Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus

A dysregulated growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is well-recognized in children and adolescents with type 1 diabetes mellitus (T1DM). Decreased IGF-1 levels can also be found in chronic inflammatory diseases, while hyperglycemia promotes inflammatory cytokine production. Therefore, inflammatory cytokines may link poor metabolic control with GH/IGF-1 axis changes. This study examined the relationship between serum inflammatory cytokines and IGF-1 in adolescents (age 13–18) with TIDM in chronic poor (n=17) or favorable (n=19) glucose control. Poor control (PC) was defined as ≥ 3, consistent HbA1C > 9% during the previous 2 years, while favorable control (FC) was consistent levels of HbA1C < 9%

Metabolic control and bone health in adolescents with type 1 diabetes

<p>Abstract</p> <p>Background</p> <p>Adults with type 1 diabetes (T1D) have decreased bone mineral density (BMD) and increased fracture risk, yet the etiologies remain elusive. Early detection of derangements in bone biomarkers during adolescence could lead to timely recognition. In adolescents with T1D, we evaluated the relationships between metabolic control, BMD, and bone anabolic and turnover markers.</p> <p>Methods</p> <p>Cross-sectional study of 57 adolescent subjects with T1D who had HbA1c consistently ≥ 9% (Poor Control, PC n = 27) or < 9% (Favorable Control, FC n = 30) for two years prior to enrollment. Subjects had T1DM for at least three years and were without diabetes complications, known celiac disease, or other chronic diseases.</p> <p>Results</p> <p>There were no differences between HbA1c groups in BMD, components of the IGF system, or 25-hydroxyvitamin D status. The prevalence of 25-hydroxyvitamin D abnormalities was similar to that seen in the general adolescent population. Few patients met the recommended dietary allowance (RDA) for vitamin D or calcium.</p> <p>Conclusions</p> <p>These data provide no evidence of association between degree of metabolic control and BMD in adolescents with T1D. Adolescents with T1D have a high prevalence of serum 25-hydroxyvitamin D abnormalities. Longitudinal studies are needed to evaluate the predictive value of vitamin D abnormalities on fracture risk.</p

dodge-research-group/thztools: THzTools v0.3.4 (alpha)

&lt;h3&gt;Changed&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;Fix bug in &lt;code&gt;NoiseModel&lt;/code&gt; example&lt;/li&gt; &lt;li&gt;Replace tuple return value in &lt;code&gt;tdnoisefit&lt;/code&gt; with &lt;code&gt;NoiseResult&lt;/code&gt;&lt;/li&gt; &lt;/ul&gt; &lt;h3&gt;Added&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;&lt;code&gt;NoiseResult&lt;/code&gt; class&lt;/li&gt; &lt;/ul&gt

dodge-research-group/thztools: THzTools v0.3.3 (alpha)

&lt;h3&gt;Changed&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;Prune and update notebooks&lt;/li&gt; &lt;li&gt;Fix error in &lt;code&gt;noiseamp&lt;/code&gt; docstring example (now &lt;code&gt;amplitude&lt;/code&gt; method of &lt;code&gt;NoiseModel&lt;/code&gt; class)&lt;/li&gt; &lt;li&gt;Darken text color for logo in dark mode&lt;/li&gt; &lt;li&gt;Move make-logo script into default hatch environment&lt;/li&gt; &lt;li&gt;Rename sampling time variable from &lt;code&gt;ts&lt;/code&gt; to &lt;code&gt;dt&lt;/code&gt;&lt;/li&gt; &lt;li&gt;Rename &lt;code&gt;thzgen&lt;/code&gt; as &lt;code&gt;wave&lt;/code&gt;&lt;/li&gt; &lt;li&gt;Revise &lt;code&gt;conf.py&lt;/code&gt; in Sphinx documentation&lt;/li&gt; &lt;li&gt;Add SciPy templates for &lt;code&gt;attributes.rst&lt;/code&gt;, &lt;code&gt;class.rst&lt;/code&gt; and &lt;code&gt;method.rst&lt;/code&gt;&lt;/li&gt; &lt;li&gt;Refactor code to decouple computations from sampling time&lt;/li&gt; &lt;li&gt;Make &lt;code&gt;dt&lt;/code&gt; parameter optional in most functions&lt;/li&gt; &lt;li&gt;Set default &lt;code&gt;dt&lt;/code&gt; to &lt;code&gt;None&lt;/code&gt;, to indicate that time units are unspecified&lt;/li&gt; &lt;/ul&gt; &lt;h3&gt;Added&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;&lt;code&gt;NoiseModel&lt;/code&gt; class&lt;/li&gt; &lt;li&gt;&lt;code&gt;transfer_out&lt;/code&gt; function&lt;/li&gt; &lt;li&gt;Example for &lt;code&gt;scaleshift&lt;/code&gt; function&lt;/li&gt; &lt;li&gt;Specify logo based on light/dark theme&lt;/li&gt; &lt;/ul&gt; &lt;h3&gt;Removed&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;&lt;code&gt;noiseamp&lt;/code&gt; and &lt;code&gt;noisevar&lt;/code&gt; functions&lt;/li&gt; &lt;/ul&gt

dodge-research-group/thztools: THzTools v0.3.5 (alpha)

&lt;h3&gt;Added&lt;/h3&gt; &lt;ul&gt; &lt;li&gt;&lt;code&gt;GlobalOptions&lt;/code&gt; class&lt;/li&gt; &lt;li&gt;&lt;code&gt;global_options&lt;/code&gt; module constant&lt;/li&gt; &lt;/ul&gt