A influência dos recursos audiovisuais para a aprendizagem autónoma na aula

El rápido avance de las nuevas tecnologías y de las dinámicas económicas ha sembrado una gran incertidumbre sobre a qué retos habrá de enfrentarse la sociedad. Ello incrementa la importancia del aprendizaje autónomo al favorecer la adaptación constante a lo largo de la vida. Debido al auge del consumo de contenidos audiovisuales entre los jóvenes, el empleo de estos contenidos como recursos didácticos en el aula puede ser una herramienta eficaz para comprender conceptos y fomentar su aprendizaje autónomo. Esto potenciará la capacidad de Aprender a aprender del alumnado para conseguir en el futuro una mayor autonomía y adaptación laboral. En este artículo se muestran los resultados más significativos de un cuasi experimento realizado a cuarenta y siete alumnos/as de 3º de eso que buscaba conocer si el uso de recursos audiovisuales en el aula era relevante para su aprendizaje. Uno de los principales objetivos era hallar la utilidad didáctica que pueden tener estos recursos, la cual aumentó de manera significativa, según los datos del cuasi experimento, tras el visionado de un fragmento de la película Tiempos Modernos (Charles Chaplin, 1936). Entre las conclusiones, destaca que puede existir relación entre la percepción de utilidad de los contenidos audiovisuales y el nivel de aprendizaje autónomo del alumnado

scikit-fda: A Python Package for Functional Data Analysis

The library scikit-fda is a Python package for Functional Data Analysis (FDA). It provides a comprehensive set of tools for representation, preprocessing, and exploratory analysis of functional data. The library is built upon and integrated in Python's scientific ecosystem. In particular, it conforms to the scikit-learn application programming interface so as to take advantage of the functionality for machine learning provided by this package: pipelines, model selection, and hyperparameter tuning, among others. The scikit-fda package has been released as free and open-source software under a 3-Clause BSD license and is open to contributions from the FDA community. The library's extensive documentation includes step-by-step tutorials and detailed examples of use

Propuesta de manual BPM, PHS para la empresa Molinera S.A. y manual HACCP para la línea de harina de trigo

Ciclo Optativo de Especialización y Profesionalización en Gestión de Calidad Total y ProductividadEl presente trabajo de titulación se desarrolló en la empresa Molinera S.A., ubicada en el distrito de ATE. El objetivo del trabajo fue elaborar, como propuesta de mejora en calidad e inocuidad, los manuales de las ¨Buenas Prácticas de Manufactura ¨, ¨Plan de Higiene y Saneamiento ¨ y ¨Manual HACCP ¨ para la línea de procesamiento de harina de trigo de la empresa Molinera S.A. Para obtener el diagnostico, primero se realizaron visitas a las instalaciones de la empresa, entrevistando a la gerencia para comunicarles los objetivos del trabajo. En estas visitas coordinadas se evaluó la situación de la empresa a través de entrevistas con los responsables de las distintas áreas de la empresa, obteniéndose información objetiva sobre los procesos, la infraestructura, el personal, la documentación interna y las actividades que se desarrollan en la empresa. Se aplicó una lista de verificación de los requisitos de Higiene en plantas adaptada del D.S Nº 007-98- S.A, Reglamento sobre Vigilancia y Control Sanitario de Alimentos y Bebidas, con la cual la empresa obtuvo un puntaje de 43 puntos de un total de 95 puntos obteniéndose 45.26% de cumplimiento en los requisitos. Con esta puntación la empresa se califica como “REGULAR” en la gestión de los principios generales de higiene de los alimentos. Para definir la propuesta de mejora se usó herramientas de calidad tales como: Tormenta de Ideas, Matriz de Selección y el diagrama de Causa- Efecto; de las cuales se obtuvo como resultado la necesidad de que la empresa cuente con un plan de Higiene y Saneamiento, Manual de Buenas Prácticas de Manufactura y manual HACCP para la línea de producción de harina los cuales son documentos básicos para garantizar que se trabaja en condiciones higiénicas garantizando la inocuidad de los productos que elabora.Tesi

scikit-fda: A python package for functional data análisis

The library scikit-fda is a Python package for functional data analysis (FDA). It pro-vides a comprehensive set of tools for representation, preprocessing, and exploratory analysis of functional data. The library is built upon and integrated in Python’s scientific ecosystem. In particular, it conforms to the scikit-learn application programming inter-face so as to take advantage of the functionality for machine learning provided by this package: Pipelines, model selection, and hyperparameter tuning, among others. The scikit-fda package has been released as free and open-source software under a 3-clause BSD license and is open to contributions from the FDA community. The library’s extensive documentation includes step-by-step tutorials and detailed examples of useThe authors acknowledge financial support from the Spanish Ministry of Education and Innovation, projects PID2019-106827GB-I00 / AEI / 10.13039/501100011033 and PID2019-109387GB-I00. This research was also supported by an FPU grant (Formación de Profesorado Universitario) from the Spanish Ministry of Science, Innovation and Universities(MICIU) with reference FPU18/0004

Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy

OBJECTIVES: To analyze the behavior of the prostate specific antigen velocity (PSAV) in localized prostate adenocarcinoma. MATERIALS AND METHODS: We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups: age, initial PSA value, clinical stage, tumor volume and Gleason score. RESULTS: The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6% and 59.8% when compared with the initial PSA value (p < 0.0001), clinical stage (p = 0.0002), tumor volume (p < 0.0001) and Gleason score (p = 0.0009). CONCLUSION: PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20% and Gleason score lower than 7.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of UrologyUNIFESP, EPM, Division of UrologySciEL

Prognostic value of the percentage of positive fragments in biopsies from patients with localized prostate cancer

OBJECTIVE: To assess the prognostic value of the percentage of positive fragments (PPF) in biopsies from patients with localized prostate cancer (PCa) undergoing radical prostatectomy. MATERIALS AND METHODS: During the period from March 1991 to November 2000, 440 patients were selected. Cases receiving neoadjuvant or adjuvant hormone therapy, or adjuvant radiotherapy, were excluded, as were cases presenting Gleason scores higher than 6 at biopsy. PPF was defined as the total number of fragments divided by the total number of biopsy fragments times 100. This variable was initially divided into categories from 0 to 25%, 25.1% to 50%, 50.1 to 75% and 75% to 100%. During the postoperative period, patients were assessed every 2 months for 1 year, then every 6 months for 5 years, and then yearly. Biochemical recurrence was defined as serum PSA higher than or equal to 0.4 ng/mL. Median follow-up was 60 months. RESULTS: One hundred and nine (24.8%) of the 440 patients under study had biochemical recurrence. In the univariate analysis, PPF significantly influenced disease-free survival (log-rank, p < 0.001), and patients with PPF between 75 and 100% presented a risk of a biochemical recurrence of the disease 3 times higher than patients with PPF between 0 and 25% (p < 0.001). After the Cox regression analysis, both serum PSA (p = 0.001) and PPF (p < 0.001) showed to be independent predictive factors for disease-free survival following surgery. CONCLUSION: PPF measurement in biopsy is a simple and practical method, which should be routinely used as a predictive factor for biochemical recurrence in patients with PCa presenting Gleason scores between 2 and 6.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of UrologyUNIFESP, EPM, Division of UrologySciEL

Prostate Cancer Detection at Rebiopsy After an Initial Benign Diagnosis: Results Using Sextant Extended Prostate Biopsy

INTRODUCTION: Sextant prostate biopsy remains the standard technique for the detection of prostate cancer. It is well known that after a diagnosis of small acinar proliferation (ASAP) or high grade prostate intraepithelial neoplasia (HGPIN), the possibility of finding cancer is approximately 40% and 30%, respectively. OBJECTIVE: We aim to analyze follow-up biopsies on patients who initially received a benign diagnosis after exclusion of HGPIN and ASAP. METHODS: From July 2000 to December 2003, 1177 patients were submitted to sextant extended prostate biopsy in our hospital. The mean patient age was 65.5 years old, and the median number of fragments collected at biopsy was 13. HGPIN and ASAP were excluded from our study. We only considered patients who had a diagnosis of benign at the first biopsy and were subjected to rebiopsies up until May 2005 because of a maintained suspicion of cancer. RESULTS: Cancer was initially detected in 524 patients (44.5%), and the diagnosis was benign in 415 (35.3%). Rebiopsy was indicated for 76 of the latter patients (18.3%) because of a persistent suspicion of cancer. Eight cases of adenocarcinoma (10.5%) were detected, six (75%) at the first rebiopsy. Six patients were submitted to radical prostatectomy, and all tumors were considered clinically significant. CONCLUSION: Our data indicate that in extended prostate biopsy, the first biopsy detects more cancer, and the first, second, and third rebiopsies after an initial benign diagnosis succeed in finding cancer in 7.9% (6/55), 5.9% (1/15) and 20% (1/4) of patients, respectively

Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy

INTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases. In this study, we report on the perspectives for curing prostate cancer in males undergoing radical prostatectomy with Gleason score of 2-6 on prostate biopsy in relation to pre-operative PSA levels. MATERIALS AND METHODS: From 1991 - 2000, we selected 440 individuals whose pathological diagnosis revealed a Gleason score of 2-6 upon prostate biopsy and who subsequently underwent retro-pubic radical prostatectomy due to localized prostate cancer. The clinical stage identified in the group under study was T1c: 206 (46.8%); T2a: 122 (27.7%); T2b: 93 (21.1%); T2c: 17 (3.9%); T3a: 2 (0.5%). Following surgery, we constructed a biochemical recurrence-free survival curve according to pre-operative PSA levels between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, with a median follow-up of 5 years. RESULTS: Following radical prostatectomy, the pathological stage was confirmed as pT2a: 137 (31.1%); T2b: 118 (26.8%); T2c: 85 (19.3%); T3a: 67 (15.2%); T3b: 6 (1.4%); T3c: 22 (5%). The biochemical recurrence-free survival, according to PSA values between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, was 86.6%, 62.7%, 39.8% and 24.8% respectively. CONCLUSION: Better chances for curing low-grade prostate cancer occur in individuals with normal PSA for whom a biopsy is not usually recommended.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of UrologyUNIFESP, EPM, Department of UrologySciEL

Evaluación de la tolerancia a la caliza activa de cinco variedades autorradicadas de almendro

Tradicionalmente, las plantaciones de almendro en secano se han plantado sobre patrones híbridos o francos con marcos amplios, pero en los últimos años se han desarrollado plantaciones en seto utilizando patrones enanizantes como Rootpac-20. Dada la baja adaptación a la sequía de este patrón, se plantea, como un avance en el sistema, conocer la adaptación de variedades autorradicadas o autoenraizadas, que presenten un sistema radicular mejor adaptado a condiciones de sequía, eviten el injerto (con el consiguiente abaratamiento del plantón) y puedan contribuir al aumento de la regularidad de las producciones. En el presente Trabajo Fin de Máster se ha analizado la tolerancia de cinco variedades autorradicadas a diversas concentraciones de caliza activa en suelo, tomando como referencia plantones injertados sobre dos patrones habituales, y realizando un seguimiento del estado fisiológico del material vegetal a lo largo de un ciclo vegetativo. En base a los resultados obtenidos, por sus elevados niveles de clorofila y su tolerancia a la caliza activa, las variedades ‘Guara’ y ‘Penta’ parecen ser las que ofrecen un mayor potencial para mejorar la viabilidad del sistema superintensivo en secano en suelos calizos. No obstante, serán necesarios estudios plurianuales más detallados antes de su implantación en futuras explotaciones.<br /