Use of Contraceptives and Unmet Need for Family Planning among Tribal Women in India and Selected Hilly States

The paper provides a comprehensive picture of knowledge and use of contraceptives among scheduled tribes of India and selected central hilly states where tribal population contributes more than 30% of the total tribal population of the country. An attempt is also made to know how far scheduled tribes differ from non-tribes in the states, namely Jharkhand, Madhya Pradesh, and Chhattisgarh, using information collected in the third round of District-level Household Survey (DLHS-RCH III: 2007-2008). Bivariate analysis was used for understanding the level of knowledge, use of and unmet need for contraception among different tribal and non-tribal groups. Binary logistic regression was used for understanding the factors associated with the use of contraception and unmet need for family planning among tribal women. Knowledge and use of temporary contraceptive methods are considerably lower among tribal women compared to their non-tribal counterparts in the three states under study. Low acceptance due to phobia of adverse health consequences, accessibility to and lack of sound knowledge of contraception are the leading reasons for not using contraceptives. The unmet need for family planning among them was quite high, especially in the state of Jharkhand. Multivariate analysis substantiated the role of women and husbands\u2019 education, age of women, and number of surviving boys in the use of any modern method of contraception. Educating women and their respective husbands about proper use and benefits of modern contraceptives is important to solve the problem of high unmet need for family planning among these tribal women. A simultaneous attention to the health systems strengthening component is crucial for ensuring sustained delivery of good-quality family planning services

Overweight and Obesity among Women by Economic Stratum in Urban India

Using data of the third round of the National Family Health Survey (NFHS) 2005-2006, this study examined the prevalence of overweight and obesity among women from different economic strata in urban India. The study used a separate wealth index for urban India constructed using principal components analysis (PCA). The result shows that prevalence of overweight and obesity is very high in urban areas, more noticeably among the non-poor households. Furthermore, overweight and obesity increase with age, education, and parity of women. The results of multinomial logistic regression show that non-poor women are about 2 and 3 times more at risk of being overweight and obese respectively. Marital status and media exposure are the other covariates associated positively with overweight and obesity. Thus, the growing demand which now appears before the Government or urban health planners is to address this rising urban epidemic with equal importance as given to other issues in the past

The human YAE1-ORAOV1 complex of the cytosolic iron-sulfur protein assembly machinery binds a [4Fe-4S] cluster

Abstract Iron-sulfur (Fe-S) clusters are among the most versatile cofactors in biology. Although Fe-S clusters formation can be achieved spontaneously in vitro with inorganic iron and sulfur sources, the in vivo behaviour is more complex and requires the so-called Fe-S biogenesis machineries. In the cytosol, the biogenesis of Fe-S proteins is assisted by the cytosolic Fe-S protein assembly machinery, which comprises at least thirteen known proteins, among which there are human ORAOV1 and YAE1. A hetero-complex formed by the two latter proteins facilitates Fe-S cluster insertion in the human ABC protein ABCE1 within a chain of binding events that are still not well understood. In the present work, ORAOV1 and the YAE1-ORAOV1 complex were produced and their structural and cluster binding properties spectroscopically investigated. It resulted that both ORAOV1 and the YAE1-ORAOV1 complex are characterized by well-structured, α -helical regions and by unstructured, flexible regions, and are both able to bind a [4Fe-4S]2+ cluster. Bioinformatics and site-directed mutagenesis studies indicated that the [4Fe-4S] cluster in ORAOV1 is bound by a conserved cluster binding motif, while YAE1, which does not have a metal-binding consensus motif, is not essential for the [4Fe-4S]2+ cluster binding in the YAE1-ORAOV1 hetero-complex. Overall, these results support a model that the YAE1-ORAOV1 complex might actively participate in the Fe-S cluster insertion into ABCE1 thanks to the [4Fe-4S]2+ cluster binding properties of ORAOV1

COMPARATIVE EFFECT OF KSHARASUTRA ON MANAGEMENT OF BHAGANDARA

Bhagandara is a chronic purulent inflammation usually affects perianal region, anal canal and rectum. It initially manifested by an abscess followed by continuous discharge of pus through the tract and leads to an unhealed condition. Improper care and negligence to the disease lead the patient to seriousness occasionally. Now-a-days, management of Bhagandara with Ksharasutra is gained popularity for its minimal invasive and complete cure of the disease but corrosiveness and pain during application of Ksharasutra still remain as a drawback to the approach.  This study includes preparation of three types of Ksharasutra and comparative effect of Ksharasutra in the management of Bhagandara. Considering the above problem a thorough review was done in order to find out any solution to solve the purpose of Ksharasutra without pain. Further, it is also revealed that the corrosive agent usually in the preparation of ksharasutra is Snuhi ksheera (Euphorbia nerifolia). The relevant study proved that ksharasutra can also be prepared with Guggulu (Comiphora mukulu) and Udumbara latex (Ficus glomerata) instead of Snuhi ksheera. Thus evaluation of the effect of such Ksharasutra is not methodically done yet. In order to evaluate the effects of ksharasutra prepared out of Guggulu and Udumbara latex is selected for the purpose of the study

Globulin seed storage protein based genotyping and Study of genetic diversity in core accessions of mungbean under drought stress

Globulin seed storage protein profiles of 19 mungbean genotypes including two wild forms of Vigna radiata var. sublobata(TCR 20 and TCR 213) and two standard  checks(T 2-1 and LGG 460) were analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Thirteen genotypes could be clearly identified based on genotype-specific seed protein fingerprints. The combined dendrogram showed six genetic clusters within 68% phenon level. The clustering based on the combined clustering analysis revealed discrimination of all test genotypes even immediately beyond 88% phenon level, whereas individual clustering analysis based on protein and agro-morphological level failed to do so. Nipania munga, TCR 213, T 2-1, LGG 460, TCR 20 and Banapur local B were identified to be highly divergent genotypes. TCR 20 appears to have more genetic proximity to the mungbean genotypes than TCR 213. T 2-1, LGG 460 and TCR 20 are potentially high yielding. These may serve as valuable materials for recombination breeding in mungbean

Challenges and opportunities in mixed method data collection on mental health issues of health care workers during COVID-19 pandemic in India

Background: The present paper describes the key challenges and opportunities of mixed method telephonic data collection for mental health research using field notes and the experiences of the investigators in a multicenter study in ten sites of India. The study was conducted in public and private hospitals to understand the mental health status, social stigma and coping strategies of different healthcare personnel during the COVID-19 pandemic in India.Methods: Qualitative and quantitative interviews were conducted telephonically. The experiences of data collection were noted as a field notes/diary by the data collectors and principal investigators.Results: The interviewers reported challenges such as network issues, lack of transfer of visual cues and sensitive content of data. Although the telephonic interviews present various challenges in mixed method data collection, it can be used as an alternative to face-to-face data collection using available technology.Conclusions: It is important that the investigators are well trained keeping these challenges in mind so that their capacity is built to deal with these challenges and good quality data is obtained

Factors associated with stigma and manifestations experienced by Indian health care workers involved in COVID-19 management in India: A qualitative study

Healthcare personnel who deal with COVID-19 experience stigma. There is a lack of national-level representative qualitative data to study COVID-19-related stigma among healthcare workers in India. The present study explores factors associated with stigma and manifestations experienced by Indian healthcare workers involved in COVID-19 management. We conducted in-depth interviews across 10 centres in India, which were analysed using NVivo software version 12. Thematic and sentiment analysis was performed to gain deep insights into the complex phenomenon by categorising the qualitative data into meaningful and related categories. Healthcare workers (HCW) usually addressed the stigma they encountered when doing their COVID duties under the superordinate theme of stigma. Among them, 77.42% said they had been stigmatised in some way. Analyses revealed seven interrelated themes surrounding stigma among healthcare workers. It can be seen that the majority of the stigma and coping sentiments fall into the mixed category, followed by the negative sentiment category. This study contributes to our understanding of stigma and discrimination in low- and middle-income settings. Our data show that the emergence of fear of the virus has quickly turned into a stigma against healthcare workers

Using an equity-based framework for evaluating publicly funded health insurance programmes as an instrument of UHC in Chhattisgarh State, India

Universal health coverage (UHC) has provided the impetus for the introduction of publicly funded health insurance (PFHI) schemes in the mixed health systems of India and many other low- and middle-income countries. There is a need for a holistic understanding of the pathways of impact of PFHI schemes, including their role in promoting equity of access. Methods: This paper applies an equity-oriented evaluation framework to assess the impacts of PFHI schemes in Chhattisgarh State by synthesising literature from various sources and highlighting knowledge gaps. Data were collected from an extensive review of publications on PFHI schemes in Chhattisgarh since 2009, including empirical studies from the first author's PhD and grey literature such as programme evaluation reports, media articles and civil society campaign documents. The framework was constructed using concepts and frameworks from the health policy and systems research literature on UHC, access and health system building blocks, and is underpinned by the values of equity, human rights and the right to health