17 research outputs found
Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particlesâ
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Effect of IL-1beta and TNFalpha inhibition on insulin secretion and metabolic control of type 2 diabetes patients with overweight or obesity
Effect of IL-1beta and TNFalpha inhibition on insulin secretion and metabolic control of type 2 diabetes patients with overweight or obesity
Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus
Laboratorios Silanes, Mexic
Comparison of the use of blood pressure telemonitoring versus standard medical care in the achievement of short-term therapeutic goals in blood pressure in patients with uncontrolled hypertension: An open-label clinical trial
Background In Mexico less than half of the treated hypertensive patients reach blood pressure (BP) targets. Most hypertensive individuals rely on the standard medical care (SMC) to achieve the BP control goals; however, the efficacy of BP telemonitoring (BPT) to achieve BP targets has been poorly studied. Aim To compare the efficacy of BPT versus SMC to achieve BP goals in patients with uncontrolled hypertension. Methods A two-arm, open-label clinical trial was conducted in patients â„18 years with uncontrolled hypertension. The participants were randomized to 2 arms (BPT vs SMC) and followed for 12 weeks. For the statistical analysis, the chi-squared test and covariance were used. Results One hundred and seventy-eight participants were included, BPT (nâ=â94) and SMC (nâ=â84), after 12 weeks of follow up, we observed a baseline-adjusted reduction in systolic BP with both BPT (â13.5 [1.3]â
mmHg) and the SMC (â5.9 [1.4]â
mmHg; pâ<â0.001) but a greater decrease with BPT (pâ<â0.001). Likewise, we found a baseline-adjusted reduction of diastolic BP with BPT (â6.9 [0.9]â
mmHg) and SMC (â2.7 [0.9]â
mmHg) (pâ=â0.007) with a more significant percentage change from baseline with BPT (â6.8% [1.0] vs 2.5% [1.1]; pâ=â0.007). In the BPT arm, a larger proportion of patients achieved the BP target versus SMC (30.5% vs 12.8%; pâ=â0.005). Conclusion BPT showed a greater proportion of patients achieving office BP control goals (<140/90â
mmHg), compared to standard medical care