HST emission-line images of nearby 3CR radio galaxies: two photoionization, accretion and feedback modes

We present HST/ACS narrow-band images of a low-z sample of 19 3C radio galaxies to study the H$\alpha$ and [OIII] emissions from the narrow-line region (NLR). Based on nuclear emission line ratios, we divide the sample into High and Low Excitation Galaxies (HEGs and LEGs). We observe different line morphologies, extended line emission on kpc scale, large [OIII]/H$\alpha$ scatter across the galaxies, and a radio-line alignment. In general, HEGs show more prominent emission line properties than LEGs: larger, more disturbed, more luminous, and more massive regions of ionized gas with slightly larger covering factors. We find evidence of correlations between line luminosities and (radio and X-ray) nuclear luminosities. All these results point to a main common origin, the active nucleus, which ionize the surrounding gas. However, the contribution of additional photoionization mechanism (jet shocks and star formation) are needed to account for the different line properties of the two classes. A relationship between the accretion, photoionization and feedback modes emerges from this study. For LEGs (hot-gas accretors), the synchrotron emission from the jet represents the main source of ionizing photons. The lack of cold gas and star formation in their hosts accounts for the moderate ionized-gas masses and sizes. For HEGs (cold-gas accretors), an ionizing continuum from a standard disk and shocks from the powerful jets are the main sources of photoionization, with the contribution from star formation. These components, combined with the large reservoir of cold/dust gas brought from a recent merger, account for the properties of their extended emission-line regions.Comment: accepted for publication on ApJ (22 pages, 12 figures

Effects of compost age on the release of nutrients

Composted organic materials are applied to help restore disturbed soils, speed revegetation, and control erosion; these changes are generally beneficial for stormwater quality. Ensuring that nutrient release from compost is adequate for plant needs without degrading stormwater quality is important since composts release nitrogen at variable rates (1–3% of total N/yr) and the leaching process can extend for many years. The aim of this work was to understand the effect of compost age on the extent and rates of nitrogen release by conducting detailed rainfall simulation studies of one compost type at three different ages. Models describing temporal changes in nitrogen release to runoff during a single storm and across multiple storms were developed and applied to the runoff data. Nitrogen content (%) and bulk density of compost increased with the increase in compost age and total nitrogen release decreased with increasing compost age. The three rain simulations (storms) performed on each of the three compost ages show that nitrogen release declined each day of the repeated daily storms. A first-order kinetic model was used to estimate the amount of nitrogen remaining on compost after several storms

Lithographically and electrically controlled strain effects on anisotropic magnetoresistance in (Ga,Mn)As

It has been demonstrated that magnetocrystalline anisotropies in (Ga,Mn)As are sensitive to lattice strains as small as 10^-4 and that strain can be controlled by lattice parameter engineering during growth, through post growth lithography, and electrically by bonding the (Ga,Mn)As sample to a piezoelectric transducer. In this work we show that analogous effects are observed in crystalline components of the anisotropic magnetoresistance (AMR). Lithographically or electrically induced strain variations can produce crystalline AMR components which are larger than the crystalline AMR and a significant fraction of the total AMR of the unprocessed (Ga,Mn)As material. In these experiments we also observe new higher order terms in the phenomenological AMR expressions and find that strain variation effects can play important role in the micromagnetic and magnetotransport characteristics of (Ga,Mn)As lateral nanoconstrictions.Comment: 11 pages, 4 figures, references fixe

Soil erosion evaluation in a small watershed in Brazil through 137 Cs fallout redistribution analysis and conventional models

An investigation of rates and patterns of soil erosion on agricultural land cultivated with sugarcane was undert a ken using the 137Cs technique, USLE (Universal Soil Loss Equation) and WEPP (Water Erosion Prediction Project) model. The study was carried out on a representative catchment of a small watershed of the Piracicaba river basin, State of São Paulo, Brazil, called Ceveiro watershed, well known for its severe soil degradation caused by erosion. The results from the 137Cs technique indicate that most part of the studied area (94%) are eroded at erosion rates that go up to 59 Mg ha-1 y-1, with a weighted average rate of 23 Mg ha-1 y-1 . The weighted average rate of infield deposition and sediment retrieval that occurs in only 6% of the total area was estimated to be around 12 Mg ha-1 y-1 . These values led to very high net soil loss from the field, with rates of the order of 21 Mg ha-1 y-1 , which represents a sediment delive ry ratio of 97%. A linear correlation between soil erosion rate estimated by the 137Cs technique and the amount of available K in the top soil layer (0-20 cm) was observed. Based on this correlation the estimated amounts of net and gross K loss in the grid area due to soil erosion were of 0.2 and 1.52 kg ha-1 y-1, respectively. The erosion rate estimated by USLE was 39 Mg ha-1 y-1 and by WEPP model 16.5 Mg ha-1 y-1 with a sediment delivery of 12.4 Mg ha-1 y-1 (75%). The results are a confirmation that the soil conservation practices adopted in the area are very poor and can explain the high siltation level of water reservoirs in the watershed

Stem cell transplantation for ischemic stroke

Background Stroke is a leading cause of morbidity and mortality worldwide, with very large healthcare and social costs, and a strong demand for alternative therapeutic approaches. Preclinical studies have shown that stem cells transplanted into the brain can lead to functional improvement. However, to date, evidence for the benefits of stem cell transplantation in people with ischemic stroke is lacking. This is the first update of the Cochrane review published in 2010. Objectives To assess the efficacy and safety of stem cell transplantation compared with control in people with ischemic stroke. Search methods We searched the Cochrane Stroke Group Trials Register (last searched August 2018), CENTRAL (last searched August 2018), MED-LINE (1966 to August 2018), Embase (1980 to August 2018), and BIOSIS (1926 to August 2018). We handsearched potentially relevant conference proceedings, screened reference lists, and searched ongoing trials and research registers (last searched August 2018). We also contacted individuals active in the field and stem cell manufacturers (last contacted August 2018). Selection criteria We included randomized controlled trials (RCTs) that recruited people with ischemic stroke, in any phase of the disease (acute, subacute or chronic), and an ischemic lesion confirmed by computerized tomography or magnetic resonance imaging scan. We included all types of stem cell transplantation, regardless of cell source (autograft, allograft, or xenograft; embryonic, fetal, or adult; from brain or other tissues), route of cell administration (systemic or local), and dosage. The primary outcome was efficacy (assessed as neurologic impairment or functional outcome) at longer term follow-up (minimum six months). Secondary outcomes included post-procedure safety outcomes (death, worsening of neurological deficit, infections, and neoplastic transformation). Data collection and analysis Two review authors independently applied the inclusion criteria, assessed trial quality and risk of bias, and extracted data. If needed, we contacted study authors for additional information. We performed random effects meta-analyses when two or more RCTs were available for any outcome. We assessed the certainty of the evidence by using the GRADE approach. Main results In this updated review, we included seven completed RCTs with 401 participants. All tested adult human non-neural stem cells; cells were transplanted during the acute, subacute, or chronic phase of ischemic stroke; administered intravenously, intra-arterially, intracerebrally, or into the lumbar subarachnoid space. Follow-up ranged from six months to seven years. Efficacy outcomes were measured with the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), or Barthel Index (BI). Safety outcomes included case fatality, and were measured at the end of the trial. Overall, stem cell transplantation was associated with a better clinical outcome when measured with the NIHSS (mean difference [MD]-1.49, 95% confidence interval [CI]-2.65 to-0.33; five studies, 319 participants; low-certainty evidence), but not with the mRS (MD-0.42, 95% CI-0.86 to 0.02; six studies, 371 participants; very low-certainty evidence), or the BI (MD 14.09, 95% CI-1.94 to 30.13; three studies, 170 participants; very low-certainty evidence). The studies in favor of stem cell transplantation had, on average, a higher risk of bias, and a sample size of 32 or fewer participants. No significant safety concerns associated with stem cell transplantation were raised with respect to death (risk ratio [RR] 0.66, 95% CI 0.39 to 1.14; six studies, participants; low-certainty evidence). We were not able to perform the sensitivity analysis according to the quality of studies, because all of them were at high risk of bias. Authors’ conclusions Overall, in participants with ischemic stroke, stem cell transplantation was associated with a reduced neurological impairment, but not with a better functional outcome. No obvious safety concerns were raised. However, these conclusions came mostly from small RCTs with high risk of bias, and the certainty of the evidence ranged from low to very low. More well-designed trials are needed

Voltage control of magnetocrystalline anisotropy in ferromagnetic - semiconductor/piezoelectric hybrid structures

We demonstrate dynamic voltage control of the magnetic anisotropy of a (Ga,Mn)As device bonded to a piezoelectric transducer. The application of a uniaxial strain leads to a large reorientation of the magnetic easy axis which is detected by measuring longitudinal and transverse anisotropic magnetoresistance coefficients. Calculations based on the mean-field kinetic-exchange model of (Ga,Mn)As provide microscopic understanding of the measured effect. Electrically induced magnetization switching and detection of unconventional crystalline components of the anisotropic magnetoresistance are presented, illustrating the generic utility of the piezo voltage control to provide new device functionalities and in the research of micromagnetic and magnetotransport phenomena in diluted magnetic semiconductors.Comment: Submitted to Physical Review Letters. Updates version 1 to include a more detailed discussion of the effect of strain on the anisotropic magnetoresistanc

SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), first emerged in Wuhan, China. The clinical manifestations of patients infected with COVID-19 include fever, cough, and dyspnea, up to acute respiratory distress syndrome (ARDS) and acute cardiac injury. Thus, a lot of severe patients had to be admitted to intensive care units (ICU). The pathogenic mechanisms of SARS-CoV-2 infection are mediated by the binding of SARS-CoV-2 spikes to the human angiotensin-converting enzyme 2 (ACE-2) receptor. The overexpression of human ACE-2 is associated with the disease severity in SARS-CoV-2 infection, demonstrating that viral entry into cells is a pivotal step. Although the lung is the organ that is most commonly affected by SARS-CoV-2 infection, acute kidney injury (AKI), heart dysfunction and abdominal pain are the most commonly reported co-morbidities of COVID-19. The occurrence of AKI in COVID-19 patients might be explained by several mechanisms that include viral cytopathic effects in renal cells and the host hyperinflammatory response. In addition, kidney dysfunction could exacerbate the inflammatory response started in the lungs and might cause further renal impairment and multi-organ failure. Mounting recent evidence supports the involvement of cardiovascular complications and endothelial dysfunction in COVID-19 syndrome, in addition to respiratory disease. To date, there is no vaccine, and no specific antiviral medicine has been shown to be effective in preventing or treating COVID-19. The removal of pro-inflammatory cytokines and the shutdown of the cytokine storm could ameliorate the clinical outcome in severe COVID-19 cases. Therefore, several interventions that inhibit viral replication and the systemic inflammatory response could modulate the severity of the renal dysfunction and increase the probability of a favorable outcome

Desmopressin Stimulates Nitric Oxide Production in Human Lung Microvascular Endothelial Cells

Desmopressin (dDAVP) is the best characterized analogue of vasopressin, the endocrine regulator of water balance endowed with potent vasoconstrictive effects. Despite the use of dDAVP in clinical practice, ranging from the treatment of nephrogenic diabetes insipidus to bleeding disorders, much remains to be understood about the impact of the drug on endothelial phenotype. The aim of this study was, thus, to evaluate the effects of desmopressin on the viability and function of human pulmonary microvascular endothelial cells (HLMVECs). The results obtained demonstrate that the vasopressor had no cytotoxic effect on the endothelium; similarly, no sign of endothelial activation was induced by dDAVP, indicated by the lack of effect on the expression of inflammatory cytokines and adhesion molecules. Conversely, the drug significantly stimulated the production of nitric oxide (NO) and the expression of the inducible isoform of nitric oxide synthase, NOS2/iNOS. Since the intracellular level of cAMP also increased, we can hypothesize that NO release is consequent to the activation of the vasopressin receptor 2 (V2R)/guanylate cyclase (Gs)/cAMP axis. Given the multifaceted role of NOS2-deriving NO for many physio-pathological conditions, the meanings of these findings in HLMVECs appears intriguing and deserves to be further addressed