Roche-la-Molière – Les roches meulières

Plus communément appelé le site des Rieux, sur le versant sud de cet affleurement rocheux, le site se nomme les Appends/Côte Chez Nous. Il est situé à une altitude comprise entre 490 et 535 m, au nord-ouest de la commune de Roche la Molière. Alain Belmont se déplace en 2009 sur le site des Rieux, montrant une extraction meulière peut-être locale à l’origine de cette exploitation. On y retrouve des meules de 136 cm de diamètre, non décollées du substrat, qui pourraient être contemporaines d’..

Une didactique de la langue, de la culture, et du genre. Le manuel de FLE : discours et réalisations

L’enseignement-apprentissage du Français comme une Langue Etrangère (FLE) se caractérise par l’hétérogénéité de ses situations pédagogiques. Mais ses ressources didactiques comportent aussi des marques de subjectivité qui sont propres à leur contexte de production. C’est pour déceler les marques d’une politique de genre à l’œuvre dans les manuels de FLE que cette recherche a été entreprise. Partant d’une conceptualisation du genre comme un discours non-déclaré (Maurer 2002), didactiquement tr..

Ionization Quenching Factor Measurement of Helium 4

The ionization quenching factor (IQF) is defined as the fraction of energy released by a recoil in a medium through ionization compared with its total kinetic energy. At low energies, in the range of a few keV, the ionization produced in a medium falls rapidly and systematic measurements are needed. We report measurements carried out at such low energies as a function of the pressure in He4 at 350, 700, 1000 and 1300 mbar. In order to produce a nucleus moving with a controlled energy in the detection volume, we have developed an Electron Cyclotron Resonance Ion Source (ECRIS) coupled to an ionization chamber by a differential pumping. The quenching factor of He4 has been measured for the first time down to 1 keV recoil energies. An important deviation with respect to the phenomenological calculations has been found allowing an estimation of the scintillation produced in He4 as a function of pressure. The variation of the IQF as a function of the percentage of isobutane, used as quencher, is also presented

Explanation of the Colour Change in Alexandrites.

Alexandrites are remarkable and rare gemstones. They display an extraordinary colour change according to the ambient lighting, from emerald green in daylight to ruby red in incandescent light from tungsten lamps or candles. While this colour change has been correctly attributed to chromium impurities and their absorption band in the yellow region of the visible light spectrum, no adequate explanation of the mechanism has been given. Here, the alexandrite effect is fully explained by considering the von Kries model of the human colour constancy mechanism. This implies that our colour constancy mechanism is real (objective) and primarily attuned to correct for the colour temperature of black-body illuminants

Muon Flux at the Geographical South Pole

The muon flux at the South-Pole was measured for five zenith angles, $0^{\circ}$, $15^{\circ}$, $35^{\circ}$, $82.13^{\circ}$ and $85.15^{\circ}$ with a scintillator muon telescope incorporating ice Cherenkov tank detectors as the absorber. We compare the measurements with other data and with calculations.Comment: 14 pages, 6 figure

Observing muon decays in water Cherenkov detectors at the Pierre Auger Observatory

Muons decaying in the water volume of a Cherenkov detector of the Pierre Auger Observatory provide a useful calibration point at low energy. Using the digitized waveform continuously recorded by the electronics of each tank, we have devised a simple method to extract the charge spectrum of the Michel electrons, whose typical signal is about 1/8 of a crossing vertical muon. This procedure, moreover, allows continuous monitoring of the detector operation and of its water level. We have checked the procedure with high statistics on a test tank at the Observatory base and applied with success on the whole array.Comment: 4 pages, 2 figures, proceedings of the 29th ICRC Pune, Indi

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics.

Amyloid precursor protein knockout mice (APP-KO) have impaired differentiation of amacrine and horizontal cells. APP is part of a gene family and its paralogue amyloid precursor-like protein 2 (APLP2) has both shared as well as distinct expression patterns to APP, including in the retina. Given the impact of APP in the retina we investigated how APLP2 expression affected the retina using APLP2 knockout mice (APLP2-KO). Using histology, morphometric analysis with noninvasive imaging technique and electron microscopy, we showed that APLP2-KO retina displayed abnormal formation of the outer synaptic layer, accompanied with greatly impaired photoreceptor ribbon synapses in adults. Moreover, APLP2-KO displayed a significant decease in ON-bipolar, rod bipolar and type 2 OFF-cone bipolar cells (36, 21 and 63 %, respectively). Reduction of the number of bipolar cells was accompanied with disrupted dendrites, reduced expression of metabotropic glutamate receptor 6 at the dendritic tips and alteration of axon terminals in the OFF laminae of the inner plexiform layer. In contrast, the APP-KO photoreceptor ribbon synapses and bipolar cells were intact. The APLP2-KO retina displayed numerous phenotypic similarities with the congenital stationary night blindness, a non-progressive retinal degeneration disease characterized by the loss of night vision. The pathological phenotypes in the APLP2-KO mouse correlated to altered transcription of genes involved in pre- and postsynatic structure/function, including CACNA1F, GRM6, TRMP1 and Gα0, and a normal scotopic a-wave electroretinogram amplitude, markedly reduced scotopic electroretinogram b-wave and modestly reduced photopic cone response. This confirmed the impaired function of the photoreceptor ribbon synapses and retinal bipolar cells, as is also observed in congenital stationary night blindness. Since congenital stationary night blindness present at birth, we extended our analysis to retinal differentiation and showed impaired differentiation of different bipolar cell subtypes and an altered temporal sequence of development from OFF to ON laminae in the inner plexiform layer. This was associated with the altered expression patterns of bipolar cell generation and differentiation factors, including MATH3, CHX10, VSX1 and OTX2. These findings demonstrate that APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease

Orally Active Multi-Functional Antioxidants Are Neuroprotective in a Rat Model of Light-Induced Retinal Damage

Progression of age-related macular degeneration has been linked to iron dysregulation and oxidative stress that induce apoptosis of neural retinal cells. Since both antioxidants and chelating agents have been reported to reduce the progression of retinal lesions associated with AMD in experimental animals, the present study evaluates the ability of multi-functional antioxidants containing functional groups that can independently chelate redox metals and quench free radicals to protect the retina against light-induced retinal degeneration, a rat model of dry atrophic AMD.Proof of concept studies were conducted to evaluate the ability of 4-(5-hydroxypyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide (compound 4) and 4-(5-hydroxy-4,6-dimethoxypyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide (compound 8) to reduce retinal damage in 2-week dark adapted Wistar rats exposed to 1000 lx of light for 3 hours. Assessment of the oxidative stress markers 4- hydroxynonenal and nitrotyrosine modified proteins and Thioredoxin by ELISA and Western blots indicated that these compounds reduced the oxidative insult caused by light exposure. The beneficial antioxidant effects of these compounds in providing significant functional and structural protection were confirmed by electroretinography and quantitative histology of the retina.The present study suggests that multi-functional compounds may be effective candidates for preventive therapy of AMD

Calibration of the surface array of the Pierre Auger Observatory

The Pierre Auger Observatory is designed to study cosmic rays of the highest energies (>$10^{19}$eV). The ground array of the Observatory will consist of 1600 water Cherenkov detectors deployed over 3000 km$^2$. The remoteness and large number of detectors require a robust, automatic self-calibration procedure. It relies on the measurement of the average charge collected by a photomultiplier tube from the Cherenkov light produced by a vertical and central through-going muon, determined to 5–10% at the detector via a novel rate-based technique and to 3% precision through analysis of histograms of the charge distribution. The parameters needed for the calibration are measured every minute, allowing for an accurate determination of the signals recorded from extensive air showers produced by primary cosmic rays. The method also enables stable and uniform triggering conditions to be achieved