonally Aligned Cylindrical Nanopores of Titania for Optoelectronics

The incorporation of hole conducting polymer poly(3-hexyl thiophene) (P3HT) into the 8-9 nm cylindrical nanopores of titania is investigated using films with a unique orthogonally oriented hexagonal close packed mesostructure. The films are synthesized using evaporation induced self-assembly (EISA) with Pluronic triblock copolymer F127 as the structure directing agent. The orthogonally oriented cylindrical nanopore structure was chosen over a cubic structure because confinement in uniform cylindrical channels is hypothesized to enhance hole conductivity of P3HT by inducing local polymer chain ordering. Orthogonal orientation of the cylindrical nanopores is achieved by modifying the substrate (FTO-coated glass slides) with crosslinked F127. After thermal treatment to remove organic templates from the films, P3HT is infiltrated into the nanopores by spin coating a 1 wt% P3HT solution in chlorobenzene onto the titania films followed by thermal annealing under vacuum at 200 °C. The results show that infiltration is essentially complete after 30 minutes of annealing, with little or no further infiltration thereafter. A final infiltration depth of ~14 nm is measured for P3HT into the nanopores of titania using neutron reflectometry measurements. Photoluminescence measurements demonstrate that charge transfer at the P3HT-TiO2 interface improves as the P3HT is infiltrated into the pores, suggesting that an active organic-inorganic heterojuction is formed in the materials

Coherently Dedispersed Polarimetry of Millisecond Pulsars

We present a large sample of high-precision, coherently-dedispersed polarization profiles of millisecond pulsars (MSPs) at frequencies between 410 and 1414 MHz. These data include the first polarimetric observations of several of the pulsars, and the first low-frequency polarization profiles for others. Our observations support previous suggestions that the pulse shapes and polarimetry of MSPs are more complex than those of their slower relatives. An immediate conclusion is that polarimetry-based classification schemes proposed for young pulsars are of only limited use when applied to millisecond pulsars.Comment: 28 pages, 10 figures. Text matches version that appeared in ApJS. Full paper with high-resolution figures available at ftp://ftp.jb.man.ac.uk/pub/psr/papers/msppolpton.ps.g

Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior

OBJECTIVES: Childhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral memory (OGM). Altered ABM and OGM have been linked with psychopathology and poorer social functioning. The present study investigated the association between altered ABM and subsequent socio-emotional functioning (measured two years later) in a sample of adolescents with (N = 20; maltreatment group, MT) and without (N = 17; non-MT group) documented childhood maltreatment histories. METHOD: At baseline, adolescents (aged 12.6 ± 1.45 years) were administered the Autobiographical Memory Test to measure OGM. Participants also recalled specific ABMs in response to emotionally valenced cue words during functional MRI. Adolescents in both groups underwent assessments measuring depressive symptoms and prosocial behavior at both timepoints. Regression analyses were carried out to predict outcome measures at follow-up controlling for baseline levels. RESULTS: In the MT group, greater OGM at baseline significantly predicted reduced prosocial behavior at follow-up and showed a trend level association with elevated depressive symptoms. Patterns of altered ABM-related brain activity did not significantly predict future psycho-social functioning. CONCLUSIONS: The current findings highlight the potential value of OGM as a cognitive mechanism that could be targeted to reduce risk of depression in adolescents with prior histories of maltreatment

Deciphering the folding kinetics of transmembrane helical proteins

Nearly a quarter of genomic sequences and almost half of all receptors that are likely to be targets for drug design are integral membrane proteins. Understanding the detailed mechanisms of the folding of membrane proteins is a largely unsolved, key problem in structural biology. Here, we introduce a general model and use computer simulations to study the equilibrium properties and the folding kinetics of a $C_{\alpha}$-based two helix bundle fragment (comprised of 66 amino-acids) of Bacteriorhodopsin. Various intermediates are identified and their free energy are calculated toghether with the free energy barrier between them. In 40% of folding trajectories, the folding rate is considerably increased by the presence of non-obligatory intermediates acting as traps. In all cases, a substantial portion of the helices is rapidly formed. This initial stage is followed by a long period of consolidation of the helices accompanied by their correct packing within the membrane. Our results provide the framework for understanding the variety of folding pathways of helical transmembrane proteins

PSR 0943+10: a bare strange star?

Recent work by Rankin & Deshpande strongly suggests that there exist strong ``micro-storms'' rotating around the magnetic axis of the 1.1s pulsar PSR 0943+10. Such a feature hints that most probably the large-voltage vacuum gap proposed by Ruderman & Sutherland (RS) does exist in the pulsar polar cap. However, there are severe arguments against the formation of the RS-type gap in pulsars, since the binding energies of both the Fe ions and the electrons in a neutron star's surface layer is too small to prevent thermionic ejection of the particles from the surface. Here we propose that PSR 0943+10 (probably also most of the other ``drifting'' pulsars) might be bare strange stars rather than normal neutron stars, in which the ``binding energy'' at the surface is merely infinity either for the case of ``pulsar'' or ``anti-pulsar''. It is further proposed that identifying a drifting pulsar as an anti-pulsar is the key criterion to distinguish strange stars from neutron stars.Comment: 4 pages, no figures, LaTeX, accepted 1999 July 9 by ApJ Letter

The Quantum Modular Group in (2+1)-Dimensional Gravity

The role of the modular group in the holonomy representation of (2+1)-dimensional quantum gravity is studied. This representation can be viewed as a "Heisenberg picture", and for simple topologies, the transformation to the ADM "Schr{\"o}dinger picture" may be found. For spacetimes with the spatial topology of a torus, this transformation and an explicit operator representation of the mapping class group are constructed. It is shown that the quantum modular group splits the holonomy representation Hilbert space into physically equivalent orthogonal ``fundamental regions'' that are interchanged by modular transformations.Comment: 23 pages, LaTeX, no figures; minor changes and clarifications in response to referee (basic argument and conclusions unaffected

Distribution of Eigenvalues for the Modular Group

The two-point correlation function of energy levels for free motion on the modular domain, both with periodic and Dirichlet boundary conditions, are explicitly computed using a generalization of the Hardy-Littlewood method. It is shown that ion the limit of small separations they show an uncorrelated behaviour and agree with the Poisson distribution but they have prominent number-theoretical oscillations at larger scale. The results agree well with numerical simulations.Comment: 72 pages, Latex, the fiogures mentioned in the text are not vital, but can be obtained upon request from the first Autho

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.

The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes. Weaver syndrome is a human overgrowth condition characterised by tall stature, dysmorphic facial features, learning disability and variable additional features. We performed exome sequencing in four individuals with Weaver syndrome, identifying a mutation in the histone methyltransferase, EZH2, in each case. Sequencing of EZH2 in additional individuals with overgrowth identified a further 15 mutations. The EZH2 mutation spectrum in Weaver syndrome shows considerable overlap with the inactivating somatic EZH2 mutations recently reported in myeloid malignancies. Our data establish EZH2 mutations as the cause of Weaver syndrome and provide further links between histone modifications and regulation of human growth