10 research outputs found
Desarrollo de un sistema Web para la administraci贸n de cuestionarios
n el presenta trabajo, se reportan avances del desarrollo de un sistema Web enfocado a la administraci贸n de cuestionarios con diferentes formatos, es decir, que puedan contener preguntas cerradas, abiertas y/o de opci贸n m煤ltiple, que incluyan texto, im谩genes y video; que soporte un n煤mero ilimitado de usuarios; que sea compatible con cualquier navegador y que adem谩s, pueda ser gratuito para proyectos enfocados a la investigaci贸n
Metodolog铆a de desarrollo evolutivo de escenarios tridimensionales para la creaci贸n de una visita virtual para el Centro Universitario UAEM Ecatepec
Actualmente, uno de los medios de comunicaci贸n claves para acceder al p煤blico en general es el uso de las tecnolog铆as de informaci贸n y comunicaci贸n dentro de las cuales se encuentra la Realidad Virtual, que ha sido utilizada para desarrollar entornos virtuales como una alternativa novedosa de difusi贸n a trav茅s de la Web. Es por ello, que en esta investigaci贸n se propone y se aplica una metodolog铆a para el desarrollo de escenarios tridimensionales para la creaci贸n de una visita virtual: caso Centro Universitario UAEM Ecatepec. Esta metodolog铆a con caracter铆sticas evolutivas permite la eliminaci贸n de errores y alternativas no atractivas al comienzo del proyecto; la entrega de productos intermedios operacionales que se pueden ir refinando en cada iteraci贸n; logrando de esta manera, crear visitas virtuales de una forma organizada en lapsos de tiempo estimado, manteniendo colaboraci贸n y tomando en cuenta los puntos de vista de los integrantes del proyecto, el cliente y/o usuarios
Sistema de realidad virtual inmersivo para el entrenamiento de conductas asertivas
En el presenta trabajo, se reportan avances del desarrollo de un sistema de realidad virtual inmersivo que tiene como finalidad ser una herramienta de ayuda para el entrenamiento en asertividad, enfocado a la resistencia de las presiones socioculturales para cambiar el tama帽o y la forma del cuerpo, las cuales son factores de riesgo en el desarrollo de los trastornos del comportamiento alimentario y el trastorno dism贸rfico corporal
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MAPK13 stabilization via m6A mRNA modification limits anticancer efficacy of rapamycin.
N6-adenosine methylation (m6A) is the most abundant mRNA modification that controls gene expression through diverse mechanisms. Accordingly, m6A-dependent regulation of oncogenes and tumor suppressors contributes to tumor development. However, the role of m6A-mediated gene regulation upon drug treatment or resistance is poorly understood. Here, we report that m6A modification of mitogen-activated protein kinase 13 (MAPK13) mRNA determines the sensitivity of cancer cells to the mechanistic target of rapamycin complex 1 (mTORC1)-targeting agent rapamycin. mTORC1 induces m6A modification of MAPK13 mRNA at its 3 untranslated region through the methyltransferase-like 3 (METTL3)-METTL14-Wilms tumor 1-associating protein(WTAP) methyltransferase complex, facilitating its mRNA degradation via an m6A reader protein YTH domain family protein 2. Rapamycin blunts this process and stabilizes MAPK13. On the other hand, genetic or pharmacological inhibition of MAPK13 enhances rapamycins anticancer effects, which suggests that MAPK13 confers a progrowth signal upon rapamycin treatment, thereby limiting rapamycin efficacy. Together, our data indicate that rapamycin-mediated MAPK13 mRNA stabilization underlies drug resistance, and it should be considered as a promising therapeutic target to sensitize cancer cells to rapamycin
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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines.
A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically modified to include a series of alkoxy-tethered 3,6-substituted 1,2-pyridazines. These derivatives exhibited excellent antiproliferative activity against eight human cancer cell lines from four different cancer types. A 2.5- to 9-fold reduction in IC50 in these cell lines was observed relative to the lead compound, which lacked the appended heterocycle
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Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.
Inspired by the cytotoxicity of perphenazine toward cancer cells and its ability to activate the serine/threonine protein phosphatase 2A (PP2A), we prepared series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, known for its cytotoxicity, nutrient transporter down-regulation and vacuolation properties, incorporating the tricyclic neuroleptics phenoxazine and phenothiazine to represent hybrid structures with possible synergistic cytotoxic activity. While the original activity of the lead compound 3 was diminished by fusion with the phenoxazine or phenothiazine tethered moieties, the corresponding 3-pyridyltetryl ether analog 10 showed cytotoxicity and nutrient transporter down-regulation similar to the lead compound 3, although it separated these PP2A-dependent phenotypes from that of vacuolation